"As far as I know, CBDs are compatible. My daughter was on several epileptic meds while using MMJ and CBDs. Also as you know CBDs often help with Type 2 diabetes, but not so much with Type 1. However you should continue to monitor closely. My numbers have dropped a little since using CBD. As far as adding CBD to your routine, as always, start slow and build."

CBD inhibited escape responses in the ETM and increased DPAG escape electrical threshold [68], both proposed models of panic attacks [95]. These effects partially depended on 5-HT1AR activation but were not affected by CB1R blockade. CBD was also panicolytic in the predator–prey model, which assesses explosive escape and defensive immobility in response to a boa constrictor snake, also partially via 5-HT1AR activation; however, more consistent with an anxiogenic effect, CBD was also noted to decrease time spent outside the burrow and increase defensive attention (not shown in Table ​Table1)1) [75, 86] . Finally, CBD, partially via CB1Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [89]. Anticompulsive effects of CBD were investigated in marble-burying behavior, conceptualized to model OCD [96]. Acute systemic CBD reduced marble-burying behavior for up to 7 days, with no attenuation in effect up to high (120 mg/kg) doses, and effect shown to depend on CB1Rs but not 5-HT1ARs [71, 74, 88].


For hemp-based CBD products, most folks have no problems with them getting into Canada. Canada that has specifically stated that they consider CBD whether it comes from hemp or medical marijuana to be a Scheduled II Drug, Class Scheduled II Drug, which means that it has reported medicinal benefits but they would like to control the regulation and the selling of those products. But I don't think they're regulating it too strictly.

It’s not just anxiety. Uncontrolled inflammation is also associated with depression and psychotic disorders. Lately I’ve been thinking about combining cannabinoid with low dose naltrexone an opioid receptor antagonist. My thinking is that since CBD also interacts with opioid receptors, as an allosoteric modulator, that by blocking those receptors we may get some novel interactions that I think may be beneficial for anxiety and other inflammatory related disorders.


It’s a truism to state that pain is an inevitable part of life. And it’s true that we all, from time to time, experience pain that is short-lived and treatable. But those who deal with chronic pain know the debilitating, life-sucking reality of this condition. And traditional medications often come with long lists of side effects which can be as debilitating as the pain itself.

