Sativex, an oral spray containing both CBD and THC, can treat MS-induced pain. During one study, researchers gave Sativex to 47 participants with MS. Results were largely positive. Patients who used this spray felt notably better. Their muscle and walking spasms decreased, and they felt pain relief. Thanks to studies such as this one, several countries approved using Sativex in MS treatment.

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My FD recommended CBD oil some time ago but I never went with the idea due to the expense. She uses it a lot for other patients apparently and has seen good results but I am hesitant and I don’t know why. I am not helping my health issues with all this anxiety. I get agoraphobic, fatigued, can’t think straight either. Is it worth my trying it to you think. I am sick of popping Propanolol and Diazepam to try and control it. So desperate please can someone help. If I try, are there any side effects?
So, CBD oil is safe to use and it can be used even when you drive a car or you suffer from some other condition. But, we are focused on best hemp CBD oil for depression and anxiety. There have been several studies and plenty of research which all proved that this oil helps people who suffer from depression and anxiety. We said and, due to the fact, these two issues are usually linked together and a person will suffer from both of them. Below, we will explain how cannabis oil actually works and what to expect if you use it for treating anxiety and depression.
Mike, what kind of breast cancer (invasive ductal, I presume)? How many of her lymph nodes were positive? How big was the primary tumor? Reason I ask is that in women with Stage I or IIA tumors that are estrogen-and progesterone-receptor-positive and HER2-negative (ER+/PR+/HER2-) with three or fewer positive lymph nodes, there is a genomic assay test on a sample of the tumor, called OncotypeDX, that will tell doctors whether chemo is necessary or would even work at all. Medicare covers that test 100%.That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors(aka AIs: anastrazole, letrozole, or exemestane)which have as a side effect joint pain. CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.So don’t assume your mom’s cancer will require chemo; but if it does, CBD helps with those side effects as well. If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil (legal and over-the-counter in all 50 states). Some (though not most) medical oncologists will certify their own patients’ medical marijuana card applications so she need not seek out another doctor; and will advise the appropriate dose for her symptoms. Once she gets her card, the “budtenders” in the licensed dispensaries can advise her as to the right CBD product (with or without THC), strength, and dosage. If she lives in a state where recreational weed is legal, the “budtenders” in the marijuana shops can steer her to the right strength of CBD oil and the right dosage.

Trying to believe that if we let her hit ‘rock bottom’ she would finally quit drinking. All that happened was that she became really ill and had to be taken to hospital. She isn’t the type of alcoholic who can carry on some kind of life. When she drinks, that is all she does. She stays in her flat and drinks and smokes all night and all day until she physicality cannot cope. Then she has a few days off it, then it all starts again.


Growing up, Joe was plagued with a myriad of health issues such as gut problems, autoimmune issues, chronic fatigue, brain fog, insomnia, and general inflammation. Both conventional and alternative doctors weren’t able to help him, so he decided to fix himself. With lots of health questions and few satisfying answers, Joe decided to read every research paper he could get his hands on and conduct thousands of experiments on his own body in order to fix his health issues. Joe started SelfHacked in late 2013 when he successfully fixed all of his issues, and now it gets millions of readers a month looking to educate themselves about how they can improve their health. Joe is now a thriving author, speaker, and serial entrepreneur, founding SelfDecode & LabTestAnalyzer.
Cannabidiol can be taken into the body in multiple different ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as an oil containing only CBD as the active ingredient (no added THC or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, or as a prescription liquid solution.[1][3]
The Cannabis Health Index (CHI) is an evidence-based scoring system for cannabis (in general, not just CBD oil effects) and its effectiveness on various health issues based on currently available research data. Refer to cannabishealthindex.com for updated information. Using this rubric, the use of cannabis-based products for treating insomnia has a rating of likely probable efficacy based on the four studies available at press time (3.4 points).
Serotonin is a neurotransmitter that affects mood, social behavior, sleep, memory, appetite, and sexual function. It is believed that anxiety and depression occur when the brain isn’t properly using serotonin. 5-HT1A is a subtype of serotonin receptor, and CBD oil enhances 5-HT1A transmission. This allows for your brain to make use of the serotonin in the synaptic space, instead of it just going back into the brain. This is what makes CBD oil regulate your mood and reduce anxiety.
In 2013, the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin and insulin resistance among U.S. adults. The study included 4,657 adult men and women from the National Health and Nutritional Examination Survey from 2005 to 2010. Of the participants, 579 were current marijuana users and 1,975 were past users. The researchers found that current marijuana use was associated with 16 percent lower fasting insulin levels. They also found significant associations between marijuana use and smaller waist circumferences, a factor connected to the onset of diabetes symptoms. (17)
Fear and anxiety are adaptive responses essential to coping with threats to survival. Yet excessive or persistent fear may be maladaptive, leading to disability. Symptoms arising from excessive fear and anxiety occur in a number of neuropsychiatric disorders, including generalized anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and obsessive–compulsive disorder (OCD). Notably, PTSD and OCD are no longer classified as anxiety disorders in the recent revision of the Diagnostic and Statistical Manual of Mental Disorders-5; however, excessive anxiety is central to the symptomatology of both disorders. These anxiety-related disorders are associated with a diminished sense of well-being, elevated rates of unemployment and relationship breakdown, and elevated suicide risk [1–3]. Together, they have a lifetime prevalence in the USA of 29 % [4], the highest of any mental disorder, and constitute an immense social and economic burden [5, 6].

