I have/had ovarian/primary peritoneal cancer. I used thc/cbd oil pills I self made from the start. I am supposedly their “poster child”. I went thru with chemo and surgery. Oh that horror! But when I tried to tell two seperate doctors, the surgeon was all about it, and my oncologist threw a fit and said it was an anecdote. There are more than 100 studies at the NIH govt website.
My husband is 52 and has brain atrophy. There is no history of Dementia in his family and they haven’t found anything else wrong with him. Trying to save his life but Ativan is the only thing that works to keep him semi-calm so he can be in a facility that can care for him 24/7. What CBD oil, if any, do you recommend and how much should he take with the Ativan at first to eventually be able to get him off that awful medication?
Cooper recently got funding from the National Institutes of Health for a study looking at cannabinoids — including CBD in isolation — as a substitute for opioids, and numerous other clinical trials of CBD are underway. It will be several years before results are available, but these studies should help clarify both what benefits the substance may provide and any side effects it may come with. Most of the adverse effects so far associated with cannabis, such as impairments in short-term memory, coordination and judgment,2 come from products that contain THC as well as CBD, Cooper said, but we need to do more studies to find out for sure whether CBD has fewer risks. Studies are also needed to identify the best way to administer and dose CBD. “I get emails from people asking me what dose of CBD to use, and the truth is, we really don’t know,” Cooper said.
Cannabidiol also works with anxiety by boosting our own endocannabinoid levels, meaning that we can naturally produce more of the things inside of us that put us in a good mood without needing extra things like CBD. Another interesting side effect of CBD with anxiety is that CBD actually boosts our own natural production of endocannabinoids such as anandamide.
 S. Maione, F. Piscitelli, L. Gatta, D. Vita, L. De Petrocellis, E. Palazzo, V. de Novellis, and V. Di Marzo, “Non-psychoactive Cannabinoids Modulate the Descending Pathway of Antinociception in Anaesthetized Rats through Several Mechanisms of Action,” British Journal of Phramacology 162, no. 3 (2011): 584. doi:10.1111/j.1476-5381.2010.01063.x.
CBD does not appear to have any psychotropic ("high") effects such as those caused by ∆9-THC in marijuana, but may have anti-anxiety and anti-psychotic effects. As the legal landscape and understanding about the differences in medical cannabinoids unfolds, it will be increasingly important to distinguish "medical marijuana" (with varying degrees of psychotropic effects and deficits in executive function) – from "medical CBD therapies” which would commonly present as having a reduced or non-psychoactive side effect profile.
The cannabis plant contains a unique group of carbon compounds often referred to a phytocannabinoids. The most common ingredient is THC, which creates the euphoric high effect. Due to the THC element in the plant, marijuana is often associated with a stoner stigma of people only wanting to get high. But that is far from the truth. Cannabis also contains other medicinal compounds including cannabinol, cannabigerol, cannabidiol, and cannabichromene.
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12. Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors. In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist, and this action may be involved in its antidepressant, anxiolytic, and neuroprotective effects. It is an allosteric modulator of the μ- and δ-opioid receptors as well. The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.
The studies done on CBD oil have a pretty wide dose range (anywhere from a few milligrams to hundreds of milligrams). I suggest starting at the lower end (around 10 milligrams) and slowly increasing over a few weeks or months to see what works for you. Some people also do well with splitting the dosage throughout the day instead of taking the dose all at once. As with everything, it is always a good idea to talk with your prescribing doctor if you are on any medications. CBD is generally very safe, but there are some pharmaceutical medications CBD oil could potentially interact with and increase or decrease the pharmaceutical drugs' effectiveness.
Then there is the matter of which part of the plant is used. THC tends to be more concentrated in the leaves of the plant, while CBD in its stem and seeds. It should be noted that these aspects are relative. Some degree of agreement exists that for the purest CBD, the stalk of a hemp plant (varieties of cannabis generally grown for fiber manufacturing, low in THC), or much less often the seeds. Taking into account the fact that CBD supplements are usually in an oil form, one may fathom the origins of the nearly ubiquitous hemp oil dietary supplements.