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I have great interest in CBD and appreciate all the information provided, but I have one basic question regarding the nano-particle comparison especially since Bio availability and the ‘potential dangers of crossing the BBB’ by some in a concern. Simply how can you refer to the CBD ad a nano particle when, for reference, a sheet of paper is about 100,000 nanometers thick. A strand of human DNA is 2.5 nanometers in diameter. There are 25,400,000 nanometers in one inch. A human hair is approximately 80,000- 100,000 nanometers wide. This said, anyone who does any basic search (or research) will find that Nanoparticles are particles between 1 and 100 nanometers in size. You can see my concern with your comparison to a human hair (1/100th the width) is not even close; A ‘large’ nano-particle (100nm) would still be 1/800th the width of the most ‘thin’ human hair. Could you please clarify for me? Thank you!
Duchess was diagnosed with cancer in her right anal gland. When the cancer was removed it had spread to her left anal gland and was attached to her bowels. She was given 3 months to live. Since then I have had 2 vets check her glands and have had complete physical. She has a clean bill of health. I am so grateful to you. We are going to start on a maintenance program. I tell everyone how she has done. Thanks
I decided to try CBD when I was withdrawing from Tramadol, a synthetic opiate I had been taking for pain (with 2 other medications) for over a year. As I began slowly reducing my use, I experienced a lot of anxiety and muscle tremors in my legs especially. I know that using a marijuana medication meant that my pain doctor would not prescribe for me again, but I was getting off the pain medications one by one anyway, so I don't care.
My dad has severe advanced stage Dementia. Will CBD oil help him at this point? He is now refusing to eat any solid food, but will accept most drinks.In addition, he has lost a great deal of weight even though they're giving him Mega Shakes containing a full meals worth of proteins, etc. He gets at least 4 of these a day..some which he refuses. Is his Dementia too far gone for CBD oils to help him?
As the name suggests, Pure Hemp Botanicals is all about purity, going the extra mile to establish customer trust and transparency in this unregulated industry. The company controls the process “from soil to oil,” exercising exacting standards and rigorous testing at every phase. Pure Hemp Botanicals grows their non-GMO hemp organically in Colorado, and tests each batch for its cannabinoid profile and hemp extract potency. In an effort to create transparency, the company shares the lab results for each batch on its website, and consumers can even take a video tour of the growing and extraction process. For the treatment of anxiety, we recommend using Pure Hemp Botanicals’ CBD vape liquid for fast relief, and its tinctures, capsules, and teas for long-lasing effects. Vape liquids come in a range of strengths and a variety of flavors. There are concentrations of 500, 1,000 or 2,000 mg available, and 12 flavors. Kits with chagers, vape pens plus pre-filled liquid cartridges can be purchased as well. CBD tinctures in hemp seed oil are available in strengths of 300 mg, 750 mg, 1500 mg, or 3000 mg of cannabinoid extract. These are good for long-lasting relief, and include the full-spectrum of plant cannabinoids and terpenes, plus omega 3 and omega 6 fatty acids. Tinctures are available in doses of per package. The company’s vegan softgel capsules contain the same oils and extract in a portable form, and come in doses of 10 or 25 mg. Finally, an outstanding choice for calming is Pure Hemp Botanicals’ Chamomile Lavender CBD Tea. Both chamomile and lavender have established soothing and sleep-promoting properties, and this organic, loose-leaf tea blend boasts 30% industrial hemp, making it a great choice to combat anxiety-related insomnia.
Generally, new users start with one drop on the first day, to get an idea of how it affects them. Depending on the results, and what you’re using it for, you might thereafter take a lot more, or stay consistent. For anxiety, pain, and general health, around 2.5mg to 20mg is often recommended. For epilepsy, on the other hand, you might need as much as 200mg to 300mg.
Cannabidiol also works with anxiety by boosting our own endocannabinoid levels, meaning that we can naturally produce more of the things inside of us that put us in a good mood without needing extra things like CBD. Another interesting side effect of CBD with anxiety is that CBD actually boosts our own natural production of endocannabinoids such as anandamide.
Cannabinoid therapy is connected to the part of the biological matrix where body and brain meet. Since CBD (cannabidiol) and other compounds in cannabis are so similar to the chemicals created by our own bodies, they are integrated better than many synthetic drugs. According to Bradley E. Alger, a leading scientist in the study of endocannabinoids with a PhD from Harvard in experimental psychology, “With complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease.”[175]
Your pancreas secretes the hormones glucagon and insulin to regulate blood sugar by signaling your liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. While THC primarily increases glucagon and blood sugar, CBD lowers insulin levels, and it is this CBD action that helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and have lower rates of type II diabetes than non-users, and is also why some diabetics find that marijuana makes it easier to manage their blood sugar.
Bacon had said that I might need to try two full droppers worth of the oil to really feel its benefits. I knew that I had an incredibly busy and stressful day ahead of me—I needed to fit in a five mile run before work, had lots to do at the office, was scheduled for a busy event in the middle of the day, and had a 2-hour meditation class later that night which would require a lot of mental clarity. Tentatively, I squirted two droppers of CBD oil into my bulletproof coffee and sipped away.
The nutrition and supplement industry—which includes CBD products—is almost wholly unregulated. “The concentrations in products are only approximate, and I don’t know how well they’re tracked,” Szaflarski says. Even if you could absolutely trust a product’s label—and many CBD manufacturers, aware of the current scrutiny on their industry, go to great lengths to assure consumers of the quality of their products—there aren’t a lot of concrete facts when it comes to the type or amount of CBD a person should take for a specific ailment or aim.
Fill the dropper with the CBD oil, place the tip of the dropper under the tongue and drip in the desired amount. Let the CBD oil get adsorbed for 1-5 minutes before swallowing it. If you are having a hard time with the dosage or the number of drops when you drip it under your tongue, you can also use a spoon. Just put the desired amount of CBD oil on the spoon and try to put it under the tongue. Just lick off the remaining oil on the spoon. Due to the fine blood vessels and mucous membranes in the mouth, the CBD quickly enters the bloodstream and therefore has a good bioavailability.

CBD and THC interact with body cells by activating the cannabinoid receptors. By transmitting signals throughout our bodies, these receptors cause different physiological effects. Some cannabinoids are beneficial to us, while others cause undesirable psychotropic effects in our bodies such as “highs” or depression. Some of these substances cause both. There are as yet no studies that show undesirable effects from Cannabidiol, which is why it is legal worldwide. However, many studies show that CBD causes only desirable effects or no effects at all. Certain studies also show that CBD protects against the negative effects of THC. Note that a whole lot of research on Cannabidiol is still in the pipeline.
As you may know or as you may have forgotten (ha!) short term memory problems are really common with THC. That’s why the extremely funny, laugh-snorting joke you told last night is impossible to remember the next morning. Don’t worry, it probably wasn’t as funny as you thought it was last night. But a 2010 study found that CBD eliminates any memory loss problem from weed. In the study, researchers used plants bred for high CBD and low THC plants, and attributed this attenuation of memory loss to CBD’s role as a CB1 antagonist.

