Can cannabis help treat psoriasis? The active cannabinoids in cannabis may be an effective treatment for psoriasis. Research shows that they offer potential health benefits that could relieve the symptoms of psoriasis. They may be able to reduce inflammation and itching, control pain, and even heal wounds. Learn more about cannabis for psoriasis here. Read now
Epidemiological studies of various neuropsychiatric disorders indicate that a higher CBD content in chronically consumed cannabis may protect against adverse effects of THC, including psychotic symptoms, drug cravings, memory loss, and hippocampal gray matter loss [115–118] (reviewed in [119]). As THC acutely induces anxiety, this pattern may also be evident for chronic anxiety symptoms. Two studies were identified, including an uncontrolled retrospective study in civilian patients with PTSD patients [120], and a case study in a patient with severe sexual abuse-related PTSD [121], which showed that chronic cannabis use significantly reduces PTSD symptoms; however, these studies did not include data on the THC:CBD ratio. Thus, overall, no outcome data are currently available regarding the chronic effects of CBD in the treatment of anxiety symptoms, nor do any data exist regarding the potential protective effects of CBD on anxiety potentially induced by chronic THC use.
Research is beginning to show that CBD is different than other well-studied cannabinoids. All cannabinoids act as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behavior. CB1 receptors are widely distributed, but are particularly abundant in areas of the brain, including those concerned with movement, coordination, pain and sensory perception, emotion, memory, cognition, autonomic and endocrine functions. (2)
It’s easy to love Bluebird Botanicals as a company. They support organic, sustainable and fair farming practices. They use Current Good Manufacturing Practices (CGMPs) and give generous employee benefits. They donate to charities, from autism research to homeless outreach. They offer deep discounts to disabled, veteran and low-income customers. It’s also easy to love their high-quality and reasonably-priced products. Bluebird Botanicals starts with high-terpene, organic hemp grown in Colorado, then uses environmentally-friendly friendly CO2 or alcohol extraction processes friendly CO2 or alcohol extraction processes. The company third-party lab tests its products, and makes the results of each batch’s labs public. With such pure products and conscientious practices, it’s no wonder the company was named “#1 Hemp CBD Company” at the 2016 Cannabist Awards. Bluebird’s oral CBD extracts are a good long-lasting CBD for anxiety, with three formulations offered in strengths of 250 or 1,000 mg. The “Classic” and “Complete” blends are both good, but the “Signature” blend boasts the most therapeutic ingredients. This CBD concentrate features hemp extract in hemp oil (containing raw and heated cannabinoids plus steam-distilled hemp terpenes) combined with and cold- pressed black seed oil, and wildcrafted frankincense extract, a known calming botanical. Bluebird’s CBD oil extract capsules, another good option for anxiety, have 15 mg of broad-spectrum, cannabinoid-rich, hemp blended with hempseed oil. For the fastest anxiety relief, Bluebird’s CBD 333 mg vape liquid is the preferred choice. While some companies flavor theirs with intense candy flavors, Bluebird’s grown-up therapeutic vape liquid is mildly fruity.
Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.
The manufacturer will probably give you a recommended dosage, but bear in mind that this isn’t set in stone. What you need to find is your own minimum effective dose. “Minimum effective dose” is a medical term which refers to the amount of a substance you need for the results you want, and above which, the substance doesn’t increase in effectiveness.
Good morning! Reading through your article, I'm completely impressed and thinking of the various clinical applications (that depressed patient, that anxious one, my arthritic knees!) for the CBD's. THEN you talk about your product, the combination of co-factors sounding really great, but the nano-particles alarm me. There is a fair amount of research about the hazards of nano-particles in cleaning and cosmetic products, I'm wary of ingesting them for fear of nano-sized items going afield of where I'm intending them to go.
Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, M.D., clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger. This is why Amanda Oliver, 31, a career consultant in Charleston, SC, pops a CBD gummy bear each night before bed. “I used to lie there tossing and turning as my mind raced from work projects to whether I had set the home alarm,” Oliver says. One piece of candy with 15 mg of CBD is enough to shut off her brain and facilitate sleep. She also swears by the CBD oil she takes at the height of her period, which she says quells her debilitating cramps.

