[193] N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet, and I. Bab, “Cannabidiol, A Major Nonpsychotropic Cannabis Constituent, Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts,” Journal of Mineral and Bone Research 30, no. 10 (October 2015): 1905–1913.
NatureCBD has ashwaganda.. In terms of dosage it's ALWAYS recommended to consult healthcare professional before taking any supplements, including NatureCBD; as everybody responds differently to CBD. Depending on your tolerance of the product, 2-4 capsules 30-60 min before bed should be helpful; recommended upper limit per 24-hour period is 5 capsules
Cannabidiol Oil, or CBD as it’s more commonly known, has recently moved to the forefront in the medical cannabis diaspora. It’s a rising star, boasting wide-ranging health benefits.Cannabidiol CBD is one of at least 85 known cannabinoids. These are compounds found in the cannabis plant. Unlike its infamous cousin THC (Tetrahydrocannabinol), however, CBD has no psychoactive properties whatsoever.
Hi Cynthia, we use a Full Plant, Full Spectrum plant based CBD. We absolutely do NOT use an isolate or a synthetic. We add the herbs to create an enhanced experienced beyond that of just CBD. We believe that CBD is part of the solution, and when mixed with other herbs, we can create an experience that goes beyond CBD alone. Nature CBD is a proprietary blend made with unique herbs to create what we think is the perfect experience for our customers.
Considering the complete non-addictiveness and safety of cannabis, Dr. James Hudson, PhD, Professor Emeritus, University of British Columbia Department of Pathology and Lab Medicine, has said that pharmaceutical companies have an enormous incentive to chemically recreate the natural compounds in marijuana and somehow sell a drug from it. You probably already know this, but pharmaceutical companies can’t patent a natural compound, but if they can make a synthetic compound that mimics ingredient from cannabis, they can formulate that as a drug and potentially make a lot more money off of it.
I put two drops in my coffee (yes, I realize mixing hemp oil with caffeine is a bananas thing to do, but I need coffee and it is recommended on the website). The oil is much less unpleasant to take this way, although it does hugely change the taste of your coffee, so perhaps save it for your instant coffee, rather than your $5 slow-roasted French drip latte.
With some of the dreadful reactions I have had to medications I mostly say no to drugs. The psychotropics turn me psycho. I read about addictions and have been through thus…I went off cold turkey with pain medication, antidepressants, anti psychotics, anti anxiety…I do not care to go through anything like that again. If I can get something stronger than an OTC I only want a low dose and do not want to go through what I did in 2010 again. This is where I am currently. Maybe my pain is not as severe as pain is for others. I do know what withdrawal is like and…I have had a good life all in all. I endeavor to be content and learn what I can. I do know what does not work for me.
CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.
2.)  This study shows great potential for using THC as a potentially relievement and we have to admit, the lack of attention as well as the legislative effect it has had really bothers us.  This study was done back in 2006, almost 12 years ago, and it clearly states that surgery and radiology did not improve the patient’s condition, but THC potentially relievement did.  With such a positive conclusion showing these alternatives as potential potentially relievement options for cancer, we are extremely disappointed in the lack of change in the medical community to include more of these options.  View Source
[422] M. H. N. Chagas, A. L. Eckeli, A. W. Zuardi, M. A. Pena-Pereira, M. A. Sobreira-Neto, E. T. Sobreira, M. R. Camilo, M. M. Bergamaschi, C. H. Schenck, J. E. C. Hallak, V. Tumas, and J. A. S. Crippa, “Cannabidiol Can Improve Complex Sleep-Related Behaviours Associated with Rapid Eye Movement Sleep Behaviour Disorder in Parkinson’s Disease Patients: A Case Series,” Journal of Clinical Pharmacy and Therapeutics 39 (2014): 564–566. doi:10.1111/jcpt.12179.
CBD, or cannabidiol, is an extract from cannabis. Helping to reduce anxiety, overactive mind, paranoia, inflammation, and a host of other problems in the body, CBD for insomnia is a great choice. This is due to CBD’s ability to regulate sleep cycles, helping to decrease activity in the brain and lead you to a restful, relaxed state of mind. For those with major insomnia, CBD proves to be a powerful cure — especially if you would prefer not to take prescription drugs or sleep aids.

The immediate and powerful effects of THC are explained because of the special affinity it has with the CB1 type receptors, which mediate crucial processes in the brain. The less prominent (but no less important) action of CBD was explained, at least for a while, by hypothesizing that it binds to CB2 type receptors, hence its more diffuse manner of exercising changes in the body. Early on, the antipsychotic effects of cannabidiol were observed, an aspect which seemed to be in consonance with this initial hypothesis.

