Welcome to Mayo Connect. I am a Volunteer Mentor and not a medical professional. As such I can offer the benefit of my personal experience, as can others on this site, but not medical diagnoses nor medical opinions. We strive to help each other with the understanding that we are all different and what works for me may not work for you. I have gotten so much good from participating in Mayo Connect that I love it.
Relevant studies in animal models are summarized in chronological order in Table ​Table1.1. CBD has been studied in a wide range of animal models of general anxiety, including the elevated plus maze (EPM), the Vogel-conflict test (VCT), and the elevated T maze (ETM). See Table ​Table11 for the anxiolytic effect specific to each paradigm. Initial studies of CBD in these models showed conflicting results: high (100 mg/kg) doses were ineffective, while low (10 mg/kg) doses were anxiolytic [59, 60]. When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose–response curve, with anxiolytic effects observed at moderate but not higher doses [61, 90]. All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [62, 65], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Campos et al. [66] showed that in rat, CBD treatment for 21 days attenuated inhibitory avoidance acquisition [83]. Long et al. [69] showed that, in mouse, CBD produced moderate anxiolytic effects in some paradigms, with no effects in others.
There has been a fair amount of confusion surrounding the legality of CBD oil. But while the vast majority of cannabinoids are controlled substances under the Misuse of Drugs Act, rest assured that CBD oil is legal across the UK for medicinal purposes, provided it has been derived from an industrial hemp strain that is EU-approved. These strains contain very little to no THC (the psychoactive cannabinoid).
It’s nice to hear that CBD Hemp Oil is not a fraud. I understand that research has been slowed by the government in claiming hemp to be a schedule one drug. I had no idea that the government holds a patent that highlights the benefits of CBD. Preliminary research is better than no research and what I read is all very promising and empowering regarding multiple afflictions where CBD may be helpful. We have to keep up the flow of information about the cannabis plant and CBD to the general public so that at some point in time it will be de-criminalized. I know it’s hard to overcome big pharma and $$$, but I remain hopeful.