Several complexities of the eCB system may impact upon the potential of CBD and other CB1R-activating agents to serve as anxiolytic drugs. First, CB1R agonists, including THC and AEA, have a biphasic effect: low doses are anxiolytic, but higher doses are ineffective or anxiogenic, in both preclinical models in and humans (reviewed in [33, 45]). This biphasic profile may stem from the capacity of CB1R agonists to also activate TRPV1 receptors when administered at a high, but not low dose, as demonstrated for AEA [46]. Activation of TRPV1 receptors is predominantly anxiogenic, and thus a critical balance of eCB levels, determining CB1 versus TRPV1 activation, is proposed to govern emotional behavior [27, 47]. CBD acts as a TRPV1 agonist at high concentrations, potentially by interfering with AEA inactivation [48]. In addition to dose-dependent activation of TRPV1 channels, the anxiogenic versus anxiolytic balance of CB1R agonists also depends on dynamic factors, including environmental stressors [33, 49].
According to the National Institute of Mental Health, approximately 15 million adults in the United States have social phobia and about 6.8 million have a generalized anxiety disorder. Traditional treatment usually involves counseling and medications. Treatment with CBD may be better than anti-depressants because it acts quickly and does not cause side effects or withdrawal symptoms.
In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.
On September 4, 2003, on my husband’s birthday, I had surgery at Cedars Sinai in Los Angeles. I spent the next day, our 19th wedding anniversary in ICU. The pathology report came back an Oligodendroglioma grade 2. The surgery was an apparent success and neither radiation nor chemotherapy were recommended. However, since it’s unlikely every cancer cell can be detected and removed, and the nature of gliomas are to grow back over time, it was necessary to continue MRI monitoring every 3 months. Living from MRI to MRI had become our “normal”.
CBD has been in the news before, as a possible treatment for epilepsy. Research is still in its early days. Researchers are testing how much CBD is able to reduce the number of seizures in people with epilepsy, as well as how safe it is. The American Epilepsy Society states that cannabidiol research offers hope for seizure disorders, and that research is currently being conducted to better understand safe use.

Scientists have made a lot of progress in understanding how CBD produces its calming, pain-reducing, anti-inflammatory effects in the body—and there’s still more to learn. We know that CBD interacts with many different receptors, proteins, and other chemicals in the brain. These interactions create changes in the activity of neurotransmitters, hormones, and other cells throughout the brain and body. Through these interactions, CBD appears to be able to affect many of the body’s functions, from sleep-wake cycles and emotional regulation to inflammation, pain perception, and seizures.
So to gain a higher production of THC in a field of cannabis plants, you simply take away the male plants so the females can’t be pollinated, and to lower THC production, you keep the male and female plants together. Plants used for CBD oil or CBD capsules or hemp oil or hemp protein or your hippie neighbor’s tie-dyed hemp headwear meet the international standards of less than 1% THC.

Oral consumption is recommended as it usually lasts the whole night. Always start with the micro dose to test sensitivity and go up as needed within the dosing range before going to the next, until symptoms subside. The micro to standard dose is usually recommended to treat insomnia and sleep apnea. When relaxing indica strains are used with higher THC levels, a dose of 5–10 mg is usually sufficient. Other people find they need larger doses, such as 15–40 mg. CBD taken as a tincture or edible will aid in a restful six to seven hours of sleep. This type of disorder varies widely from one patient to the next. Often, one needs to perform some experimental research and try strains of different CBD:THC ratios to figure out how CBD oil benefits their sleep and the best protocol.