The regular followers of this blog would know that I suffer from back pain and sleep disorders. So, before I test out CBD products, I give myself a break from CBD to see how the product affects me fully. Fab CBD sells, 4 versions of the CBD Oil with 150mg, 300mg, 600mg and 1200mg. For people who like flavors with their oils, there are different flavors available too.

Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.

I am in Santiago, Chile and have bought Cannabis oil here. It is my first time to try it. I am awaiting shipment from U.S. of CBD oil products. I am using the oil to ally my rather constant low level anxiety that sometimes goes near panic as well as chronic sleeplessness. I have been dealing with this challenge for many years without resorting to standard “Harmapheuticals”. It is my hope the oils will calm me and bring me sleep. I have been trying these local oils for past four days without too much in the way of calming effects. I am taking around 30ml of the oil without real positive results. Do you suppose I may have to go to dosage over 100ml a day to get results? I realize you can not give medical advice nor am I asking for it–but if you can give me general directions it would be very helpful. Thanks, Jack in Chile.
Intoxicating– Meaning that a substance is habit forming, and can cause you to lose control of yourself. Almost all illegal drugs are considered intoxicating, although at a global scale alcohol is considered to be the most intoxicating of all drugs. Intoxication can take place by directly affecting the brain (psychoactive) or by damaging your body (through toxicity, hence the term).

To access CBD oil, a solvent extraction process is required, which returns roughly 3-5 grams of oil per ounce of flower product used. Using grain or isopropyl alcohol as a solvent, you can strain the result of the mixture, leaving CBD oil behind. It is a lengthy process, and in countries where cannabis is legal, there are many places to access high-quality CBD oil.
With some of the dreadful reactions I have had to medications I mostly say no to drugs. The psychotropics turn me psycho. I read about addictions and have been through thus…I went off cold turkey with pain medication, antidepressants, anti psychotics, anti anxiety…I do not care to go through anything like that again. If I can get something stronger than an OTC I only want a low dose and do not want to go through what I did in 2010 again. This is where I am currently. Maybe my pain is not as severe as pain is for others. I do know what withdrawal is like and…I have had a good life all in all. I endeavor to be content and learn what I can. I do know what does not work for me.
Endoca is a company with a mission. This family-run CBD operation is starting a movement for wellness, sustainability, and community progress, all through the creation of the best-possible CBD products. Endoca grows and harvests their own organic hemp on a sustainable permaculture farm, using self-built equipment, and is developing a self-sufficient village to support its eco-friendly processing and manufacturing plant. The company runs a hemp seed bank, edible plant forestry endeavor, meditation and collaborative wellness center, and charitable foundation to supply CBD to families in need. Endoca brings the same uncompromising ideals to its production of top-quality CBD products, which it oversees “from seed to shelf.”
CBD oil stands for cannabidiol or better known as Hemp oil. Yes, this oil comes from the cannabis plant, therefore the name. Its secret is in the chemicals known as cannabinoids. There are a lot of them and it is known that they have the ability to react with certain brain receptors and other ones located through the body. CBDs popularity has grown in recent years as it offers a calming and soothing effect on users with few or no side effects.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.

When Jillian came home for Christmas she and my husband, decided it was time for me to make a decision to do something. I wasn’t ready to decide anything just yet. I wanted to have Christmas with my family. The day after Christmas I made up my mind to drive out to California to investigate cannabis oil as a treatment. We read articles about successful brain tumor results in Spain and Amsterdam and gathered information wherever we could. We decided to give the cannabis oil a try, especially after we read a paper on a study about the chemotherapy my doctor had recommended. That study suggested patients with tumors like mine appeared to get better at first with the chemo but then the left over tumor cells would mutate and turn aggressive over time.


The skin has the highest amount and concentration of CB2 receptors in the body. When applied topically as an infused lotion, serum, oil, or salve, the antioxidant (a more powerful antioxidant than vitamins E and C)[194] in CBD oil has many benefits and can repair damage from free radicals like UV rays and environmental pollutants. Cannabinoid receptors can be found in the skin and seem to be connected to the regulation of oil production in the sebaceous glands.[195] Cannabis-based topical products are being developed to treat related issues from acne to psoriasis and can promote faster healing of damaged skin. In fact, historical documents show that cannabis preparations have been used for wound healing in both animals and people in a range of cultures spanning the globe and going back thousands of years. The use of concentrated cannabis and CBD oils to benefit and treat skin cancer is gaining popularity with a number of well-documented cases of people curing both melanoma and carcinoma-type skin cancers with the topical application of CBD and THC products. Best known is the case of Rick Simpson, who cured his basal cell carcinoma with cannabis oil and now has a widely distributed line of products. Cannabis applied topically is not psychoactive.