As you may know or as you may have forgotten (ha!) short term memory problems are really common with THC. That’s why the extremely funny, laugh-snorting joke you told last night is impossible to remember the next morning. Don’t worry, it probably wasn’t as funny as you thought it was last night. But a 2010 study found that CBD eliminates any memory loss problem from weed. In the study, researchers used plants bred for high CBD and low THC plants, and attributed this attenuation of memory loss to CBD’s role as a CB1 antagonist.
In one of the most complete human clinical trials to date, researchers studied the effects of a standardized extract of ashwagandha on the negative effects of stress, including elevated levels of the stress hormone cortisol. The results were impressive, with participants showing increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being…
Although anxiety disorders are generally treated with psychotherapy, medication, or a combination of the two, many people opt to forgo these standard approaches and self-treat with products like CBD oil. According to a survey published in Cannabis and Cannabinoid Research in 2018, almost 62 percent of cannabidiol users reported that they used CBD to treat a medical condition, with the top three conditions being pain, anxiety, and depression.
Parkinson’s disease. Some early research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson’s disease and psychosis. But taking a specific cannabis extract (Cannador) that contains THC and cannabidiol does not appear to improve involuntary muscle movements caused by the anti-Parkinson’s drug levodopa in people with Parkinson’s disease.
While there are many different pathways driving the positive health benefits of CBD, the center of its awesome abilities seems to be that CBD is a very effective natural anti-inflammatory. Chronic inflammation is really the commonality between most (and by most, I mean basically all) chronic health problems that we face today as a modern society. Cancer, heart disease, diabetes, autoimmune conditions, digestive issues, and hormonal problems are all inflammatory in nature. What the heck, right?
Our Full Spectrum Hemp Extract has endless possibilities as an add in, like in this berry smoothie 😍✨ Link in bio to purchase! . #fullspectrum #hempextract #cbd #cbdsmoothie #smoothies #berrysmoothie #lucefarm #cleaneating #healthydiet #healthandwellness #healthinspo #eatingwell #realsimple #morningmotivation #fruitforbreakfast #organic #organicfarmers #vermontgrown #cafes #coffeeshops #barista #healthyliving #mctoil #mct #coconutoilbenefits #fitness #plantmedicine #sustainableliving #refusethestraw #noplasticstraws
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[67][68] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[69] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[69] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[69]
In the United States, non-FDA approved CBD products are classified as Schedule I drugs under the Controlled Substances Act.[62] This means that production, distribution, and possession of non-FDA approved CBD products is illegal under federal law. In addition, in 2016 the Drug Enforcement Administration added "marijuana extracts" to the list of Schedule I drugs, which it defined as "an extract containing one or more cannabinoids that has been derived from any plant of the genus Cannabis, other than the separated resin (whether crude or purified) obtained from the plant."[63] Previously, CBD had simply been considered "marijuana", which is a Schedule I drug.[62][64]

