I’ve been on anti-depressants for 11 years since having a stroke and having to stop taking estrogen. I started on Zoloft, then celexa, then Effexor. I’ve been having bad blurry vision for a few years that has my eye dr stumped. Finally my primary doctor thought it could be the Effexor since that is one of the side effects. So we decided that I would wean off the Effexor and try Wellbutrin instead. I lowered the amount of Effexor over 3 weeks till I wasn’t taking it any longer but started the Wellbutrin the last week of taking Effexor. After 3 days of no Effexor the withdrawals seemed to hit me. Headaches, nausea, extremely emotional, and bad dizziness. I had an important event to go to on day 3 of no Effexor so I took a low dose (37.5 mg) hoping to get me through the night. I felt decent for a couple days then boom, the withdrawal symptoms came on fully again. So I decided I would just try to go off both the Effexor and Wellbutrin because I didn’t want to go through this again and really wanted to see if I could handle life without them. Well it’s been a week without any Effexor but the dizziness and emotional outrages are still going on. I’ve been using Bonine (motion sickness) which does seem to help a little. My daughter mentioned the CBD oil which I was totally against at first but after doing a lot of research I am now quite interested in it.

For the past couple of years, the field has been experiencing a boom in cannabidiol-related research. What has permeated the scientific consensus stems from efforts undertaken to explain effects of THC, with descriptions of cannabidiol just a by-product of the initial purpose. For example, CBD was thought to have been simply a precursor of THC, mainly due to the structural similarities between the two.
107. Hindocha C, Freeman TP, Schafer G, et al. Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users. Eur Neuropsychopharmacol. 2015;25:325–334. doi: 10.1016/j.euroneuro.2014.11.014. [PMC free article] [PubMed] [CrossRef]
We tested more than 30 different CBD oil products with our friends and relatives in our search to find the best CBD oil for anxiety. Some of them are pretty good products, some just do almost nothing to manage anxiety or depression. But 7 of them, good products with high potency and effectiveness against depression and anxiety, we included in our top list.
Oxidative stress is responsible for many ailments today. Oxidative stress is when the body has too many free radicals and can’t keep up with neutralizing them (with antioxidants). This is more of a problem now than in the past because our environment is so much more toxic than it once was. A 2010 study shows that CBD oil acts as an antioxidant and another study found CBD has neuroprotective qualities. So CBD can reduce neurological damage caused by free radicals.
We tested more than 30 different CBD oil products with our friends and relatives in our search to find the best CBD oil for anxiety. Some of them are pretty good products, some just do almost nothing to manage anxiety or depression. But 7 of them, good products with high potency and effectiveness against depression and anxiety, we included in our top list.
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011, February 9). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-1226.  http://www.nature.com/npp/journal/v36/n6/full/npp20116a.html?foxtrotcallback=true

27-year-old Bekkii Spain from Sligo in Ireland told Cosmopolitan UK how taking CBD oil made an invaluable difference to her intense anxiety. She began having regular panic attacks back in 2015 due to an uncontrollable fear of her throat closing up. But with counselling being far in the horizon and prescribed medication failing to work for her, Bekkii's anxiety only worsened, and eventually she was admitted to her local psychiatric hospital.


Some manufacturers ship CBD products nationally, an illegal action which the FDA has not enforced in 2018, with CBD remaining as the subject of an FDA investigational new drug evaluation and is not considered legal as a dietary supplement or food ingredient as of November 2018.[70] CBD is openly sold in head shops and health food stores in some states where such sales have not been explicitly legalized.[71][72]

CBD Essence company unquestionably understands some facts about hemp oil. The proprietor Don has genuinely been around the pharmaceutical business for many years, and subsequently, he knows how to convey a quality and successful item. Every one of their oils is made utilizing CO2 extraction techniques. They maintain a strategic distance from CBD isolates, and they generally uncover lab test results to guarantee there is no substantial metals or contaminants in the oil.