So, what is the best way to use CBD oil? CBD comes in a variety of forms, such as oil, tincture, oil for vaping, sublingual spray, edibles, and topical creams, so you can choose the method that is most suitable for your use. The main idea behind all the methods of using CBD is to make sure that this cannabinoid ends up in your system in an easy manner, producing the results you want. But when it comes to choosing the right method, it depends very much on the optimal dose in your case, the results you wish to achieve, and how long you want its effects to last. So, there isn’t a general rule when it comes to using CBD products.


I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you


Thanks for your interest in our products. Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can though share our top selling products in each category. Please view the links below:http://cbdoilreview.org/product/elixinol-cbd-oil-extract-x-pen-1000mg/http://cbdoilreview.org/product/endoca-hemp-oil-drops-1500mg/http://cbdoilreview.org/product/elixinol-hemp-oil-drops-regular-300mg/http://cbdoilreview.org/product/elixinol-cbd-hemp-oil-capsules-900mg/https://cbdoilreview.org/product/vape-bright-thrive-cbd-vape-cartridge-200mg/As far as dosage goes, I would recommend reading through our page on dosing. I have attached that link below. https://cbdoilreview.org/cbd-cannabidiol/cbd-dosage/Hopefully these help.

Following cloning of the endogenous receptor for THC, namely the CB1R, endogenous CB1R ligands, or “endocannabinoids” (eCBs) were discovered, namely anandamide (AEA) and 2-arachidonoylglycerol (reviewed in [22]). The CB1R is an inhibitory Gi/o protein-coupled receptor that is mainly localized to nerve terminals, and is expressed on both γ-aminobutryic acid-ergic and glutamatergic neurons. eCBs are fatty acid derivatives that are synthesized on demand in response to neuronal depolarization and Ca2+ influx, via cleavage of membrane phospholipids. The primary mechanism by which eCBs regulate synaptic function is retrograde signaling, wherein eCBs produced by depolarization of the postsynaptic neuron activate presynaptic CB1Rs, leading to inhibition of neurotransmitter release [23]. The “eCB system” includes AEA and 2-arachidonoylglycerol; their respective degradative enzymes fatty acid amide hydroxylase (FAAH) and monoacylglycerol lipase; the CB1R and related CB2 receptor (the latter expressed mainly in the periphery); as well as several other receptors activated by eCBs, including the TRPV1 receptor, peroxisome proliferator-activated receptor-γ, and G protein-coupled 55 receptor, which functionally interact with CB1R signaling (reviewed in [21, 24]). Interactions with the TRPV1 receptor, in particular, appear to be critical in regulating the extent to which eCB release leads to inhibition or facilitation of presynaptic neurotransmitter release [25]. The TRPV1 receptor is a postsynaptic cation channel that underlies sensation of noxious heat in the periphery, with capsacin (hot chili) as an exogenous ligand. TRPV1 receptors are also expressed in the brain, including the amygdala, periaqueductal grey, hippocampus, and other areas [26, 27].
CBD likewise communicates with a neurotransmitter called GABA (gamma-aminobutyric corrosive). GABA transfers messages from one brain cell, or neuron, to another; that message usually is “Back off” or “stop pushing.” GABA advises the body when it’s a great opportunity to shut down, and since a huge number of neurons in the cerebrum react to GABA, the impacts include lessening anxiety, quieting the sensory system, assisting with rest, unwinding the muscles.
The eCB system regulates diverse physiological functions, including caloric energy balance and immune function [28]. The eCB system is also integral to regulation of emotional behavior, being essential to forms of synaptic plasticity that determine learning and response to emotionally salient, particularly highly aversive events [29, 30]. Activation of CB1Rs produces anxiolytic effects in various models of unconditioned fear, relevant to multiple anxiety disorder symptom domains (reviewed in [30–33]). Regarding conditioned fear, the effect of CB1R activation is complex: CB1R activation may enhance or reduce fear expression, depending on brain locus and the eCB ligand [34]; however, CB1R activation potently enhances fear extinction [35], and can prevent fear reconsolidation. Genetic manipulations that impede CB1R activation are anxiogenic [35], and individuals with eCB system gene polymorphisms that reduce eCB tone—for example, FAAH gene polymorphisms—exhibit physiological, psychological, and neuroimaging features consistent with impaired fear regulation [36]. Reduction of AEA–CB1R signaling in the amygdala mediates the anxiogenic effects of corticotropin-releasing hormone [37], and CB1R activation is essential to negative feedback of the neuroendocrine stress response, and protects against the adverse effects of chronic stress [38, 39]. Finally, chronic stress impairs eCB signaling in the hippocampus and amygdala, leading to anxiety [40, 41], and people with PTSD show elevated CB1R availability and reduced peripheral AEA, suggestive of reduced eCB tone [42].