I have tried NatureCBD and believe in the product. I particularly noticed alleviation in joint pain and reduction in stress – although stress reduction may have been supported by pain reduction. However, since I live in Canada and it is expensive to ship, I have been using CBD from a licensed medical marijuana facility. The effect is not as powerful as from NatureCBD. I had not really considered the bioavailability issue; perhaps that is the reason for the weaker effect. Or possibly it could be the other herbs added, or the synergistic effect. In any case, I am going to bite the bullet (at least my visa card will) and go back to NatureCBD.
As you may know or as you may have forgotten (ha!) short term memory problems are really common with THC. That’s why the extremely funny, laugh-snorting joke you told last night is impossible to remember the next morning. Don’t worry, it probably wasn’t as funny as you thought it was last night. But a 2010 study found that CBD eliminates any memory loss problem from weed. In the study, researchers used plants bred for high CBD and low THC plants, and attributed this attenuation of memory loss to CBD’s role as a CB1 antagonist.
You then take your first drop of CBD oil, wait 45 minutes, then ask the questions again. If you feel no different and there’s no change in the way you answer those questions, you increase the dose by small increments until you do notice a difference. You can continue this process over several days – and at some point, you’ll find that taking more doesn’t change your scores. That is your minimum effective dose.
Start with the smallest recommended dose on your CBD oil product, and gradually increase it until you experience the desired effect. Finding the best CBD oil dosage for anxiety can take several days to a couple of weeks. All of our bodies and situations are different, and finding the best balance may take time. For quickest results, talk to one of our Wellness Consultants.

I am thinking of trying CBD oil for my anxiety and insomnia. This has been ongoing since returning from Iraq a few years ago. I am now a Nursing student and feeling the lack of sleep now more than ever. I am currently taking Qualia and Organigi daily and off all prescription medications. I am already giving CBD to my old dog and it is helping her arthritis, just wanna cash in on this without it affecting my school negatively. What would be a good dosage for a 120 lb female to start at? I am very sensitive to medications and drugs, I even cut the Qualia dosage in half.
In the United States, the CBD drug Epidiolex has been approved by the Food and Drug Administration for treatment of two epilepsy disorders.[13] The U.S. Drug Enforcement Administration has assigned Epidiolex a Schedule V classification while non-Epidiolex CBD remains a Schedule I drug prohibited for any use.[14] CBD is not scheduled under any United Nations drug control treaties, and in 2018 the World Health Organization recommended that it remain unscheduled.[15]

Recently a friend gave my 80 year old father a small bottle of 550 MG CBD Oil to help him with some chemo side effects. My father does not want it so he gave it to me as he knows I have restless legs at night with tiny little muscle spasms like little fireworks going off in both lower legs from the knee down when I lay down to go to sleep at night.


According to the National Institute of Mental Health, approximately 15 million adults in the United States have social phobia and about 6.8 million have a generalized anxiety disorder. Traditional treatment usually involves counseling and medications. Treatment with CBD may be better than anti-depressants because it acts quickly and does not cause side effects or withdrawal symptoms.
Cannabis Oil: Cannabis oil is typically made from marijuana with a high THC percentage. Therefore, it must be purchased in an area where marijuana is legal or can be obtained with a prescription. The amounts of compounds, including CBD and THC, will drastically vary from product to product. Commercially produced cannabis oils will have more controlled concentrations of CBD and THC for medical purposes.
Due to the anti-inflammatory properties of cannabidiol, insulin resistance (the chief metabolic problem for patients with type 2 diabetes) is reduced, leading to a better prognosis thanks also to the lower incidence of dead tissue. Ever since the discovery of CBD in the 1990’s, speculation existed to its effect on other types of receptors (not just cannabinoid receptors) which could be manipulated and included in the treatment of some cardiovascular diseases like atherosclerosis. In light of these speculations, researchers at the University of Tel Aviv (walking in the footsteps of the “father” of cannabinoid research, Dr. Raphael Mechoulam) demonstrated a 30 percent blood flow increase in rodents with areas of dead tissue in the heart muscle.[22]
The nutrition and supplement industry—which includes CBD products—is almost wholly unregulated. “The concentrations in products are only approximate, and I don’t know how well they’re tracked,” Szaflarski says. Even if you could absolutely trust a product’s label—and many CBD manufacturers, aware of the current scrutiny on their industry, go to great lengths to assure consumers of the quality of their products—there aren’t a lot of concrete facts when it comes to the type or amount of CBD a person should take for a specific ailment or aim.
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[67][68] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[69] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[69] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[69]
CBD, or cannabidiol, is an extract from cannabis. Helping to reduce anxiety, overactive mind, paranoia, inflammation, and a host of other problems in the body, CBD for insomnia is a great choice. This is due to CBD’s ability to regulate sleep cycles, helping to decrease activity in the brain and lead you to a restful, relaxed state of mind. For those with major insomnia, CBD proves to be a powerful cure — especially if you would prefer not to take prescription drugs or sleep aids.
Studies in humans, including many of those cited below, have demonstrated that CBD dosage reduces anxiety (once again, compared to the increased levels of anxiety that THC produces), and that when you combine CBD with THC, it takes the anxiety edge off THC. This is due to the action of CBD on 5HT1A and TRPV1 receptors, both of which are involved in mitigating the anxiolytic, panic and fear responses to stress.
So your plasma concentrations of THC increase when you’re using CBD, resulting in a greater amount of THC available to receptors and increasing the effect of THC in a dose-dependent manner (which means the more CBD you use, the more THC becomes available). But along with this increase, CBD also acts as an antagonist at the a cannabinoid receptor called GPR55 in the caudate nucleus and putamen sections of your brain, reducing paranoia-like effects or heart-beat racing from weed.
In a small study published in the journal JCI Insight in 2017, researchers observed that CBD may help prevent stress-related changes in blood pressure. For the study, nine healthy male volunteers took a single dose of either CBD or a placebo. Compared to those given the placebo, those treated with CBD had lower blood pressure both before and after experiencing a stressful event.
Oral CBD products with a ratio of 20:1 or higher and administered as drops, capsules, or edibles can be very effective in treating pain, especially the inflammatory type. Most discussions of treating pain with CBD suggest that finding the right dosage is critical. Always start with the micro dose to test sensitivity and go up as needed within the dosing range by body weight until symptoms subside. The micro to standard dose is usually recommended to treat pain, but patients need to carefully monitor their condition and experiment to find the right formula; 10–40 mg of CBD or CBD+THC together is usually enough.
Kevin Sabet, a psychiatrist at the University of Florida’s Drug Policy Institute, presented a six-point plan whose purpose is accelerating officially sanctioned serious research in the properties of cannabidiol and relaxing barriers for private actors interested in the matter, who would nevertheless pursue this avenue in a grayer area and thus, less safe.

