A 2007 study with the pharmaceutical 1:1 CBD:THC spray showed good results in helping patients with chronic pain sleep better.[421] REM sleep behavior disorder (RBD) is characterized by the loss of complete muscle relaxation during REM sleep, associated with nightmares and physical activity during dreaming. Four patients in a case series treated with CBD in 2014 had prompt and substantial reduction in the frequency of RBD-related events without side effects. [422]

For relief of immediate symptoms, as in a flare-up of pain, vaporizing or smoking work well. The medication effect is immediate and lasts one to three hours, whereas most ingested products take thirty to sixty minutes before taking effect (faster on an empty stomach) and last six to eight hours. Vaporizers that use a cartridge filled with the CO2 concentrate are highly effective, and these are available in various ratios of CBD to THC. Herbal vaporizers that use the whole plant are also an effective delivery method. Sublingual sprays or tinctures taken as liquid drops also take effect quickly and last longer than inhaled products.
I have had RA for 21 yrs. This is the only product that I actually see, with my own eyes daily, my arthritic nodules shrinking big time. OMGosh, within 18 hours of taking the tendon nodules on my right wrist were GONE! o more need for wrist braces I have needed for years. I have friends that are experiencing great results to for fibromyalsia and chronic back pain!
For individuals suffering from pain and physical ailments, CBD can be one of the best choices for helping you fall asleep. Through several recent studies, CBD has been shown to help alleviate symptoms of PTSD, MS, inflammation, muscular and joint dysfunction, and of course, insomnia. This is because CBD can help to relieve pain, which can prove to be a serious inhibitor of sleep. CBD can be taken as a pill or through inhaling, which is sometimes a more effective way of inducing a restful state. However, pills can act more quickly on the brain than inhalation methods, which is a consideration for those seeking a faster cure for insomnia from CBD.
Several complexities of the eCB system may impact upon the potential of CBD and other CB1R-activating agents to serve as anxiolytic drugs. First, CB1R agonists, including THC and AEA, have a biphasic effect: low doses are anxiolytic, but higher doses are ineffective or anxiogenic, in both preclinical models in and humans (reviewed in [33, 45]). This biphasic profile may stem from the capacity of CB1R agonists to also activate TRPV1 receptors when administered at a high, but not low dose, as demonstrated for AEA [46]. Activation of TRPV1 receptors is predominantly anxiogenic, and thus a critical balance of eCB levels, determining CB1 versus TRPV1 activation, is proposed to govern emotional behavior [27, 47]. CBD acts as a TRPV1 agonist at high concentrations, potentially by interfering with AEA inactivation [48]. In addition to dose-dependent activation of TRPV1 channels, the anxiogenic versus anxiolytic balance of CB1R agonists also depends on dynamic factors, including environmental stressors [33, 49].
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Cannabidiol is a chemical in the Cannabis sativa plant, also known as marijuana. Over 80 chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. While delta-9-tetrahydrocannabinol (THC) is the major active ingredient, cannabidiol makes up about 40% of cannabis extracts and has been studied for many different uses. According to the U.S. Food and Drug Administration (FDA), because cannabidiol has been studied as a new drug, products containing cannabidiol are not defined as dietary supplements. But there are still products labeled as dietary supplements on the market that contain cannabidiol. The amount of cannabidiol contained in these products is not always reported accurately on the product label.
i have seen post and i have seen people going through a lot of things cause of a stigma that one doesn’t pray for but all thanks to little help i got from Dr Moises Nieto Farino who saw me through pains and make me understand that nothing is to impossible for God to do. now she is well and started her life over again at a point of breaking down. i still cant say much but God know that i am so happy I know I can’t make her stop, I have tried. I realize from reading other peoples posts that I really need to get myself some help, I have paid $10,000. of thousands to get her help and to pay for her life and yet, here I am, depressed and so stressed about something that I am failing to fix. As a mother that is so painful. Alcohol addiction is a terrible thing. It robs people of their lives really. It often feels to me that I am watching her, very slowly, killing herself. Taking me with her too. After I finish writing this I am going to book my self an appointment with a good therapist and try to find perhaps an AA meeting. I have to do something . ThanK YOU Dr Moises Nieto Farino. FOR ALL OF YOUR HELP AND ASISTANNCE TO HELP HER REGAIN ALL SHE LEFT BEHIND. YOU COULD CONTACT Dr Moises Nieto Farino FOR SOME PERSONAL COUNSELING OR FAMILY COUSELING.(CONTACT INFO…moisesfarino112@gmail.com
He calculated the dosage for us to buy i think the dosage he calculated was 60grams of the oil which we ordered plus 30grams maintenance free and also with a body lotion and soap. He told us that if we order it online now by the next 48hours the medication will get to our door step through the delivery services, we decided to give it a try and behold when we did exactly 48hours of ordering the medication came to our door step through the delivery agent and deliver it to us. immediately we emailed Rick back that we have gotten the medication, and the usage instruction manual was also delivered to us. my friend Rose started the medication immediately just after a month of using Rick Simpson cannabis oil, Rose is now free from cancer problem, she is living a healthy life my utmost priority of sharing this short testimony is for those that are suffering from my kind of cancer diseases or if your friend or family members are suffering from this deadly disease, please don’t die in silence there is a cure for your cancer today don’t waste anytime further you have to email Rick Simpson directly and save your live and the lives of others
Studies in humans, including many of those cited below, have demonstrated that CBD dosage reduces anxiety (once again, compared to the increased levels of anxiety that THC produces), and that when you combine CBD with THC, it takes the anxiety edge off THC. This is due to the action of CBD on 5HT1A and TRPV1 receptors, both of which are involved in mitigating the anxiolytic, panic and fear responses to stress.
2.)   Another great conclusion concerning the benefits of CBD hemp oil and Alzheimer’s, “In conclusion, we have found that prepotentially relievement with CBD prevented the expression of proteins potentially involved in tau phosphorylation and Aβ production in GMSCs. Therefore, we suggested that GMSCs preconditioned with CBD possess a molecular profile that might be more beneficial for the potentially relievement of AD.”