i read that hemp derived CBD isnt nearly as “active” or effective as the full spectrum plant based CBD. is this why you’ve introduced the other herbs – to increase the effectiveness of the hemp derived CBD? i also know turmeric has anti-inflammatory properties. so is this the real reason for including this treatment category or does the hemp based CBD have some anti-inflammatory properties also?
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
When Jillian came home for Christmas she and my husband, decided it was time for me to make a decision to do something. I wasn’t ready to decide anything just yet. I wanted to have Christmas with my family. The day after Christmas I made up my mind to drive out to California to investigate cannabis oil as a treatment. We read articles about successful brain tumor results in Spain and Amsterdam and gathered information wherever we could. We decided to give the cannabis oil a try, especially after we read a paper on a study about the chemotherapy my doctor had recommended. That study suggested patients with tumors like mine appeared to get better at first with the chemo but then the left over tumor cells would mutate and turn aggressive over time.
When pain is localized, topical products can be applied. These can be made using CBD-dominant cannabis as well as THC strains. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive. These may be available as CBD oils, ointments, salves, or other forms, and with varying ratios of CBD and THC (a ratio of 1:1 is often recommended as ideal for skin application). The skin has the highest amount and concentration of CB2 receptors in the body.

I’m considering this for my dog, a 50 pound border collie. She has muscle weakness in her back legs likely due to an injury several years ago and now those legs are also spasming at times when she walks. The vet put her on rimadyl (an anti-inflammatory nsaid specifically for dogs) and symptoms improved for several months but are now regressing. We’re guessing inflammation is at the root of it. She’s 13 and we’re willing to take on the risks of CBD although they seem to be low to none but wondering if there would be different considerations for her weight and species. Maybe a half capsule at morning and again at night? Or should we start with a whole one? Thank you!


In recent years, CBD has generated a tremendous amount of interest among consumers, clinicians, and scientists. Why? Not only does evidence suggest CBD counteracts many of THC’s adverse effects, but numerous animal studies and accumulating evidence from human experimental, clinical, and epidemiological studies suggest CBD has powerful anti-anxiety properties. Administered acutely (“as needed”), it appears safe, well-tolerated, and may be beneficial to treat a number of anxiety-related disorders, including:
I have digenerative disc disease/4 bulgin discs was taking 9---10mg hydrocodones a day... i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so... not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again... if im making it seem like a miracle drug... its because it is... so the first week i took 3 drops twice a day... now 3 weeks in... im taking about 5 drops 3 times a day and zero pain pills... for the first time in years i have taken control of my life agin... not depending on doctor scripts/bills etc....

I am having some major issues with major anxiety and major depression that seems to be treatment resistant. I am currently on 75mg of Zoloft, 12.5mg of Seroquel for sleep, 5 to 10 mg of Valium a day and several vitamins as well. I have tried a number of different anti depressants. Nothing seems to be helping much. Out of desperation I have been exploring other options. My question is can I use the oil with all these other meds. Clearly I can’t just stop them but am hoping if I could get the anxiety and depression under control then I could wear off the pharma meds. If you can’t answer this question could you direct me to someone who could. Thanks!!’


I wanted to tell people here that CBD has been very effective for my anxiety, and helps with insomnia. For me, it was a cumulative effect, after a week of one dropper of oil, I can sleep very well at night. I feel like I am not polluting my body with commercial pharmaceuticals. I wish everyone here the best, and hope it works for you as well as it has for me.

My 45 year old son has Type 1 Diabetes and uses insulin. He recently found out that he has a problem with his kidneys. He has had headaches and his sugar and some other blood results are out of therapeutic range. After reading your thorough article, my wife and I want our son to try CBD without THC. We will also try it for other reasons. Where can we get CBD capsules in the 93063 area and how much does it cost? (We are on Social Security). Respectfully, Fred Trombley


Considering the complete non-addictiveness and safety of cannabis, Dr. James Hudson, PhD, Professor Emeritus, University of British Columbia Department of Pathology and Lab Medicine, has said that pharmaceutical companies have an enormous incentive to chemically recreate the natural compounds in marijuana and somehow sell a drug from it. You probably already know this, but pharmaceutical companies can’t patent a natural compound, but if they can make a synthetic compound that mimics ingredient from cannabis, they can formulate that as a drug and potentially make a lot more money off of it.


