I found your article to be very informative. My son has refractory Epilepsy and Type 1 Diabetes. I am very interested in CBD but I am concerned about how it will interact with the 3 AED’s he is currently taking as well as how it will affect his blood glucose levels as he is on an insulin pump. Do you know of anyone with a similar combination of issues? How they have handled introducing CBD to their regime? And if they are seeing positive results?
^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
“THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”
A healthy appetite is vital to a healthy body, especially when the body is healing. Some illnesses decrease the appetite to the point of preventing the body from healing itself. CBD stimulates appetite, according to the National Cancer Institute. In the human body, CBDs bind to cannabinoid receptors in the body. Scientists believe these receptors play an important role in regulating feeding behavior. CBDs stimulate appetite when they dock onto these receptors.
Social media is blasting this one out lately, showing that different parents have been treating their children illegally (in states that are not classed as medical states) to help prevent their children from having seizures or deal with epilepsy. While there has been limited scientific evidence on the topic, 2016 was a major turning point for the plant as a major study was conducted by Orrin Devinsky, a neurologist at New York University Langone Medical Center, showing profound results.

During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.


And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
In one of the most complete human clinical trials to date, researchers studied the effects of a standardized extract of ashwagandha on the negative effects of stress, including elevated levels of the stress hormone cortisol. The results were impressive, with participants showing increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being…
In August, eight months after beginning the cannabis treatment, my MRI was reviewed by a leading Radiologist, my Neuro Oncologist, and my world renowned Brain Surgeon, and it was concluded that all that was remaining of the tumor regrowth was scar tissue. I will have another MRI in December. Because these tumors are chronic and tend to growback, I will always be living MRI to MRI, but the key word here is that I am living …and in great health with a great immune system.
As you may know or as you may have forgotten (ha!) short term memory problems are really common with THC. That’s why the extremely funny, laugh-snorting joke you told last night is impossible to remember the next morning. Don’t worry, it probably wasn’t as funny as you thought it was last night. But a 2010 study found that CBD eliminates any memory loss problem from weed. In the study, researchers used plants bred for high CBD and low THC plants, and attributed this attenuation of memory loss to CBD’s role as a CB1 antagonist.
I have digenerative disc disease/4 bulgin discs was taking 9---10mg hydrocodones a day... i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so... not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again... if im making it seem like a miracle drug... its because it is... so the first week i took 3 drops twice a day... now 3 weeks in... im taking about 5 drops 3 times a day and zero pain pills... for the first time in years i have taken control of my life agin... not depending on doctor scripts/bills etc....
de Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrión, O., Crippa, J. A., . . . Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: A chemical compound of cannabis sativa [Abstract]. CNS & Neurological Disorders - Drug Targets, 13(6), 953-960. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24923339

People suffering from other neurological disorders might also benefit from using CBD oil as part of their treatment. Several studies involving Parkinson’s disease showed that participants slept better after treatment. Furthermore, their overall quality of life increased. Amazingly, CBD also showed positive benefits in treating or preventing Alzheimer’s disease. As CBD lowers inflammation, it helps prevent nerves from degenerating. During one study, scientists used mice with the genetic predisposition for Alzheimer’s disease. They found that CBD helped by preventing the mice’s cognitive decline.


Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. We at Plus CBD Oil™ are proud of our innovative selection of products.