CBD (Cannabidiol) is a potent, non-psychoactive cannabinoid found in hemp oil. It is typically extracted from industrial hemp plants that are naturally high in CBD and other phytochemicals. It is the most prevalent of over 80 different cannabinoids found in natural hemp. It is commonly used for its therapeutic properties. Cannabidiol is responsible for a wide-range of positive health benefits through its interaction with the body's own endocannabinoid system.
To meet legal standards in the United States, CBD oil and other products may contain up to 0.3% THC; low enough to avoid all psychoactive effects, but enough to potentially appear on a sensitive drug test. Kat’s Naturals, however, sells CBE products of the utmost purity, containing 0% THC, and free from pesticides, chemicals, and contaminants. The company works with organic hemp cultivated in the Netherlands, and extracts its CBD using a broad-spectrum critical CO2 process, retaining a high amount of omega 3’s and 6’s (heart-healthy fats), vitamins, and phytochemicals. Kat’s Naturals is also big on using synergistic essential oils- also organic- to enhance their CBD’s therapeutic effects. The best CBD for anxiety in their lineup is Relax, a tincture that combines 300 mg CBD, Organic Hempseed oil, and wild orange essential oil, along with Hops oil, a potent calming botanical which has been used to promote sleep since ancient times. Kat’s Naturals recommends this product explicitly as a great CBD for anxiety, as well as for promoting sound sleep, making this an excellent choice for anxiety-induced insomnia.
Daniel Clauw, MD, professor of anesthesiology at the University of Michigan, believes that CBD may have real benefits for people living with chronic pain. He cites a recent clinical trial from pharmaceutical company Zynerba (for which Dr. Clauw has consulted) that found that a CBD-derived topical drug provided pain relief to patients suffering from knee osteoarthritis.
No, hemp oil is not the same as cannabis oil. All-natural hemp oil is obtained by cold pressing of hemp seeds whereas cannabis oil is obtained by separating the resins from cannabis flowers. Their uses and chemical composition are quite different. Cannabis oil is much higher in THC (tetrahydrocannabinol) content, which has certain effects, whereas hemp oil tends to be higher in CBD (cannabidiol) levels.

In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.