Nature’s Script offers a wide range of CBD oil products. Tinctures are available in 30mL containers and 300mg, 600mg, 1000mg, 2,000mg, and 4,000mg concentrations. These products come in watermelon or peppermint flavors. Nature’s Script recommends a beginning dose of 5mg to 10mg per day, and to gradually increase the dose until the desired effects are reached. Nature’s Script also sells CBD capsules and vape juice, as well as gummies and mixing syrup for those who enjoy edibles and a pain-relief topical sold in one- and four-ounce containers. These products do not contain any THC and pose no risk for drug test takers.
Hi Lauren I've just started today with 250mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well. Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve. Thank you Lyn
A research conducted by Ethan B Russo, GW Pharmaceuticals, WA, USA, suggests that CBD oil interacts with the protein cells in the body and sends chemical signals to your brain and immune system through a number of stimuli. This helps the cells positively respond to chronic pain. This oil is regularly suggested for people with inflammation and back pain because of its painkilling quality.
FDA DISCLOSURE Representations regarding the efficacy and safety of Rosebud CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here (https://www.ncbi.nlm.nih.gov/pubmed/22625422) and here (https://www.ncbi.nlm.nih.gov/pubmed/18728714) to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD Oil based on the expertise of relevant professionals. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new dietary supplement program. The Cannabidiol (CBD) in Rosebud CBD is a natural constituent of industrial hemp plant and grown in the United States of America. Rosebud CBD does not sell or distribute any products that are in violation of the United States Controlled Substances Act (US CSA). All products contain less than 0.3% THC. All products are legal in all 50 states.
At this moment you would believe that hemp CBD oil will make you high, which is a normal conclusion. However, even not the best CBD oil doesn’t have this side effect. The substance which makes you high is tetrahydrocannabinol or THC and it is present in marijuana. On the other hand, when properly extracted, CBD oil doesn’t contain this chemical, therefore its use won’t make you high. Regardless of the fact how many and how often you use CBD oil, the same effect will be provided, without the high issue.
Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.
Anyways, now we’re about to get to the good stuff, specifically things that I figured health-minded readers like you would actually find helpful, such as hormone balancing, de-stressing, enhanced sleep, fat loss, etc. But if you want to simply stop reading now, and take a side-track to go peruse the more than 20,000 articles published in peer reviewed journals that show the medical efficacy of CBD for a variety of other conditions in addition to what I’ve listed here, then knock yourself out.
CBD Vape Oil is very popular and can be used with a suitable vaporizer. Since this oil is generally viscous, it needs a device that can work with it. Therefore, it cannot be used with all vaporizers. Make sure you have a suitable vaporizer before using a CBD vape oil. CBD Vape oils have different concentrations and flavors. Adding terpenes also contributes to the effect.
A team of scientists, herbalists and nutritionists develops their formulas, and the hemp used to make them is grown organically in Denmark. The company maintains strict quality control through chemical-free processing and third party labs testing, with results available to consumers through the Endoca website. Of theirs many products, the best CBD for anxiety is Endoca’s CBD oil capsules or oral drops. Each is cold-extracted, containing terpenes, vitamins, ketones, amino acids, and co-nutrients, and is available in strengths of 5- 10 mg per dose
Last year, the National Academies of Sciences, Engineering and Medicine released a nearly 500-page report on the health effects of cannabis and cannabinoids. A committee of 16 experts from a variety of scientific and medical fields analyzed the available evidence — more than 10,000 scientific abstracts in all. Because so few studies examine the effects of CBD on its own, the panel did not issue any findings about CBD specifically, but it did reach some conclusions about cannabis and cannabinoids more generally. The researchers determined that there is “conclusive or substantial evidence” supporting the use of cannabis or cannabinoids for chronic pain in adults, multiple sclerosis-related spasticity (a kind of stiffness and muscle spasms), and chemotherapy-induced nausea and vomiting. The committee also found “moderate” evidence that cannabis or cannabinoids can reduce sleep disturbances in people with obstructive sleep apnea, fibromyalgia, chronic pain and multiple sclerosis, as well as “limited” evidence that these substances can improve symptoms of Tourette’s syndrome, increase appetite and stem weight loss in people with HIV/AIDs, and improve symptoms of PTSD and anxiety.
Former Denver Broncos quarterback Jake Plaummer takes a dose of cannabidiol in Colorado in 2016. CBD oil, often dispensed under the tongue with a dropper, has been regulated as a supplement in the U.S., not a medicine. So strength and purity may vary from brand to brand, or even bottle to bottle, scientists say. Aaron Ontiveroz/Denver Post via Getty Images hide caption
Rule #2 – Be consistent with your dosing. Don’t start small and then jump to higher doses. It’s important that your body gets accustomed to the CBD, so gradually increase the amount over time. Also, don’t get discouraged if you do not notice effects immediately – some people have said it took them up to two weeks of daily use before they started noticing positive results.