Similar to supplements, CBD production and distribution are not regulated by the FDA. That means it’s important to choose wisely in order to know exactly what you’re getting. A new study in the journal Pediatric Neurology Briefs tested 84 CBD products purchased online and found that 21 percent actually contained THC, 43 percent contained more CBD than listed, and 26 percent contained less CBD than listed.
If you have dealt with anxiety before, you are not alone. As the author of a 2015 article published in the Dialogues in Clinical Neuroscience says: "Anxiety disorders...are the most prevalent mental disorders and are associated with immense health care costs and a high burden of disease." Yet many are finding that pharmaceuticals won't do, especially for chronic use, and they are turning increasingly to supplements and cannabidiol (CBD) oil for anxiety. [1]
I have had several neurological conditions like Bells Palsy three times, double vision, paralysis of left side of tongue. I have a lot of relief whenever I have pain by taking an inflamattory drug etoshine90 mg. Presently I have started taking Steroids for my facial palsy. The various pains I was having on the left side of neck, below the left ear, dizziness, pain around the head have subsided immidiately after the first dose of prendisolone 60 mg.I have read that CBD hemp oil can be useful for my condition of neurological and inflammation issues. My question is what concentrate (mg) of the oil should I take and for how long. Any brand that you may suggest that are available in the UK. Thank you.
Most people do not associate cognitive health issues like anxiety, depression, brain fog, ADD, ADHD, and autism with inflammation, but it turns out that is exactly what the research is finding. There is actually a whole field of research known as the cytokine model of cognitive function studying how inflammation messes with our brains and may cause anxiety disorders. One finding is that elevated levels of NF kappa B (NFkB), an inflammatory bad guy, is associated with anxiety while people with lower levels of NFkB often have lower rates of anxiety.
When I first learned about CBD oil, I'll admit I was a bit skeptical. My mind immediately turned to weed and the unnerving experiences I'd had with heightened anxiety in college. For me, a person who's already predisposed to overthinking, marijuana, no matter what the form, would typically put my mind into overdrive and result in a common yet dreaded side effect: paranoia.
CBD (Cannabidiol) is a potent, non-psychoactive cannabinoid found in hemp oil. It is typically extracted from industrial hemp plants that are naturally high in CBD and other phytochemicals. It is the most prevalent of over 80 different cannabinoids found in natural hemp. It is commonly used for its therapeutic properties. Cannabidiol is responsible for a wide-range of positive health benefits through its interaction with the body's own endocannabinoid system.
An animal study using mice found repeated administration of CBD may help the hippocampus regenerate neurons, which could be useful for treating anxiety or depression. Research shows both SSRIs and CBD may promote neurogenesis. This is significant, because evidence suggests that severely impaired neuronal plasticity may influence suicidal behavior. Future research comparing CBD and SSRIs effect on neurogenesis could open up promising new avenues in how we understand depression and how to most effectively treat it.
I will be traveling soon (Vegas), and typically have an extremely hard time falling asleep, if I fall asleep at all, while traveling. In the past I have gone 3 days without sleep only to have to rely on ambien (seems to be the only thing that will knock me out). While at home it takes me a while to fall asleep but it’s not impossible. You mention you take 2-3 capsules to help you sleep, will this be sufficient enough to knock me out or would that require a higher dose? Or would a different product entirely, such as one with more THC be more effective? I recently came across an article on PubMed (not sure if it was mentioned above) that stated that CBD usually has the opposite effect on aiding sleep and that THC is better for sleep. However, you did mention higher dose CBD will not have the opposite effect. So I’m a bit confused.
CBD and THC are the two main compounds in the marijuana plant and they are the only two cannabinoids that have been well characterized to date. Many strains of marijuana are known for having abundant levels of THC and high-CBD strains are less common; however, with the medical community paying more attention to the therapeutic effects of CBD, that is beginning to change.
Cannabidiol Oil, or CBD as it’s more commonly known, has recently moved to the forefront in the medical cannabis diaspora. It’s a rising star, boasting wide-ranging health benefits.Cannabidiol CBD is one of at least 85 known cannabinoids. These are compounds found in the cannabis plant. Unlike its infamous cousin THC (Tetrahydrocannabinol), however, CBD has no psychoactive properties whatsoever.