Naturally, the testimonies of these experts were based on a comprehensive literature review, an endeavor which we have also undertaken, albeit in a less official capacity. While many new products have been hailed as a panacea in their times, and many web sources certainly allude to this status for CBD, our objective was more modest – presenting ten possible benefits of cannabidiol where sufficient evidence exists to back up the claims.


My 45 year old son has Type 1 Diabetes and uses insulin. He recently found out that he has a problem with his kidneys. He has had headaches and his sugar and some other blood results are out of therapeutic range. After reading your thorough article, my wife and I want our son to try CBD without THC. We will also try it for other reasons. Where can we get CBD capsules in the 93063 area and how much does it cost? (We are on Social Security). Respectfully, Fred Trombley
Full spectrum CBD does, however, bring with it the sticky issue of THC. The government regulates concentration levels of THC at 0.3 percent, an amount which results in minimal psychoactivity. But THC metabolites are stored in the fat cells of your body, building up over time. If you ever need to take a drug test, this could create an issue for you.

The Journal of Autism and Developmental Disorders have found that the mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in children with altered immune responses linked to autism. The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in these children, which led them to conclude that “ data indicates CB2 receptor as a potential therapeutic target for the pharmacological management of the autism care.”  View Source

CBD shows promise in the treatment of anxiety disorders, according to a report published in the journal Neurotherapeutics in 2015. Looking at results from experimental research, clinical trials, and epidemiological studies, the report’s authors found evidence that CBD may help treat generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. However, the authors caution that human-based research on CBD and anxiety is fairly limited at this point.

Hemp Oil is also from the Cannabis Sativa plant but only the seed is cold-pressed to obtain the oil. It is also called Hemp Seed Oil.  It is not tested for CBD content but most likely contains a small amount as it is from the Cannabis Sativa Plant.  Hemp Oil is regulated in its production and is tested for THC amounts but is not tested for CBD amounts.  
This turn is due to a comprehensive 2015 study aimed at two notoriously difficult manifestations of epilepsy – Dravet syndrome and Lennox-Gastaut syndrome – most often encountered in children. Seizure frequency was found to decrease between 54 percent and 67 percent for the six months cannabidiol medication was used, although a small part of individuals did not continue after three months, as their condition did not improve.
CBD Drip makes CBD easy to afford, purchase and use. Their line can be found in many health food shops and retail stores, as well as online, are reasonably priced, and are user-friendly. Their source hemp is pesticide-free, European-grown, and non-GMO, and their broad-spectrum extraction process preserves a wide range of the plants’ cannabinoids, terpenes, antioxidants, and “good fats.” Not only are their products tested by an independent lab for purity, but CBD Drip makes the results of each batch’s third-party tests public on its website, so users can verify their products’ safety for themselves. One of the best ways to use CBD for anxiety in the brand’s product range is with EcoDrops, a line of terpene blends designed to be taken sublingually, and tailored to provide specific effects. There’s Focus, Boost and Relief, but for anxiety, we like Dream, which combines 1,500 mg of active CBD with soothing Lavender, Roman Chamomile and Valerian. This is a great blend for treating insomnia, but can be used for general calming as well. Another option is the company’s unflavored CBD oil, which can be used sublingually or vaped, and comes in strengths of 14.5 mg, 58 mg, 140 mg, 500 mg or 750 mg. Still another choice is CBD Drip’s CBD capsules, which are both vegan and gluten-free. Each potent capsule each contains 30 mg of multi- cannabinoid, full-spectrum hemp extract.
Cannabinoid therapy is connected to the part of the biological matrix where body and brain meet. Since CBD (cannabidiol) and other compounds in cannabis are so similar to the chemicals created by our own bodies, they are integrated better than many synthetic drugs. According to Bradley E. Alger, a leading scientist in the study of endocannabinoids with a PhD from Harvard in experimental psychology, “With complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease.”[175]
If you have a nervous or misbehaving pet, you may be at a loss when it comes to how to help them. Anxiety in dogs can be extremely hard to treat — after all, it’s not like you can have a conversation with your dog to find out what is wrong or how you might be able to help. However, you may have seen CBD making headlines as of late. What is CBD used for when it comes to pets? The answer may surprise you!
CBD Vape Oil is very popular and can be used with a suitable vaporizer. Since this oil is generally viscous, it needs a device that can work with it. Therefore, it cannot be used with all vaporizers. Make sure you have a suitable vaporizer before using a CBD vape oil. CBD Vape oils have different concentrations and flavors. Adding terpenes also contributes to the effect.