As noted, CBD has been found to have a bell-shaped response curve, with higher doses being ineffective. This may reflect activation of TRPV1 receptors at higher dose, as blockade of TRPV1 receptors in the DPAG rendered a previously ineffective high dose of CBD as anxiolytic in the EPM [66]. Given TRPV1 receptors have anxiogenic effects, this may indicate that at higher doses, CBD’s interaction with TRPV1 receptors to some extent impedes anxiolytic actions, although was notably not sufficient to produce anxiogenic effects.
The evidence is rapidly stacking up on the healing properties of the Marijuana plant. I’m excited for the future of Medical Marijuana and I feel a strong responsibility to spread this information. I hear so many misconceptions about this amazing medicinal plant that I feel i need to tell my story to anyone who is interested and my prayer is that it will be received with an open mind and a compassionate heart.
As someone dealing with anxiety — hi pals, isn't this pool getting crowded? — all day, every day, taking CBD oil sounded like something that was at least worth a shot. So, I contacted Charlotte's Web by the Stanley Brothers, a CBD hemp oil company based in Colorado. Their hemp oil had positive reviews, which is good for me and my tattered memories of freshman year. They kindly sent me some of their Everyday Advanced Oil, which they recommend taking 0.6 ml of twice a day. I decide to try it for a week.
“Pre-clinical evidence largely shows that CBD can produce beneficial effects in AD, PD and MS patients, but its employment for these disorders needs further confirmation from well-designed clinical studies. CBD pre-clinical demonstration of antiepileptic activity is supported by recent clinical studies in human epileptic subjects resistant to standard antiepileptic drugs showing its potential use in children and young adults affected by refractory epilepsy.” View Source
Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011, February 9). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-1226. Retrieved from http://www.nature.com/npp/journal/v36/n6/full/npp20116a.html?foxtrotcallback=true
Sativex, an oral spray containing both CBD and THC, can treat MS-induced pain. During one study, researchers gave Sativex to 47 participants with MS. Results were largely positive. Patients who used this spray felt notably better. Their muscle and walking spasms decreased, and they felt pain relief. Thanks to studies such as this one, several countries approved using Sativex in MS treatment.
It was actually a bad bout of jet lag after a trip to California that inspired me to finally test out the CBD oil (I'll admit that my weed-based reservations kept me from trying it for the first few months). Knowing that the oil had also helped people with sleep issues, I squeezed one full dropper of the Everyday Plus oil onto my tongue, per the instructions, and waited.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
In one of the most complete human clinical trials to date, researchers studied the effects of a standardized extract of ashwagandha on the negative effects of stress, including elevated levels of the stress hormone cortisol. The results were impressive, with participants showing increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being…
When medical marijuana became a thing in Seattle, before full legalization, many of my friends found relief from their darker moods with cannabis. At that time, I didn’t have a MMJ card to buy the medical stuff, but a buddy gave me some CBD oil he wasn’t using and I took it in the winter. The grey Seattle rain wasn’t getting to me anymore. I would smile a lot more and it helped me get through a serious break-up and transition in my life. I remember at the time hearing cases like this: http://seattle.cbslocal.com/2014/02/05/study-suicide-rates-fell-in-states-where-medical-marijuana-is-legal/ . How suicide rates dropped in states where medical and recreational use became legal.

I am acting caregiver for my wife who for the past 3 years has suffered from acute anxiety and depression which all started with a fall resulting in a broken hip. She has since then broken the other hip. At age 74 now the anxiety is detrimental to her recovery as she feels she can’t preform the smallest task. I appreciate your site I just finished reading as I am trying to educate myself on this approach to help to regain her self confidence. Thanks for your time snd efforts are help people like us. John
Best known for their role in beer brewing, the female flowers of hop are being increasingly used in supplements for insomnia, anxiety, and menopausal symptoms. In addition, research on their components has revealed new activities with promising clinical applications. Read below to learn more about hops’ components, health benefits, side effects, and interactions with drugs […]

CBD and THC interact with body cells by activating the cannabinoid receptors. By transmitting signals throughout our bodies, these receptors cause different physiological effects. Some cannabinoids are beneficial to us, while others cause undesirable psychotropic effects in our bodies such as “highs” or depression. Some of these substances cause both. There are as yet no studies that show undesirable effects from Cannabidiol, which is why it is legal worldwide. However, many studies show that CBD causes only desirable effects or no effects at all. Certain studies also show that CBD protects against the negative effects of THC. Note that a whole lot of research on Cannabidiol is still in the pipeline.

Its sad to know the history behind the weed, I hope the government stop sabotage the good things in order to profit, and this product could be more affordable to all people like paracetamol is. Stop hiding the true and making us puppets..how many will die from diseases and manipulation until they change? Is sad to know the true but makes me happy to know people like you, Helping people to awake and be cured by this cruel world ..