Oral consumption is recommended as it usually lasts the whole night. Always start with the micro dose to test sensitivity and go up as needed within the dosing range before going to the next, until symptoms subside. The micro to standard dose is usually recommended to treat insomnia and sleep apnea. When relaxing indica strains are used with higher THC levels, a dose of 5–10 mg is usually sufficient. Other people find they need larger doses, such as 15–40 mg. CBD taken as a tincture or edible will aid in a restful six to seven hours of sleep. This type of disorder varies widely from one patient to the next. Often, one needs to perform some experimental research and try strains of different CBD:THC ratios to figure out how CBD oil benefits their sleep and the best protocol.
CBD Vape Oil is very popular and can be used with a suitable vaporizer. Since this oil is generally viscous, it needs a device that can work with it. Therefore, it cannot be used with all vaporizers. Make sure you have a suitable vaporizer before using a CBD vape oil. CBD Vape oils have different concentrations and flavors. Adding terpenes also contributes to the effect.
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.[8] It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.[40]
So there: now I’m a bonified druggie. But let’s move on, because in this article, we’re going to delve into a derivative of the cannabis plant family that has some pretty massive payoffs for balancing your endocrine system, relieving anxiety, modulating chronic stress, shutting down inflammation and chronic pain, decreasing blood sugar, decreasing appetite and lowering abdominal obesity.
CBD oil’s role in cancer treatment still needs more research, but what is available is looking promising. According to the American Cancer Society, CBD oil can slow growth and spread of some kinds of cancer (in animals). Because it fights oxidative stress and inflammation (and both are linked to cancer) it makes sense that CBD oil could help fight cancer cells.
Low Blood Pressure and Lightheadedness – an effect of CBD that may seem somewhat counterintuitive, an almost immediate (though small) decrease in blood pressure has been reported at the exposure to high doses, causing the associated lightheadedness, albeit not for long periods. Nevertheless, it could be significant for individuals taking blood pressure medication.
"A CBD company may create a CBD oil, test it, and use the test results to create their label," Bonn-Miller says. "The problem is if they never test their product again, or they test it once a year, you have no idea whether each batch is the same as the first one that they used to create the label. The vast majority of companies are not using manufacturing standards that assure product consistency over time. Companies should be testing every batch they make and tossing batches that don't fall within the specs of their label."
Hi Lauren I've just started today with 250mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well. Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve. Thank you Lyn
At the federal level, CBD is classified as a Schedule 1 drug in the U.S. because it is one of the many cannabinoids present in marijuana. To be labeled a schedule 1 drug means that it has a high potential for abuse and the potential to create severe psychological or physical dependence; therefore these drugs are not allowed to be used for medical use.
Various strains of "medical marijuana" are found to have a significant variation in the ratios of CBD-to-THC, and are known to contain other non-psychotropic cannabinoids.[60] Any psychoactive marijuana, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. Non-psychoactive hemp (also commonly-termed industrial hemp), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆-9 tetrahydrocannabinol concentration of no more than three-tenths of one percent (0.3%) on a dry weight basis.[61] Certain standards are required for legal growing, cultivating and producing the hemp plant. The Colorado Industrial Hemp Program registers growers of industrial hemp and samples crops to verify that the THC concentration does not exceed 0.3% on a dry weight basis.[61]
It’s also nearly impossible to overdose on CBD. Kind of like water, dark chocolate, and steamed kale, it has an unusually low level of toxicity. In the last 6,000 years, CBD hasn’t killed anyone via overdose, which is particularly impressive when you compare it to non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, Advil and Tylenol, which can wreak havoc on your gut lining, liver and kidneys. Or aspirin (salicylic acid) which kills over 1,000 people every year. Or alcohol, which kills over 110,000 people a year. No one’s ever died from CBD.
I woke up seriously looking forward to my morning CBD oil fix … I mean, tonic. Truth be told, I’m an anxious person. Although I do a lot to try and calm my nerves, sometimes anxiety gets the best of me. But regardless of emotional or physical stress (I’m training for a marathon and running quite a bit!) I experienced this week, I felt a lot more in control after drinking my CBD oil tonics.  After work, I met up with a friend and felt like I could fully focus on our conversation without distractions. Could it be the CBD?
Its sad to know the history behind the weed, I hope the government stop sabotage the good things in order to profit, and this product could be more affordable to all people like paracetamol is. Stop hiding the true and making us puppets..how many will die from diseases and manipulation until they change? Is sad to know the true but makes me happy to know people like you, Helping people to awake and be cured by this cruel world ..
In a double-blind, placebo-controlled study, 24 smokers were randomly chosen to receive either an inhaler of CBD oil or a placebo. Participants were asked to take a puff every time they had an urge to puff a cigarette. Over the week, those with placebo inhalers saw no change in their total number of cigarettes consumed, while those who were taking CBD saw a nearly 40 percent drop in their intake. Using the inhaler decreased the number of cigarettes without increasing their craving for nicotine, pointing towards a purpose for Cannabidiol in the withdrawal process.
Cannabinoids are neuroprotective, meaning that they help maintain and regulate brain health. The effects appear to be related to several actions they have on the brain, including the removal of damaged cells and the improved efficiency of mitochondria.[190] CBD and other antioxidant compounds in cannabis also work to reduce glutamate toxicity. Extra glutamate, which stimulates nerve cells in the brain to fire, causes cells to become over-stimulated, ultimately leading to cell damage or death. Thus, cannabinoids help protect brain cells from damage, keeping the organ healthy and functioning properly. CBD has also been shown to have an anti-inflammatory effect on the brain.[191]
CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.
A: Our Hemp Oil is regulated to contain no levels of THC as per the legal limits of the State of Idaho. Our Premium Hemp Oil is also tested and contains no levels of THC. Our Hemp Oil and Premium Hemp Oil are both 100% from the Cannabis plant (save the Peppermint Essential Oil Flavoring and Stevia in our Peppermint option). We do not dilute or use any fillers such as Medium Chain Triglycerides (MCT), Vegetable Glycerin, or other fillers.  
I am a former family doctor and naturopathic physician as well as a medical editor and author, working mostly in academic research. In my practice I have always focused on natural medicine and helped my patients of all ages who haven’t responded to traditional treatments. I also have written a significant number of articles in botanical medicine, addiction, drugs. As of now I'm focused on cannabis researches, especially on cannabidiol, its health benefits and how it can improve life of people with severe diseases. You can read my articles here on CBDreamers
I will be traveling soon (Vegas), and typically have an extremely hard time falling asleep, if I fall asleep at all, while traveling. In the past I have gone 3 days without sleep only to have to rely on ambien (seems to be the only thing that will knock me out). While at home it takes me a while to fall asleep but it’s not impossible. You mention you take 2-3 capsules to help you sleep, will this be sufficient enough to knock me out or would that require a higher dose? Or would a different product entirely, such as one with more THC be more effective? I recently came across an article on PubMed (not sure if it was mentioned above) that stated that CBD usually has the opposite effect on aiding sleep and that THC is better for sleep. However, you did mention higher dose CBD will not have the opposite effect. So I’m a bit confused.