The cannabis plant is filled with hundreds of different compounds, several of which have been studied for decades for their therapeutic benefits. The cannabis compounds that have captured the most scientific interest are known as cannabinoids. Cannabinoids are now used in treatment for a broad—and growing—range of conditions and symptoms, from sleep and pain, to anxiety and inflammation, to Parkinson’s disease and cancer.

Right now, there’s a good chance that you don’t really know what you’re getting from any source. Testing and labeling rules vary by state, but many states that allow legal cannabis also require some kind of testing to verify that the THC and CBD levels listed on the label are accurate. However, this testing is controversial, and results can vary widely between labs, Jikomes said. A study published in March found measurable variations in test results, with some labs consistently reporting higher or lower levels of cannabinoids than others. There are no guarantees that the label accurately reflects what’s in the product. For a 2015 study published in JAMA, researchers tested 75 products purchased in San Francisco, Los Angeles and Seattle and found that only 17 percent were accurately labeled. More than half of the products contained significantly lower levels of cannabinoids than the label promised, and some of them contained only negligible amounts of the compounds. “We need to come up with ways to confidently verify the composition of cannabis products and make this information available to consumers,” Jikomes said.

I used a “cbd tincture 250mg”. After about 3 weeks I started passing blood and protein in urine. I stopped and it cleared up. A couple weeks later I decided to try again and within 3 days it happened again. Could this be due to the type of oil I used or might I have the same problem with any oil I try? It was helping my hip pain and crohns. Thanks!
Cannabidiol is a chemical in the Cannabis sativa plant, also known as marijuana. Over 80 chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. While delta-9-tetrahydrocannabinol (THC) is the major active ingredient, cannabidiol makes up about 40% of cannabis extracts and has been studied for many different uses. According to the U.S. Food and Drug Administration (FDA), because cannabidiol has been studied as a new drug, products containing cannabidiol are not defined as dietary supplements. But there are still products labeled as dietary supplements on the market that contain cannabidiol. The amount of cannabidiol contained in these products is not always reported accurately on the product label.

CBD has been in the news before, as a possible treatment for epilepsy. Research is still in its early days. Researchers are testing how much CBD is able to reduce the number of seizures in people with epilepsy, as well as how safe it is. The American Epilepsy Society states that cannabidiol research offers hope for seizure disorders, and that research is currently being conducted to better understand safe use.


"Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia.
The ugly truth is that the US National Institute on Drug Abuse (NIDA), the agency that oversees 85 percent of the world’s research on controlled substances, is on record stating that its institutional policy is to reject any and all medical marijuana research. “As the National Institute on Drug Abuse, our focus is primarily on the negative consequences of marijuana use,” a NIDA spokesperson told The New York Times in 2010. “We generally do not fund research focused on the potential beneficial medical effects of marijuana.”
The first step to finding your correct CBD dosage is getting as much information as you can about the product you’re using. What is the concentration of CBD? Are there third-party lab tests that can confirm that? The CBD industry is still mainly a grassroots therapeutic movement, and as such, largely unregulated. Concentration and purity levels can differ greatly depending on the manufacturing process.  
Inducible nitric oxide synthase (iNOS) – CBD reduced the overexpression of iNOS in response to colitis. iNOS overexpression is well correlated with disease activity with colitis, and inhibitors of iNOS lead to improvement in experimental models of IBD. iNOS results in high-output production of NO, which results in oxidative damage to the intestine via reactive oxygen species (ROS).
The cannabis plant is filled with hundreds of different compounds, several of which have been studied for decades for their therapeutic benefits. The cannabis compounds that have captured the most scientific interest are known as cannabinoids. Cannabinoids are now used in treatment for a broad—and growing—range of conditions and symptoms, from sleep and pain, to anxiety and inflammation, to Parkinson’s disease and cancer.
Hello Ben, I’m from India. My apologies in advance for a long letter. I’ve found you article very informative and humorous also. While there are a few references to India, they are mostly of turmeric. Marijuana and Hemp recorded use in India is more than 6000 years old. You seem to have missed out on it though you do talk of Persia and early Christianity dating back to 2000 years.
The good news is that most of the official research done on CBD oil has shown that there are very few negative side effects from using it. However, CBD is not without some side effects. Most notably, in the clinical studies for epilepsy, sedation was one of the more common side effects. Decreased appetite and diarrhea were also seen in some patients. Depending on what other medicines they are taking, certain patients may need to have periodic blood tests to check on liver function.