A survey led by the McGill University Health Centre in Canada revealed that cannabis use results in an improvement in non-cancer pain, sleep, and the mood patterns. In the same survey, it also revealed that ‘high’ and dry mouth were the most commonly reported side effects. People who suffer from cancer also turn to cannabis-related options, including therapeutic grade CBD oil, when the pain of chemotherapy or the disease itself becomes unbearable.

Relevant studies are summarized in Table ​Table3.3. In a SPECT study of resting cerebral blood flow (rCBF) in normal subjects, CBD reduced rCBF in left medial temporal areas, including the amygdala and hippocampus, as well as the hypothalamus and left posterior cingulate gyrus, but increased rCBF in the left parahippocampal gyrus. These rCBF changes were not correlated with anxiolytic effects [102]. In a SPECT study, by the same authors, in patients with SAD, CBD reduced rCBF in overlapping, but distinct, limbic and paralimbic areas; again, with no correlations to anxiolytic effects [104].

© 2018 Floyd's of Leadville. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Cannabinoids are a class of compounds that interact with receptors throughout your body. CBD is just one of dozens of cannabinoids found in cannabis, including tetrahydrocannabinol (THC), which is the one responsible for marijuana’s famous high. Medical cannabis is technically any cannabis product used for medicinal purposes, and these can contain THC or CBD or both, said Nick Jikomes, a neuroscientist at Leafly, a website that provides information about legal cannabis. “A common mistake people make is to think that CBD is ‘the medical cannabinoid’ and THC is ‘the recreational cannabinoid.’” That’s inaccurate, he said, because THC is a potent anti-inflammatory and can be helpful for pain.
Well, apart from day to day anxiety that most of us suffer with, anxiety is actually a very complex disorder, which can be at times extremely paralyzing and debilitating. According to recent data published by the National Institute of Mental Health, Anxiety disorders affect 19.1% of adults in the United States in any given year. Furthermore, it is estimate that 31.1% of American adults experience any anxiety disorder at some time in their lives.
At first, some people who deal with anxiety are apprehensive about CBD oil because it comes from essentially the same plant as marijuana. Marijuana contains THC, which is the psychoactive compound that causes you to get ‘high’ during use, and can lead to increased anxiety or paranoia. CBD oil is nothing like marijuana, and it does not contain THC at all. CBD oil can actually treat some of the adverse effects of THC.
What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.
Another major reason why CBD oil has been positively received in some parts of the medical community is its apparent effect on cancer and tumor growth.A study done by the researchers of the Institute of Toxicology and Pharmacology, University of Rostock, Germany recommends the use of CBD oil (even direct injection into tumors) to eliminate or reduce the size of the tumors. The antioxidants in CBD hemp oil also provide anti-mutagenic properties and lower users’ risk of cancer.
“It is important to remember that CBD benefits and improves the activity in the endocannabinoid system by increasing the time anandamide works on the CB1 and CB2 receptors,” writes Dr. Michael Moskowitz. “Anandamide works on the serotonin, norepinephrine, and dopamine systems. It also works on the GABA-glutamate system and the hypothalamic-pituitary-adrenal axis. Its main role is restoring balance through inhibition when levels are too high and enhancement when they are too low. This is the most likely reason phytocannabinoids in general and CBD specifically are able to regulate depression and anxiety.”[321]
A group of specialists at the National Cancer Institute reviewed some experiments rhesus monkeys and rodents whose results implied that CBD has the capacity to inhibit the division of cancerous cells (especially in types of leukemia and lymphoma), to lower the probability of affected tissue to spread to neighboring tissues, and to increase the effectiveness of macrophage cells to attack cancerous cells.[20][21]
Do not confuse cannabis oil extracts(marijuana) with hemp seed oil, which is the oil expeller pressed from hemp seed and not chemically extracted from cannabis leaves and flowers.  Marijuana oil extracts on the other hand contain from 5-20% THC. WE DO NOT CARRY THIS OIL.  ALL OUR OILS ARE LEGAL IN THE UNITED STATES. All of our Oils come from the Industrial Hemp Plant and are legal in all 50 states. 