Why don’t pharmaceutical companies want to see CBD help the general public? If they’re after our general welfare and health, wouldn’t they want any sort of cure to make its way into our hands? Why we know so little about the benefits of CBD Oil? Find out more about CBD treatments, CBD legal status, where to buy CBD Oil, how to recognize high-quality CBD Oil and how to use this pure hemp extract on our Hemp, Health and Wellness Blog.
Correct, I am not a doctor, and this is not to be interpreted as medical advice. I would recommend you talk to a licensed medical professional about all of this. I'm not sure what the product is so I can't recommend guidelines for taking it. If you're referring to my product, NatureCBD, as a general guideline, start with 2-3 capsules a day and not exceeding 5 tablets in 24 hours. I have personally seen no contraindications for CBD and blood pressure meds.
A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability (which causes leaky gut) associated with such environments. (18)
Szaflarski explains that cannabis contains about 500 different compounds, some of which—including CBD and THC—interact with certain chemical receptors in the human nervous system. But unlike THC, CBD isn’t psychoactive—meaning it doesn’t cause any kind of a high. Despite that, the US Drug Enforcement Agency classifies CBD (and other cannabis compounds) as schedule I substances, making their sale illegal in many states.
CBD has also been shown to enhance extinction of contextually conditioned fear responses. Extinction training involves repeated CS exposure in the absence of the US, leading to the formation of a new memory that inhibits fear responses and a decline in freezing over subsequent training sessions. Systemic CBD administration immediately before training markedly enhanced extinction, and this effect depended on CB1R activation, without involvement of TRPV1 receptors [65]. Further studies showed CB1Rs in the infralimbic cortex may be involved in this effect [82].

It’s nice to hear that CBD Hemp Oil is not a fraud. I understand that research has been slowed by the government in claiming hemp to be a schedule one drug. I had no idea that the government holds a patent that highlights the benefits of CBD. Preliminary research is better than no research and what I read is all very promising and empowering regarding multiple afflictions where CBD may be helpful. We have to keep up the flow of information about the cannabis plant and CBD to the general public so that at some point in time it will be de-criminalized. I know it’s hard to overcome big pharma and $$$, but I remain hopeful.

Recently, lemon balm produced an unexpected result: it greatly increased the ability to concentrate and perform word and picture tasks. In a study at Northumbria University in England, students were tested for weeks while using either lemon balm or a placebo. The students did significantly better on the tests after taking lemon balm and continued to post improved scores for up to six hours after taking the herb. The students taking lemon balm were noted to be calmer and less stressed during the tests.


As noted, CBD has been found to have a bell-shaped response curve, with higher doses being ineffective. This may reflect activation of TRPV1 receptors at higher dose, as blockade of TRPV1 receptors in the DPAG rendered a previously ineffective high dose of CBD as anxiolytic in the EPM [66]. Given TRPV1 receptors have anxiogenic effects, this may indicate that at higher doses, CBD’s interaction with TRPV1 receptors to some extent impedes anxiolytic actions, although was notably not sufficient to produce anxiogenic effects.
Thirty minutes later, I was surprised by how subtle the effect was. While I expected a hazy nodding-off effect similar to melatonin's, the oil simply relaxed my body ever so slightly—my heart stopped pounding against my chest, my legs stopped kicking beneath my sheets, my mind stopped racing. I wasn't sure if it was the oil or the late hour, but eventually, physical relaxation gave way to mental relaxation, and I drifted off to sleep.
The oral use of cannabis and CBD for anxiety appears in a Vedic text dated around 2000 BCE,[238] and it is one of the most common uses of the plant across various cultures. While THC can increase anxiety in some patients, it lowers it in others. However, CBD effects have been shown to consistently reduce anxiety when present in higher concentrations in the cannabis plant. On its own, CBD has been shown in a number of animal and human studies to lessen anxiety. The stress-reducing effect appears to be related to activity in both the limbic and paralimbic brain areas.
In a nutshell cannabinoids substances contained in the Cannabis plant, including Cannabidiol (CBD), THC and a whole lot of others. CBD and THC are phytocannabinoids, meaning that they are derived from plants. Other types of cannabinoids include endocannabinoids (produced in the body) and synthetic cannabinoids manufactured in laboratories. Each type of cannabinoid interacts with the body in a different way.
The 5-HT1A receptor (5-HT1AR) is an established anxiolytic target. Buspirone and other 5-HT1AR agonists are approved for the treatment of GAD, with fair response rates [50]. In preclinical studies, 5-HT1AR agonists are anxiolytic in animal models of general anxiety [51], prevent the adverse effects of stress [52], and enhance fear extinction [53]. Both pre- and postsynaptic 5-HT1ARs are coupled to various members of the Gi/o protein family. They are expressed on serotonergic neurons in the raphe, where they exert autoinhibitory function, and various other brain areas involved in fear and anxiety [54, 55]. Mechanisms underlying the anxiolytic effects of 5-HT1AR activation are complex, varying between both brain region, and pre- versus postsynaptic locus, and are not fully established [56]. While in vitro studies suggest CBD acts as a direct 5-HT1AR agonist [57], in vivo studies are more consistent with CBD acting as an allosteric modulator, or facilitator of 5-HT1A signaling [58].
Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.
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