Did you get an answer for this? I have the exact same scenario. I'm treating my TN with Tegretol, and recently tried CBD. I think I took too much and there are some weird drug interactions with Tegretol and I felt quite stoned....was alone and talking to myself in my head thinking I was Einstein. It freaked me out a bit but I think I took too much. I'm trying lower doses again as recently my TN seems to be resisting the meds, although I have had a lot of emotional stress, which seems to be a trigger. Thanks!! Anna
When pain is localized, topical products can be applied. These can be made using CBD-dominant cannabis as well as THC strains. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive. These may be available as CBD oils, ointments, salves, or other forms, and with varying ratios of CBD and THC (a ratio of 1:1 is often recommended as ideal for skin application). The skin has the highest amount and concentration of CB2 receptors in the body.
Hi, I have had spondylolisthesis since age 11 which left me with extreme nerve pain...restless leg syndrome. Had 3 spinal ops and also had hip surgery 2 years ago. have asthma and hypothyroidism. I can deal with everything else but this nerve pain is insane. Used Gabapentin for 9 years and now its not in the market in Nairobi, Kenya where I live. Am on Lyrica, which is not working. I started Cbd oil in August but now found my body has become immune to the effects of pain releif I was getting. Can anyone suggest what strength oil/cbd supplement I should aim for? Currently am making flapjacks with weed, have one every night but this makes me high which I dont want. I still wake up in pain at night, please help.
Nevertheless, as populations age all across the globe, constant pain brought on by chronic illnesses in the elderly will surely become a matter of public health and compassion. A 2008 study inquired on the efficacy of cannabinoids other than THC in pain management. Painkillers with cannabinoids proved to be well tolerated, with minimum side-effects, and a prospect for low long-term toxicity. Furthermore, a combination of cannabidiol and opioids is thought to be the breakthrough of the future in palliative care.[24]
I’m permanently bloated and have been for nearly a year. At best, I look slightly pregnant – at worst I look nearly full-term. As you can imagine, my self confidence and body image have plummeted, I can’t fit in any clothes and my social life is non existent. My diet was horrendous but, after working with a nutritionist for a year, it’s pretty much perfect now. I’ve had blood and stool tests and tried various ‘solutions’ and supplements as recommended by nutritionist – but to no avail. Most recently, I’ve tried kambo; three treatments in a lunar cycle. Again, no change whatsoever.
For example, cytokines are the signaling proteins synthesized and secreted by immune cells upon stimulation. They are the modulating factors that balance initiation and resolution of inflammation. One of the mechanisms of immune control by CBD during inflammation is stopping cytokine production by immune cells and lowering cytokine production by the T-helper cells Th1 and Th2 (which are interestingly the same cells in which overactivity can contribute to autoimmune issues and food intolerances). The inflammatory compound interleukin-6 (IL-6) can also be decreased in the presence of CBD.
CBD oil is made by mixing the extracted CBD or cannabidiol from the cannabis or marijuana plant (Cannabis Sativa) with coconut or hemp seed oil. CBD oil possesses cannabidiol; while THC is psychoactive, CBD is not, thereby helping relieve pain, treating anxiety and depression, fighting cancer, reducing anxiety. It also improves the quality of sleep, boosts appetite, and optimizes digestion.
Hi, In your wonderful CBD overview above you state that the reason you started using CBD oil in the first place was to lower your cortisol levels. Did you succeed? If you are comfortable with doing so can you share the ‘before’ levels and the ‘after’ levels? Or maybe just the amount of the drop (average)..?? And, was this CBD product you now sell the one that you were using then?

Cannabis has shown to have positive effects on people suffering from epilepsy and multiple sclerosis. A research conducted in the University College of London, it is also effective in dealing with multiple other neurological conditions like the Dravet syndrome and Parkinson’s disease. It prevents neurodegeneration and cognitive decline, thereby helping those suffering from Alzheimer’s.
Hi, I have had spondylolisthesis since age 11 which left me with extreme nerve pain...restless leg syndrome. Had 3 spinal ops and also had hip surgery 2 years ago. have asthma and hypothyroidism. I can deal with everything else but this nerve pain is insane. Used Gabapentin for 9 years and now its not in the market in Nairobi, Kenya where I live. Am on Lyrica, which is not working. I started Cbd oil in August but now found my body has become immune to the effects of pain releif I was getting. Can anyone suggest what strength oil/cbd supplement I should aim for? Currently am making flapjacks with weed, have one every night but this makes me high which I dont want. I still wake up in pain at night, please help.
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