To access CBD oil, a solvent extraction process is required, which returns roughly 3-5 grams of oil per ounce of flower product used. Using grain or isopropyl alcohol as a solvent, you can strain the result of the mixture, leaving CBD oil behind. It is a lengthy process, and in countries where cannabis is legal, there are many places to access high-quality CBD oil.
Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effects, and CBD, which lacks these psychoactive effects. Preclinical and clinical studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties (see [11, 12, 16–19] for reviews). A review of potential side effects in humans found that CBD was well tolerated across a wide dose range, up to 1500 mg/day (orally), with no reported psychomotor slowing, negative mood effects, or vital sign abnormalities noted [20].
[193] N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet, and I. Bab, “Cannabidiol, A Major Nonpsychotropic Cannabis Constituent, Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts,” Journal of Mineral and Bone Research 30, no. 10 (October 2015): 1905–1913.
With that said, I'm definitely intrigued enough by the subtle effects to continue taking the oil and possibly even to up the dosage to the recommended two full droppers of the 30mL bottle per day for a week or so. Plus, I take comfort in knowing that it's an all-natural treatment for anxiety that's responsibly grown on family farms in Colorado. Something that's safe, legal, requires no prescription, and makes me less anxious, less scatterbrained, and more focused? I'm definitely on board.

Epidemiological studies of various neuropsychiatric disorders indicate that a higher CBD content in chronically consumed cannabis may protect against adverse effects of THC, including psychotic symptoms, drug cravings, memory loss, and hippocampal gray matter loss [115–118] (reviewed in [119]). As THC acutely induces anxiety, this pattern may also be evident for chronic anxiety symptoms. Two studies were identified, including an uncontrolled retrospective study in civilian patients with PTSD patients [120], and a case study in a patient with severe sexual abuse-related PTSD [121], which showed that chronic cannabis use significantly reduces PTSD symptoms; however, these studies did not include data on the THC:CBD ratio. Thus, overall, no outcome data are currently available regarding the chronic effects of CBD in the treatment of anxiety symptoms, nor do any data exist regarding the potential protective effects of CBD on anxiety potentially induced by chronic THC use.
The following medications and other supplements may interact with CBD. Effects may include increasing or decreasing sleepiness and drowsiness, interfering with the effectiveness of the medications or supplements, and interfering with the condition that is being treated by the medication or supplement. These are lists of commonly used medications and supplements that have scientifically identified interactions with CBD. People who take these or any other medications and supplements should consult with a physician before beginning to use CBD.
WR = Wistar rats; SM = Swiss mice; L-E HR = Long–Evans hooded rats; i.p. = intraperitoneal; dlPAG = dorsolateral periaqueductal gray; i.c.v. = intracerebroventricular; PL = prelimbic; IL = infralimbic; BNST = bed nucleus of the stria terminalis; CeA = amygdala central nucleus; SNpr = substantia nigra pars reticularis; CUS = chronic unpredictable stress; GSCT = Geller–Seifter conflict test; CER = conditioned emotional response; EPM = elevated plus maze; VCT = Vogel conflict test; CFC = contextual fear conditioning; RS = restraint stress; ETM = elevated T maze; PAG E-stim = electrical stimulation of the dlPAG; L-DT = light–dark test; SI = social interaction; OF = open field; MBT = marble-burying test; PS = predator stress; NSF = novelty suppressed feeding test; GABAA = γ-aminobutyric acid receptor A; dlSC = deep layers superior colliculus; REM = rapid eye movement; NA = not applicable
The Cannabis Health Index (CHI) is an evidence-based scoring system for cannabis (in general, not just CBD effects) and its effectiveness on various health issues based on currently available research data. Refer to cannabishealthindex.com for updated information and more about studies related to specific types of pain. Considering all of the studies together, which number over forty (for various types of pain), CBD and cannabis are shown to have a rating of likely probable efficacy. It is one of the best-substantiated medical uses of cannabinoids.
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[25][26] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[27] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[28]
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