Hello. I suffer from GAD, Panic Disorder, and mood disorder. For about a year now I have been contemplating on taking my medication. Number one reason I DO NOT want to take my medication is due to the side effects. I have been prescribed Paxil (which I hear a lot of good stuff about it but also bad) I read the side effect and warning side effects that I should be aware of. One of them was that it might make me feel WORSE AND HAVE SUICIDAL THOUGHTS! Now that to be is beyond scary! I already feel like crap And taking a medication that’s suppose to help me can possibly make me feel worse? That to me sounds scary! So I’ve been researching a lot on CBD oil. All the good benefits and how it has helped many suffering from anxiety and depression. Then I come across this blog that talks about how it works just as an SSRI! That’s amazing. I would rather much try something that is organic made from Mother Nature than Some man made medication. Finally, my husband went out bought me the CBD oil capsules to try out first. Those did not settle well in my stomach ,so I tried vaping. Now let me tell you, I think it was the best thing ever. After 20 min I started calming down, I no longer felt hopeless and I actually felt like eating. Today I am on day 3 of vaping the cbd oil. I woke up feeling good. No head ache today, and I feel calm. It has not yet got me to the 100% where I want to be at but it’s better than nothing. I’m hoping this could help me through my hard time and I won’t have to take my medication. The good thing about CBD oil that is non-psychoactive therefore, you will not get high off of this. They take out the THC part (the part that gets you high) leaving you with CBD which gives you all the benefits.
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I am having some major issues with major anxiety and major depression that seems to be treatment resistant. I am currently on 75mg of Zoloft, 12.5mg of Seroquel for sleep, 5 to 10 mg of Valium a day and several vitamins as well. I have tried a number of different anti depressants. Nothing seems to be helping much. Out of desperation I have been exploring other options. My question is can I use the oil with all these other meds. Clearly I can’t just stop them but am hoping if I could get the anxiety and depression under control then I could wear off the pharma meds. If you can’t answer this question could you direct me to someone who could. Thanks!!’

Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.[8] It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.[40]
Disclaimer: We always recommend that you speak with a licensed medical practitioner before modifying, stopping, or starting use of any medications. The statements made on this page have not been evaluated by the U.S. Food and Drug Administration (FDA). They are not intended to diagnose, cure or prevent any disease. If a condition persists, please contact your physician or healthcare provider. The information provided is not a substitute for a face-to-face consultation with a healthcare provider, and should not be construed as medical advice.

CBD dosing experiments have shown that small dosages of CBD has an “Active” effect, which means that it actually helps you stay active and focused. Interestingly, large dosages have the opposite effect: a sedative effect. More research has to show what is the optimal dosage to take for the anti-anxiety and antidepressant effects to be optimal, but it’s something one can also experiment with to find the dosage that suits them best.

I am a former family doctor and naturopathic physician as well as a medical editor and author, working mostly in academic research. In my practice I have always focused on natural medicine and helped my patients of all ages who haven’t responded to traditional treatments. I also have written a significant number of articles in botanical medicine, addiction, drugs. As of now I'm focused on cannabis researches, especially on cannabidiol, its health benefits and how it can improve life of people with severe diseases. You can read my articles here on CBDreamers
Full spectrum CBD does, however, bring with it the sticky issue of THC. The government regulates concentration levels of THC at 0.3 percent, an amount which results in minimal psychoactivity. But THC metabolites are stored in the fat cells of your body, building up over time. If you ever need to take a drug test, this could create an issue for you.
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Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[32] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[12] Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors.[12] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[33] and this action may be involved in its antidepressant,[34][35] anxiolytic,[35][36] and neuroprotective effects.[37][38] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[39] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[8]
I wonder if you’ve every heard of someone who starts using the CBD oil and their anxiety and depression gets worse. This is what I’m experiencing now. I took Prozac for several years, but have been off of it for over 3 years. I was looking for a good alternative (the side effects of Prozac were unbearable). Maybe it’s a dosage issue. I have been using the drops, about 12 drops two times a day. This particular brand is 200 mg per dose (dose is 30-40 drops). I know you can’t give advice, but I just wondered if you have heard of this happening.
Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now