Hi Ben, your product sounds amazing! I am 60 years old, have had Neurosarcoidosis for the past 35 years, am a 5 yr colon cancer survivor, and have been recently diagnosed with Pseudotumor Cerebrii (IIH). Between the Neurosarc and the PTC my optic nerves have been greatly affected. My question is about possible drug interactions with your product. Are there any? Specifically, any adverse interactions when the your product is taken in conjunction with Effexor XR, or Toprol XL. Or if one is allergic to Sulfa drugs. Hoping I can take your product and that it will have a positive effect in reducing my “Brain Pain”, optic nerve swelling, and various other neuro symptoms and pain. Thanks.
...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
Cannabinoids affect the transmission of pain signals from the affected region to the brain (ascending) and from the brain to the affected region (descending). A 2011 study showed that CBD and CBC stimulated descending pain-blocking pathways in the nervous system and caused analgesia by interacting with several target proteins involved in nociceptive control. Authors concluded that the cannabinoids “might represent useful therapeutic agents with multiple mechanisms of action.” [387] The following year, researchers reported that CBD significantly suppressed chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance in animals. [388] And then in 2013, researchers concluded that chronic pain patients prescribed hydrocodone were less likely to take the painkiller if they used cannabis. [389]

Agreed with this blog. CBD is best to treat anxiety, depression, pain, chronic pain, inflammation, Alzheimer’s and many more diseases. I’ve experienced good qualities of CBD. I was suffering from the chronic pain for a very long time. One of my friends suggested me to take CBD oil which can treat my pain. I took it for a few weeks twice a day and the pain was totally gone. I felt more relaxed and calm than ever before. I am wondering that how CBD can cure this much effectively? https://cbdreamers.com/cbd-oil-for-anxiety-and-depression I love CBD and I recommend it to people.

Currently available pharmacological treatments include serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors, benzodiazepines, monoamine oxidase inhibitors, tricyclic antidepressant drugs, and partial 5-hydroxytryptamine (5-HT)1A receptor agonists. Anticonvulsants and atypical antipsychotics are also used to treat PTSD. These medications are associated with limited response rates and residual symptoms, particularly in PTSD, and adverse effects may also limit tolerability and adherence [7–10]. The substantial burden of anxiety-related disorders and the limitations of current treatments place a high priority on developing novel pharmaceutical treatments.
I have/had ovarian/primary peritoneal cancer. I used thc/cbd oil pills I self made from the start. I am supposedly their “poster child”. I went thru with chemo and surgery. Oh that horror! But when I tried to tell two seperate doctors, the surgeon was all about it, and my oncologist threw a fit and said it was an anecdote. There are more than 100 studies at the NIH govt website.

Relevant studies in animal models are summarized in chronological order in Table ​Table1.1. CBD has been studied in a wide range of animal models of general anxiety, including the elevated plus maze (EPM), the Vogel-conflict test (VCT), and the elevated T maze (ETM). See Table ​Table11 for the anxiolytic effect specific to each paradigm. Initial studies of CBD in these models showed conflicting results: high (100 mg/kg) doses were ineffective, while low (10 mg/kg) doses were anxiolytic [59, 60]. When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose–response curve, with anxiolytic effects observed at moderate but not higher doses [61, 90]. All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [62, 65], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Campos et al. [66] showed that in rat, CBD treatment for 21 days attenuated inhibitory avoidance acquisition [83]. Long et al. [69] showed that, in mouse, CBD produced moderate anxiolytic effects in some paradigms, with no effects in others.
As mentioned previously, while CBD-dominant products help some people sleep, in others it promotes wakefulness. Orally administered THC, especially products from heavier “Kush” strains and Purple cannabis varieties, are very effective for sleep disorders. These tend to be high in myrcene and linalool, a terpene shared with lavender and known to be effective for relaxation. Cannabis combinations with ratios of 1:1, 4:1, or 24:1 CBD:THC can be used when patients want to reduce psychoactivity.
At the federal level, CBD is classified as a Schedule 1 drug in the U.S. because it is one of the many cannabinoids present in marijuana. To be labeled a schedule 1 drug means that it has a high potential for abuse and the potential to create severe psychological or physical dependence; therefore these drugs are not allowed to be used for medical use.
×