Researchers have also found that ashwagandha helps support the growth of nerve cell dendrites, which allow these cells to receive communications from other cells, and that ashwagandha helps promote the growth of both normal and damaged nerve cells, suggesting that the herb may boost healthy brain cell function as well as benefit diseased nerve cells. So we’re talking a “nootropic” smart drug type effect. 
Several complexities of the eCB system may impact upon the potential of CBD and other CB1R-activating agents to serve as anxiolytic drugs. First, CB1R agonists, including THC and AEA, have a biphasic effect: low doses are anxiolytic, but higher doses are ineffective or anxiogenic, in both preclinical models in and humans (reviewed in [33, 45]). This biphasic profile may stem from the capacity of CB1R agonists to also activate TRPV1 receptors when administered at a high, but not low dose, as demonstrated for AEA [46]. Activation of TRPV1 receptors is predominantly anxiogenic, and thus a critical balance of eCB levels, determining CB1 versus TRPV1 activation, is proposed to govern emotional behavior [27, 47]. CBD acts as a TRPV1 agonist at high concentrations, potentially by interfering with AEA inactivation [48]. In addition to dose-dependent activation of TRPV1 channels, the anxiogenic versus anxiolytic balance of CB1R agonists also depends on dynamic factors, including environmental stressors [33, 49].
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
Of course, if you’re a regular podcast listener or you read my recent article on the “The Effect Of Weed On Exercise: Is Marijuana A Performance-Enhancing Drug?“, then you already know that subsequent to the legalization of weed in my home state of Washington, I’ve been experimenting with edible tetrahydrocannabinol (THC) for exercise performance, and also experimenting with vaporizing indica-rich strains of marijuana for creativity, relaxation and sleep.
…when the cannabinoids and terpenoids in CBD are mixed with the isolated curcuminoids of a high-curcumin containing turmeric plant, the bioavailability of the CBD absolutely explodes. This means that if you’ve used CBD oil before in the absence of a curcuminoid blend from turmeric, you probably only felt about 1/5 to 1/10 of the actual effects of the CBD, since CBD by itself is very poorly absorbed.
Here is a statement from one of the studies concerning CBD and glaucoma and was presented as an opening statement in the Future Direction section of the study.  It states, “Cannabinoids have the potential of becoming a useful potentially relievement for glaucoma, as they seem to have neuroprotective properties and effectively reduce intraocular pressure.”
And then I woke up on the concrete, a worried crowd gathered around me. “You had a seizure,” my friend said gently as I blinked my eyes, trying to process this new information.  I remember it was warm that night because I was wearing a sundress, and when I finally regained consciousness my first worry was that my dress flew up and everyone could see my underwear.

Despite being the subject of countless controversies, use of marijuana for medical purposes seems to be gathering nationwide acceptance. The study and advancement of medical marijuana have come a long way since its ban in the early 1930s. Now, researchers have proof showing marijuana and its chemically related compounds having numerous health benefits.
27-year-old Bekkii Spain from Sligo in Ireland told Cosmopolitan UK how taking CBD oil made an invaluable difference to her intense anxiety. She began having regular panic attacks back in 2015 due to an uncontrollable fear of her throat closing up. But with counselling being far in the horizon and prescribed medication failing to work for her, Bekkii's anxiety only worsened, and eventually she was admitted to her local psychiatric hospital.
I am having some major issues with major anxiety and major depression that seems to be treatment resistant. I am currently on 75mg of Zoloft, 12.5mg of Seroquel for sleep, 5 to 10 mg of Valium a day and several vitamins as well. I have tried a number of different anti depressants. Nothing seems to be helping much. Out of desperation I have been exploring other options. My question is can I use the oil with all these other meds. Clearly I can’t just stop them but am hoping if I could get the anxiety and depression under control then I could wear off the pharma meds. If you can’t answer this question could you direct me to someone who could. Thanks!!’
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.

Squeeze the top of your dropper to fill CBD oil into the pipette. Dispense CBD oil under the tongue and swish it around if you like. Alternatively, you can also let the oil sit under the tongue. CBD oil drops taste better, especially if you have a flavored oil version. Add the number of drops you need to get your daily dose of CBD as instructed by the manufacturer. CBD oil should be absorbed into the body system after holding it in the mouth for 60 to 90 seconds before swallowing.


Hemplife Today makes quality CBD products affordable and accessible. That’s great news for those suffering from anxiety, as the expense of taking therapeutic CBD for anxiety (which may mean regular small, doses for some, and occasional large doses for others) can become quite costly. Hemplife makes reasonable pricing a top priority, offers quantity discounts, and also runs regular promotions, with reduced prices for new customers or product bundles. Hemplife Today begins with pesticide-free, first-cut, non-industrial, and non-GMO hemp, and uses a CO2 extraction method. The company calls their CBD oil “CannnazALL,” because of its broad array of hemp compounds, achieved through a proprietary “NanoTech Infusion Process” which re-infuses CBD extract with beneficial whole-plant Terpenes, Phytocannbinoids and plant Botanicals with the goal of capitalizing on the “Entourage Effect”. The best fast-acting CBD for anxiety in their inventory is their vape liquid, while their oral CBD tincture and capsules can have a long-lasting effect. Hemplife Today’s affordable and potent, fruit punch-flavored CBD vape liquid contains 60 mg of CBD per 5 ml vial. Their tincture contains 250 mg CBD per ounce, plus refreshing peppermint oil. Gelcaps are a great choice for thse in search of a portable, pre-measured dosing option, and have 25 mg per capsule.