Dr. Robert Carson is a pediatric neurologist at Vanderbilt University who has evaluated the effectiveness of CBD supplements in kids with seizures. He says the supplements can be beneficial for these children. However, he says, if the FDA follows its advisory panel's advice and approves a pharmaceutical-grade CBD drug, that would open up a new treatment option by delivering a high-quality, consistent dose of CBD.


Thirty minutes later, I was surprised by how subtle the effect was. While I expected a hazy nodding-off effect similar to melatonin's, the oil simply relaxed my body ever so slightly—my heart stopped pounding against my chest, my legs stopped kicking beneath my sheets, my mind stopped racing. I wasn't sure if it was the oil or the late hour, but eventually, physical relaxation gave way to mental relaxation, and I drifted off to sleep.
An animal study using mice found repeated administration of CBD may help the hippocampus regenerate neurons, which could be useful for treating anxiety or depression. Research shows both SSRIs and CBD may promote neurogenesis. This is significant, because evidence suggests that severely impaired neuronal plasticity may influence suicidal behavior. Future research comparing CBD and SSRIs effect on neurogenesis could open up promising new avenues in how we understand depression and how to most effectively treat it.
CBDPure is one of the only companies that stands by its product. With countless fly-by-night CBD oil scam companies popping up, it’s reassuring to know that if for any reason you don’t like CBDPure’s oil, you’re eligible for a full refund. We don’t think you’ll need it, though: after interviewing patients, reading accounts of anxiety sufferers and their experience with CBDPure, and our own experience with the company, we can confidently say that no other product comes close to providing anxiety relief than CBDPure’s Hemp Oil 600.
If CBD-dominant products alone are not enough to treat a particular case, products with a higher ratio of THC are sometimes recommended to better manage pain. For day use, more stimulating, sativa varieties with higher concentrations of myrcene could be added to the formula. In general, for pain, and especially for evening and nighttime, indica strains are favored for their relaxing, sedative effect. A person without experience with THC should use caution and titrate slowly up to higher doses. Research as well as patient feedback have indicated that, in general, a ratio of 4:1 CBD:THC is the most effective for both neuropathic and inflammatory pain. Each individual is different, however—for some, a 1:1 ratio of CBD:THC can be more effective, and others prefer a high-THC strain when it can be tolerated. Each patient’s tolerance and sensitivity will differ, and through titration the correct strain and ratio combination can be found.
58. Rock EM, Bolognini D, Limebeer CL, et al. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol. 2012;165:2620–2634. doi: 10.1111/j.1476-5381.2011.01621.x. [PMC free article] [PubMed] [CrossRef]
To meet legal standards in the United States, CBD oil and other products may contain up to 0.3% THC; low enough to avoid all psychoactive effects, but enough to potentially appear on a sensitive drug test. Kat’s Naturals, however, sells CBE products of the utmost purity, containing 0% THC, and free from pesticides, chemicals, and contaminants. The company works with organic hemp cultivated in the Netherlands, and extracts its CBD using a broad-spectrum critical CO2 process, retaining a high amount of omega 3’s and 6’s (heart-healthy fats), vitamins, and phytochemicals. Kat’s Naturals is also big on using synergistic essential oils- also organic- to enhance their CBD’s therapeutic effects. The best CBD for anxiety in their lineup is Relax, a tincture that combines 300 mg CBD, Organic Hempseed oil, and wild orange essential oil, along with Hops oil, a potent calming botanical which has been used to promote sleep since ancient times. Kat’s Naturals recommends this product explicitly as a great CBD for anxiety, as well as for promoting sound sleep, making this an excellent choice for anxiety-induced insomnia.
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