These preliminary findings piqued Blessing's interest. For instance, she points to a 2011 study of a few dozen people, some of whom had social anxiety disorder, who were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo or nothing at all. (The participants didn't know if they'd been given the drug or the placebo.)
The findings imply that cannabidiol can also be a healthy alternative for patients who have got accustomed to powerful painkiller doses. CBD does not have any steroid properties, and it is an anti-inflammatory drug that is less powerful than analgesics based on opioids. But, CBD is much more prescribed because of its non-side-effect causing properties.
Numerous studies have found results that confirm the ability of marijuana to help anxiety and stress. In 2013 an Israeli study demonstrated that treatment with cannabinoids helped to control emotional responses and prevent stress-related responses for those that had experienced a traumatic experience. In 2015 a group of researchers found that cannabis treatments were effective in reducing anxiety in those suffering from PTSD.
I woke up seriously looking forward to my morning CBD oil fix … I mean, tonic. Truth be told, I’m an anxious person. Although I do a lot to try and calm my nerves, sometimes anxiety gets the best of me. But regardless of emotional or physical stress (I’m training for a marathon and running quite a bit!) I experienced this week, I felt a lot more in control after drinking my CBD oil tonics.  After work, I met up with a friend and felt like I could fully focus on our conversation without distractions. Could it be the CBD?

Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011, February 9). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-1226. Retrieved from http://www.nature.com/npp/journal/v36/n6/full/npp20116a.html?foxtrotcallback=true
When pain is localized, topical products can be applied. These can be made using CBD-dominant cannabis as well as THC strains. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive. These may be available as CBD oils, ointments, salves, or other forms, and with varying ratios of CBD and THC (a ratio of 1:1 is often recommended as ideal for skin application). The skin has the highest amount and concentration of CB2 receptors in the body.
Katie Wells, CTNC, MCHC, Founder and CEO of Wellness Mama, has a background in research, journalism, and nutrition. As a mom of six, she turned to research and took health into her own hands to find answers to her health problems. WellnessMama.com is the culmination of her thousands of hours of research and all posts are medically reviewed and verified by the Wellness Mama research team. Katie is also the author of the bestselling books The Wellness Mama Cookbook and The Wellness Mama 5-Step Lifestyle Detox.
Donald Abrams was a member of the committee that reviewed the evidence that went into producing the report, and he said that the studies they reviewed overwhelmingly used pharmaceutically available preparations that contain THC, including dronabinol, nabilone and the whole-plant extract spray nabiximols, which contains equal parts CBD and THC. It’s impossible to know whether the benefits of cannabis can also be obtained from CBD alone, Abrams said, because CBD is just one of 400 chemicals present in the plant. So far, CBD in isolation has been studied in only a handful of randomized, placebo-controlled trials (considered the gold standard of evidence in medical research), and the evidence remains sparse.

It’s not just anxiety. Uncontrolled inflammation is also associated with depression and psychotic disorders. Lately I’ve been thinking about combining cannabinoid with low dose naltrexone an opioid receptor antagonist. My thinking is that since CBD also interacts with opioid receptors, as an allosoteric modulator, that by blocking those receptors we may get some novel interactions that I think may be beneficial for anxiety and other inflammatory related disorders.
A bit of online digging led me to realize that the active ingredient in Charlotte's Web Everyday Plus Hemp Oil, the product I'd been offered to test, was the chemical compound CBD, which stands for Cannabidiol. Unlike THC, the other crucial compound in hemp and marijuana plants, CBD does not produce the psychoactive effects that make you feel "high"; instead, it actually eases anxiety and makes you less likely to freak out.