A team of scientists, herbalists and nutritionists develops their formulas, and the hemp used to make them is grown organically in Denmark. The company maintains strict quality control through chemical-free processing and third party labs testing, with results available to consumers through the Endoca website. Of theirs many products, the best CBD for anxiety is Endoca’s CBD oil capsules or oral drops. Each is cold-extracted, containing terpenes, vitamins, ketones, amino acids, and co-nutrients, and is available in strengths of 5- 10 mg per dose
This turn is due to a comprehensive 2015 study aimed at two notoriously difficult manifestations of epilepsy – Dravet syndrome and Lennox-Gastaut syndrome – most often encountered in children. Seizure frequency was found to decrease between 54 percent and 67 percent for the six months cannabidiol medication was used, although a small part of individuals did not continue after three months, as their condition did not improve.
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.
A bit of online digging led me to realize that the active ingredient in Charlotte's Web Everyday Plus Hemp Oil, the product I'd been offered to test, was the chemical compound CBD, which stands for Cannabidiol. Unlike THC, the other crucial compound in hemp and marijuana plants, CBD does not produce the psychoactive effects that make you feel "high"; instead, it actually eases anxiety and makes you less likely to freak out.
A 2016 review of animal studies indicated that cannabidiol has potential as an anxiolytic for relief of anxiety-related disorders and fear.[11] Reviews of preliminary research showed cannabidiol has potential for improving addictive disorders and drug dependence, although as of 2016, they indicated limited high-quality evidence for anti-addictive effects in people.[93][20][94]
Cannabidiol can be taken into the body in multiple different ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as an oil containing only CBD as the active ingredient (no added THC or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, or as a prescription liquid solution.[1][3]
@gailb I am in SC where it can only be prescribed for last days of cancer pain because they don't care if they get "addicted". I will not get on my soapbox, but I would much prefer being addicted to marijuana as there have never been any scientific studies that prove a physical addiction to marijuana as opposed to opiates. Maybe a psychological dependence, but two very different animals. However, I do believe the CBD oil that does not contain THC is legal federally and in all states.
It is well known that people who consume cannabis in other forms notice increased appetite, famously called “the munchies”. However, cannabis essential oil can help regulate your appetite and induce hunger, while also stimulating your digestive system to operate at a regular level. This can help people who want to gain weight quickly, particularly after an extended illness or injury.
Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.
Jessica is a vegetarian who loves riding her bike and practicing yoga. She is trying her best to be more conscious about the nutrients she puts into her body and enjoys trying new recipes. A big fan of up-cycling, Jess loves cooking with as many fresh herbs, spices and veggies as possible. What we put in, is what we get out. Let's treat ourselves compassionately, and with balance in mind.

Juliana Birnbaum is trained as a cultural anthropologist and skilled in four languages and has lived and worked in the U.S., Europe, Japan, Nepal, Costa Rica and Brazil. In 2005 she founded Voices in Solidarity, an initiative that partnered with Ashaninka indigenous tribal leaders from the Brazilian Amazon to support the development of the Yorenka Ãtame community-led environmental educational center featured in Sustainable [R]evolution. She was the first graduate of the Cornerstone Doula School, one of the most rigorous natural birth programs in the U.S., focusing on a holistic model of care. She is engaged variously as writer, editor, teacher, midwife assistant and mother when not attempting new yoga poses or learning how to garden.
CBD may help reduces REM behavior disorder in people with Parkinson’s disease. REM behavior disorder is a condition that causes people to act out physically during dreaming and REM sleep. Typically, during REM, the body is largely paralyzed, a state known as REM atonia. This immobilization keeps sleepers from reacting physically to their dreams. In REM behavior disorder, this paralysis doesn’t occur, leaving people free to move—which can lead to disruptive sleep and to injuring themselves or their sleeping partners. Cannabis may also work to reduce pain and improve sleep quality in people with Parkinson’s disease.

Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[25][26] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[27] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[28]
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