During the summer I changed my licenced provider to one who offers an exceptional, high-CBD strain they call Avidekal. Taking this can noticably improve my mental state to the point that I have experimented not taking it at all for a week, whereupon the loss of homeostasis begins to occur with more frequency. This month I made a butter from it so I can easily consume it every day before work without having to vaporize.
Really sorry to hear you can not use our products due to Curcumin. Regarding hemp vs marijuana… yes this is an ongoing debate and the truth is that it's a fairly new debate and a lot of science is needed to make any claims. Yet, we can tell you without a shadow of a doubt that CBD is coming from Hemp along with over 100 different components such as other cannabinoids, terpenes and trade compounds. And thousands of people are able to experience the benefits. Maybe you saw the recent multi-part series on CNN? They were featuring Hemp CBD. CBD in it's whole plant and "entourage effect" is definitely the way to go… stay clear of the isolates or the 99.9% pure cbd products. We proudly use full plant extracts with all parts of the plant. And they are very effective. Anyone that is claiming that Hemp CBD is not as effective should talk to the thousands of families that are finding significant benefits (we will are not allowed to make claims but you can find thousands of people speaking up online about the benefits of Hemp derived CBD). Thanks for your question. You might look into Liposomal CBD, While it does not have the active ingredients our products to, and they use a completely different way to make CBD more bioavailable, it might be good alternative. All other product have to add or remove something to make CBD more bioavailable… in our case, we add a powerful antioxidant/ anti inflammatory herb of Curcumin from Turmeric.

^ Klein C, Karanges E, Spiro A, Wong A, Spencer J, Huynh T, Gunasekaran N, Karl T, Long LE, Huang XF, Liu K, Arnold JC, McGregor IS (November 2011). "Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats". Psychopharmacology. 218 (2): 443–457. doi:10.1007/s00213-011-2342-0. PMID 21667074.
Always start with the micro dose to test sensitivity and go up as needed within the dosing range before going to the next, until symptoms subside. The micro to standard dose is usually recommended to treat depression. Vaporized or smoked cannabis is recommended for relief of immediate symptoms, or a boost in dosage, and it can also be useful for sleep issues. Sublingual sprays or tinctures taken as liquid drops take effect quickly and last longer than inhaled products.
This taboo, which started around the same time that the US government outlawed cannabis, continues to slow down the progress for medical research around CBD. The FDA and DEA refuse to change their stance on cannabis, which is quite odd considering the US government holds onto a patent that highlights the benefits of CBD. Ultimately, all of this taboo and restrictions have inhibited extensive research around CBD and all the other cannabinoids in cannabis. (Cannabis is known to have 85+ different cannabinoids, many of them potentially having health benefits)
Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.

A 2006 study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice. CBD benefits also showed a significant reduction of plasma levels of pro-inflammatory cytokines. A histological examination of the pancreatic islets of the CBD-treated mice revealed significantly reduced insulitis. (16)


My question is specifically regarding CBD interactions with the endocannabinoid or limbic system and a mention made in your post regarding homeostasis. In April of this year I got a tube of "high CBD" oil which was foul tasting and made me gag. It did not sit well and my digestion went off. The company said that there was nothing wrong but by the end of the month I was in trouble. I stopped taking CBD and basically had an emotional breakdown. I went to a therapist to find out how and why I had basically lost homeostasis – precisely how I summarized my condition.
Of all the reasons that people use CBD today, pain is the most common. The same can be said of cannabis in general. In the United States, over seventy million people suffer from chronic pain, which is defined as experiencing over one hundred days per year of pain. Physicians differentiate between neuropathic (usually chronic) and nociceptive pains (usually time-limited), and cannabis works on most neuropathic and many nociceptive types of pain. A number of studies have demonstrated that the endocannabinoid system is both centrally and peripherally involved in the processing of pain signals.[383] Most discussions of using CBD for pain treatment suggest that finding the right dosage is critical.

@gailb I am in SC where it can only be prescribed for last days of cancer pain because they don't care if they get "addicted". I will not get on my soapbox, but I would much prefer being addicted to marijuana as there have never been any scientific studies that prove a physical addiction to marijuana as opposed to opiates. Maybe a psychological dependence, but two very different animals. However, I do believe the CBD oil that does not contain THC is legal federally and in all states.
Your pancreas secretes the hormones glucagon and insulin to regulate blood sugar by signaling your liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. While THC primarily increases glucagon and blood sugar, CBD lowers insulin levels, and it is this CBD action that helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and have lower rates of type II diabetes than non-users, and is also why some diabetics find that marijuana makes it easier to manage their blood sugar.
Most people do not associate cognitive health issues like anxiety, depression, brain fog, ADD, ADHD, and autism with inflammation, but it turns out that is exactly what the research is finding. There is actually a whole field of research known as the cytokine model of cognitive function studying how inflammation messes with our brains and may cause anxiety disorders. One finding is that elevated levels of NF kappa B (NFkB), an inflammatory bad guy, is associated with anxiety while people with lower levels of NFkB often have lower rates of anxiety.
There are numerous wonderful resources on (but not restricted to) the web regarding CBD, the major phytocannabinoid which has added a whole extra dimension to cannabis-related studies, medication, and dietary supplementation. On the other hand, as is often the case with a novel matter, there is also a great deal of misinformation regarding its benefits.
Many people are tempted to believe that products that contain CBD only are the best, thinking that using just CBD alone is a more effective treatment. While products that contain single-molecule CBD, meaning that you won’t find any other compounds, are already provided as medicines, they are not exactly more efficient than whole plant extract CBD oil, when it comes to therapeutic effects.
Two additional studies in this area were done using CBD oil. In the first one, 214 participants would take 0.9 to 2.3 grams of oil per 1 pound of body weight. CBD successfully reduced seizures by a median of 36.5%. The second study focused on children who suffered from Dravet syndrome. Dravet syndrome is a type of epilepsy that happens in early infancy. Normally high temperatures and fevers trigger it. The results of the second study showed that CBD oil reduced seizures significantly.
I wanted to know something about your part in the absorption of CBD. You talked about how CBD is non water-soluble and the best way to get the full effect is to either take a large amount OR vaporize it which you considered to be annoying or unnecessary. I on the other hand have no quarrels with doing this as I am an occasional smoker. Since you didn’t elaborate much on vaporizing, does this imply that it is still an adequate route to getting a better effect of CBD?

Answering the question “what is CBD oil” would be incomplete without mentioning the many CBD oil benefits. In addition to positively affecting the endocannabinoid system, CBD has been the focus of more than 23,000 published studies about cannabinoids in relation to various medical indications including anxiety, epilepsy, inflammation, cancer and chronic pain to name few. For a more comprehensive look at these and other studies, visit our medical research and education page. 
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