Even if you live in a state where marijuana use is legal, the federal Drug Enforcement Administration still classifies the CBD extract as a Schedule 1 substance — the DEA's most restricted category. According to the agency, "Schedule I drugs, substances or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse."
The researchers leading many of the studies on marijuana extracts and obesity are affiliated with the UK’s GW Pharmaceuticals, which makes me cringe that pharmaceutical companies are going to make some kind of very expensive CBD-based weight loss drug. But regardless of motive, in these studies, the researchers found that the two compounds, THCV and cannabidiol, boosted metabolism, and reduced levels of liver fat, and blood cholesterol. These same compounds also made mice more sensitive to insulin, protected the cells that produce insulin, and increasing metabolic rate – all while suppressing the appetite. Nice.
Using CBD oil for anxiety, or any condition, requires finding the right dose and delivery method. Not everyone feels comfortable vaping, likes the taste of CBD gummies, or can swallow CBD capsules. Cannabidiol Life has the widest range of CBBD products and dosage points of any source included in this ranking, from CBD Terpin Wax, to Extreme Strength CBD Gummy Worms, to CBD body butter, and even CBD-infused water. Cannabidiol Life uses hemp grown organically in Colorado, and extracts its CBD using organic ethanol. In addition to full-spectrum CBD oil, many of their products incorporate other therapeutic botanicals, such as Lavender and St. John’s Wort. Among the many products offered, the best CBD for anxiety at Cannabidiol Life is their vape liquid, tinctures and capsules. Cannabidiol Life’s 250 mg CBD vape oil offers fact-acing relief, and comes in a 15 flavors, from chocolate to guava, and can be used with the Cannibidiol Life’s disposable vape pen. For long-lasting relief, try their 25 mg CBD capsules or CBD tinctures, which are available in strengths of 250 mg, 750 mg, 1,500 and even 3,000 mg per fluid ounce- the highest concentration of CBD available anywhere.
It should also be noted that, because CBD oil is mostly unregulated, products may be incorrectly labeled. To that end, a study published in the Journal of the American Medical Association in 2017 found that nearly 70 percent of all CBD products sold online are mislabeled and that a number of products contain a significant amount of THC. Since THC can aggravate anxiety and make your heart beat faster than normal, it’s possible that using CBD oil that contains THC might make your anxiety worse.
CBD Living Water is expensive at $5.00 per bottle with 2 servings. It has no flavor (the tincture had a sweet weird flavor I didn't like) and is easy to drink. I only used 4 bottles to help me through my withdrawal. I don't use it now, but I will if I have anxiety in the future. I am impressed with how helpful it was in my withdrawal. I think it would help in withdrawal from cigarettes too. I did that 34 years ago though.
58. Rock EM, Bolognini D, Limebeer CL, et al. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol. 2012;165:2620–2634. doi: 10.1111/j.1476-5381.2011.01621.x. [PMC free article] [PubMed] [CrossRef]
Bacon had said that I might need to try two full droppers worth of the oil to really feel its benefits. I knew that I had an incredibly busy and stressful day ahead of me—I needed to fit in a five mile run before work, had lots to do at the office, was scheduled for a busy event in the middle of the day, and had a 2-hour meditation class later that night which would require a lot of mental clarity. Tentatively, I squirted two droppers of CBD oil into my bulletproof coffee and sipped away.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
Because it provides the body with a calming effect, lemon balm is also used for nervous agitation, sleeping problems, functional gastrointestinal complaints, menstrual cramps and urinary spasms. It is thought that the volatile oils in lemon balm contain chemicals that relax muscles, particularly in the bladder, stomach, and uterus, thereby relieving cramps, gas, and nausea. Because of its calming effect without the potential to create the side effects of a sedative, lemon balm is also widely used to treat stress, anxiety and insomnia. This ability, along with lemon balm’s antiviral and anti-autoimmune characteristics have also made it useful for the treatment of thyroid issues chronic fatigue syndrome.