Okay, you're about to hear a lot of science GCSE-type words like 'compound' here, but stick with me. CBD stands for cannabidiol, which is a compound (essentially, a natural ingredient) found in the hemp plant. Hemp is part of the same family of plants as cannabis, known as the cannabis sativa family, meaning hemp and cannabis contain many of the same compounds. CBD also exists in cannabis (otherwise known as marijuana), hence the link between the health product and the recreational drug, but you'll find out below why hemp is the plant used to make CBD oil, and not cannabis.
More recent experiments, involving the administration of a part CBD part THC solution, have yielded results that contradict the first supposition. At present, on the evidence that cannabidiol reduces some of the psychoactive effects of tetrahydrocannabinol (acting as a de facto antidepressant), scientists argue that cannabidiol has a holistic but indirect influence on all cannabinoid receptors in the endocannabinoid system. The main consequence of this impact seems to be an increase in the production of endocannabinoids. This is now the prevailing idea that accounts for the mountains of empirical evidence of how the benefits of cannabidiol are expressed at the cellular level.
74. Deiana S, Watanabe A, Yamasaki Y. Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Delta(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour. Psychopharmacology (Berl) 2012;219:859–873. doi: 10.1007/s00213-011-2415-0. [PubMed] [CrossRef]
What do you think about CBD? Why offer those alternatives (which are good for everything, it is patently true not just “provable”, while it is probable). I have chronic pain and scoliosis as well as stiffness and fatigue from schizophrenia medication, and CBD is both antipsychotic and minimizes anxiety, as well as assists pain which allows me TO meditate or exercise. I can’t even do those half as effectively without medical marijuana products. Whatever they are proven to do, pot and pot components are thankfully getting proven and studied more rigorously and informatively.
During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.
Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports. Little research has focused on the safety and side effects of CBD in humans; however, clinical trials indicate that only a few, generally mild side effects have been observed after CBD administration and tolerance for CBD does not seem to occur.

While normally I'd be slightly tripped up by little things like an overly crowded subway car or a full inbox at work, the CBD oil seems to have taken the edge off of my anxiety a bit. Rather than overthinking a sternly worded email or analyzing a social interaction, I've found it easier to recognize the irrationality of these thoughts and actually let them go (instead of ruminating on the situation). In some ways, I feel more like myself. With that said, I've still experienced some social anxiety when meeting new groups of people—I'd be interested to see what taking the full recommended dose would do.
A survey led by the McGill University Health Centre in Canada revealed that cannabis use results in an improvement in non-cancer pain, sleep, and the mood patterns. In the same survey, it also revealed that ‘high’ and dry mouth were the most commonly reported side effects. People who suffer from cancer also turn to cannabis-related options, including therapeutic grade CBD oil, when the pain of chemotherapy or the disease itself becomes unbearable.
Leonard Leinow has three decades of experience growing and studying medical cannabis and brings a unique spiritual perspective to his work. In 2009, he formed Synergy Wellness, a not-for-profit medical cannabis collective in California. Synergy Wellness has over 3,500 members in its collective and is an artisan organization making hand-crafted organic and natural whole plant-based products. They are specialists in CBD (cannabidiol), the non-psychoactive portion of cannabis, and are pioneers in this aspect of the industry. Leinow is known for his proprietary blends of tinctures and medicine used for cancer and epilepsy patients.
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