CBD hemp oil is derived from certain Cannabis varieties known as Hemp. Representing 40% of all Cannabis extracts, it is the second most abundant of 85 chemicals known as Cannabinoids, that are all present in Cannabis plants. Unfortunately, however, the most intoxicating part of Cannabis known as THC, which is responsible for the so-called “high” that brought about its popularity among Marijuana users, is also the most abundant


I have great interest in CBD and appreciate all the information provided, but I have one basic question regarding the nano-particle comparison especially since Bio availability and the ‘potential dangers of crossing the BBB’ by some in a concern. Simply how can you refer to the CBD ad a nano particle when, for reference, a sheet of paper is about 100,000 nanometers thick. A strand of human DNA is 2.5 nanometers in diameter. There are 25,400,000 nanometers in one inch. A human hair is approximately 80,000- 100,000 nanometers wide. This said, anyone who does any basic search (or research) will find that Nanoparticles are particles between 1 and 100 nanometers in size. You can see my concern with your comparison to a human hair (1/100th the width) is not even close; A ‘large’ nano-particle (100nm) would still be 1/800th the width of the most ‘thin’ human hair. Could you please clarify for me? Thank you!
Here’s another interesting fact for you: CBD has really strong anti-oxidant and anti-inflammatory properties, due primarily to its effects on your adenosine receptors and cytochrome P-450 and 2C enzymes. When this was first discovered, the US government insisted that cannabis had no medical benefits, but at the same time, they took out patent 6,630,507, which gave them rights to the antioxidant properties of cannabis (which they ironically still claim don’t exist). Incidentally, that patent was not extended to actual oil or capsule extracts of cannabis, so the good ol’ US gummint missed out on some pretty good business opportunities, if you ask me.
Could cannabidiol help prevent tumors and other cancers before they grow? A 2012 study showed that animals treated with CBD were significantly less likely to develop colon cancer after being induced with carcinogens in a laboratory.[187] Several studies had already shown that THC prevents tumors and reduces them, including one in 1996 on animal models that found that it decreased the incidence of both benign and hepatic adenoma tumors.[188] In 2015, scientists analyzed the medical records of over eighty-four thousand male patients in California and found that those who used cannabis, but not tobacco, had a rate of bladder cancer that was 45 percent below the norm.[189] Topical products can be used to treat and prevent skin cancers. Continuing research is focused on the best ratio of CBD to THC and the most effective dose level in cancer prevention and treatment.
Everything you need to know about CBD oil CBD oil may offer a range of benefits, including reducing pain and inflammation. Evidence shows that the oil does not contain psychoactive properties and so does not have the same effects as marijuana. Here, learn more about CBD oil and its uses, benefits, and risks. We also discuss its legality in the U.S. Read now
According to a growing body of research, CBD may play a role in the growth of new brain cells, a process known as neurogenesis. CBD is also widely recognized as having anti-oxidant and anti-inflammatory abilities, which make CBD a promising therapy for a wide range of conditions, from neurological disorders to autoimmune diseases to chronic pain and depression.
Solution: Extract the CBD oil from a Hemp plant. Law enforcers seem to be unofficially looking the other way or else, all CBD companies and websites would be shut down.  Why are they looking the other way?  Because even though Hemp is of the cannabis plant family, it is more so considered a cousin of the cannabis plant (full article: Is CBD on the Schedule 1 drug list?). Furthermore, people are buying and selling CBD oil online as a “dietary supplement“, which complies with the DSHEA guidelines by the FDA (source.)

Duchess was diagnosed with cancer in her right anal gland. When the cancer was removed it had spread to her left anal gland and was attached to her bowels. She was given 3 months to live. Since then I have had 2 vets check her glands and have had complete physical. She has a clean bill of health. I am so grateful to you. We are going to start on a maintenance program. I tell everyone how she has done. Thanks
Generally, new users start with one drop on the first day, to get an idea of how it affects them. Depending on the results, and what you’re using it for, you might thereafter take a lot more, or stay consistent. For anxiety, pain, and general health, around 2.5mg to 20mg is often recommended. For epilepsy, on the other hand, you might need as much as 200mg to 300mg.
Answering the question “what is CBD oil” would be incomplete without mentioning the many CBD oil benefits. In addition to positively affecting the endocannabinoid system, CBD has been the focus of more than 23,000 published studies about cannabinoids in relation to various medical indications including anxiety, epilepsy, inflammation, cancer and chronic pain to name few. For a more comprehensive look at these and other studies, visit our medical research and education page.
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