Similar to supplements, CBD production and distribution are not regulated by the FDA. That means it’s important to choose wisely in order to know exactly what you’re getting. A new study in the journal Pediatric Neurology Briefs tested 84 CBD products purchased online and found that 21 percent actually contained THC, 43 percent contained more CBD than listed, and 26 percent contained less CBD than listed.


It’s thought that CBD might affect your health by attaching to receptors in the body’s endocannabinoid system—a complex biological system involved in maintaining certain aspects of your health. Emerging research shows that endocannabinoids may play a role in regulating such functions as memory, sleep, and mood, as well as metabolic processes like energy balance.


The list of cannabinoids currently comprises 113 entries, with more and more additions each year. Of these 113, by far the best documented are tetrahydrocannabinol and cannabidiol (in this order), with the two also being the most abundant constituents of the cannabis plant. In a typical chemical isolation process, cannabidiol makes up a little under half of the entire extract.
Why stress happens and how to manage it Stress is essential for survival; the chemicals it triggers help the body prepare to face danger and cope with difficulty. Long-term stress is linked to various health conditions and can cause physical and psychological symptoms. How is it diagnosed, what types of stress are there, and how is it treated or managed? Read now
Hi Ben. What are your thoughts on the differences, if any, between CBD extracted from hemp (legal to buy for anyone in the US) and CBD extracted from medical cannabis? My instinct is that once extracted, they should be identical because we’re talking about a specific molecule (similar to how ascorbic acid extracted from an orange or bell pepper or made in a lab are identical). However, I had some CBD oil from a major retail website that did not do much for my insomnia, even at high doses. Then I tried some CBD oil from my medical marijuana doc that he claimed was pure CBD (meaning no THC, but I am not sure if there are other terpenes) and of higher quality because it was extracted from medical grade cannabis. I was totally skeptical, but ending up feeling it big time – very calming, almost like being high, but without the random racing thoughts that THC gives me. I am wondering if it’s worth it to shell out for my doc’s product (it is super expensive), or if I should just try another version of hemp-based CBD, such as the one you recommend.

I work well under pressure, but being extremely busy at work has almost made me less productive—I'm constantly distracted by email, Slack, and the people around me, to the point where getting my work done becomes difficult. This week, however, I've found it easier to put my blinders on, block out all distractions (especially social distractions) and focus on one task at a time. I think this is partly related to the lessened anxiety—I feel more frazzled and off task when my anxiety is running high. It almost feels like a newfound sense of clarity and calm that enables me to focus.
For this study, 24 people with social anxiety disorder received either 600 milligrams (mg) of CBD or a placebo an hour and a half before performing a simulated public speaking test. Additionally, 12 other people with social anxiety disorder performed the same test without receiving any CBD treatment. Results revealed that pre-treatment with CBD significantly reduced anxiety, cognitive impairment, and discomfort while participants were delivering their speech.
Recently a friend gave my 80 year old father a small bottle of 550 MG CBD Oil to help him with some chemo side effects. My father does not want it so he gave it to me as he knows I have restless legs at night with tiny little muscle spasms like little fireworks going off in both lower legs from the knee down when I lay down to go to sleep at night.
Moreover, simple statistical data has been showing that CBD oil and anxiety is one of the most thoroughly  searched topics on the internet, at least in terms of cannabis-related therapies and medical treatments. Specific searches on “CBD oil anxiety,” in fact, have increased exponentially over the last five years. This is modern proof that natural cannabis therapies are beginning to “see the light” in terms of widespread use, and indeed many countless thousands of individuals are already reaping the benefits of the hemp-based compound.
Green Roads World really customize the oil to assist you in treating your medical conditions. Green Roads World hires a group of doctors, scientific experts and other human services experts to give reasonable and dependable drugs that are exceptionally dosed for every patient. Green Roads has been nominated on various Top 5 CBD records because of their amazing items. They have indeed paved the way toward expelling lipids and fats to make a 99% unadulterated CBD gem.
My daughter is 31. She has been having terrible problems with alcohol for about 6 or 7 years. As time goes on she just gets worse and worse. Of course her drinking means that she ends up in the company of some pretty awful people. Drinkers of course. These men that she finds only seem to make her life so much worse. She then drinks more to get away from her terrible life and so it goes on. We have tried for years to give her as much support as we can. Financially she has depended on us for years now.
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