Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011, February 9). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-1226.  http://www.nature.com/npp/journal/v36/n6/full/npp20116a.html?foxtrotcallback=true

And of course, THC is what most recreational weed users are looking for, which is probably why botanists have figured out since the 1960’s how to increase the amount of THC from around 3% to 5% in the 1960s to as much as 28% in our current decade. So yes, it’s true that we’re not smoking the weed our parents smoked, and one draw on a typical joint these days would probably knock your mom on her ass.
1.)  A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD conducted by Department of Psychiatry & Behavioral Sciences, Duke University Medical Center: The results are as followed… “Twenty-five (25%) percent of individual posts indicated that cannabis is therapeutic for ADHD, as opposed to 8% that it is harmful, 5% that it is both therapeutic and harmful, and 2% that it has no effect on ADHD.”  This was the first type of study done of its kind.  View Source
Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. We at Plus CBD Oil™ are proud of our innovative selection of products.
I am acting caregiver for my wife who for the past 3 years has suffered from acute anxiety and depression which all started with a fall resulting in a broken hip. She has since then broken the other hip. At age 74 now the anxiety is detrimental to her recovery as she feels she can’t preform the smallest task. I appreciate your site I just finished reading as I am trying to educate myself on this approach to help to regain her self confidence. Thanks for your time snd efforts are help people like us. John
[241] A. C. Campos, Z. Ortega, J. Palazuelos, M. V. Fogaça, D. C. Aguiar, J. Díaz-Alonso, S. Ortega-Gutiérrez, H. Vázquez-Villa, F. A. Moreira, M. Guzmán, I. Galve-Roperh, and F. S. Guimarães, “The Anxiolytic Effect of Cannabidiol on Chronically Stressed Mice Depends on Hippocampal Neurogenesis: Involvement of the Endocannabinoid System,” International Journal of Neuropsychopharmacology 16, no. 6 (2013): 1407–1419. doi:10.1017/S1461145712001502.

CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids. Until recently, THC (tetrahydrocannabinol) was getting most of the attention because it’s the ingredient in cannabis that produces mind-altering effects in users, but CBD is also present in high concentrations — and the medical world is realizing that its list of medical benefits continues to grow.
We have receptors for cannabinoids in the whole body, but the first type — CB1 — are very dense in the pain pathways of the brain, spine, and nerves. The second type — CB2 — is more important for the immune system but is also involved in inflammation. By gently acting on both pathways, our internal cannabinoids and CBD can balance both pain and inflammation [R+].
There are new CBD companies coming online every week – these span the range from truly awful to really great. So how to choose the best? The quality of the CBD oil itself is obviously the most important factor – and many companies do take the quality of their products seriously. To reward those companies, we gave more weight to the quality of the product than any other category.
Weight plays a role in the effects of CBD oil, and bottle size should be selected based on how much you weigh. Let’s say you weigh less than 130 pounds and desire light CBD oil effects; this means that 11 mg or less will probably suffice per dose, giving roughly 40 doses from a 450-mg concentration. If you weigh more than 230 pounds and desire strong effects, then this same concentration will supply roughly 10 doses. 

John Staughton is a traveling writer, editor, and publisher who earned his English and Integrative Biology degrees from the University of Illinois in Champaign, Urbana (USA). He is the co-founder of a literary journal, Sheriff Nottingham, and calls the most beautiful places in the world his office. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.
This taboo, which started around the same time that the US government outlawed cannabis, continues to slow down the progress for medical research around CBD. The FDA and DEA refuse to change their stance on cannabis, which is quite odd considering the US government holds onto a patent that highlights the benefits of CBD. Ultimately, all of this taboo and restrictions have inhibited extensive research around CBD and all the other cannabinoids in cannabis. (Cannabis is known to have 85+ different cannabinoids, many of them potentially having health benefits)
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Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects. CBD’s anxiolytic actions appear to depend upon CB1Rs and 5-HT1ARs in several brain regions; however, investigation of additional receptor actions may reveal further mechanisms. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. Current preclinical and human findings mostly involve acute CBD dosing in healthy subjects, so further studies are required to establish whether chronic dosing of CBD has similar effects in relevant clinical populations. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders.
Locsta....I share your pain of degenerative and bulging disk disease, along with fibromyalgia, chronic fatigue and arthritis. Absolutely no energy and chronic pain all day, every day. I'm curious as to what type and brand of the CBD oil you are taking and for how long have you been using it? I've been researching CBD oil for months and am quite confused!
Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Cannabidiol has shown to reduce anxiety in patients with social anxiety disorder and researchers suggest that it may also be effective for panic disorder, obsessive compulsive disorder, social anxiety disorder and post-traumatic stress disorder. (7)

While CBD is most commonly used to treat physiological symptoms, there’s a growing body of research that indicates it can also be used in the therapy of a range of mental health conditions, including anxiety. A study by the University of São Paulo found that CBD significantly reduces subjective anxiety, leading investigators to conclude that “These results suggest that CBD reduces anxiety in [social anxiety disorder] and that this is related to its effects on activity in limbic and paralimbic brain areas.”

He did my parathyroidectomy and he is the best there is in this field. He can tell you if you need a repeat surgery and if it will help. He fixes parathyroids that were operated on by other doctors all the time and does a splendid job. Fast, almost painless, perfect. Please call him. Please. You shouldn’t try to live with a botched parathyroidectomy. Believe me it is so super dangerous to your health. Bless you Mike.


So am I to assume, due to no response/deleted comment that my simple question was too difficult to answer? With all the technical & correct information you have on you GREAT website, can someone (?) not simply correct or acknowledge the FACT the your NOT using nano-particle size product? I am truly interesting (for my wife) in CBD, have done my research, and I love working with numbers which is why if found this discrepancy. Comments welcome, but avoidance is disturbing.

My mother was thinking about trying CBD because she heard it would help with her diabetes and I was wondering how good is CBD at controlling sugar levels as my mother has tried multiple insulin drugs and they might work for a while but then stop working from what I understand. She got her diabetes from the Growth Hormone Drug back in 2009 and she also got some type of rare mouth Tumor which the doctor did the surgery to remove it wrong and caused it to spread. Will this work at controlling her sugar levels as she gets both high and lows, for example, she once had her sugar levels so high that it was unreadable and the doctors were amazed that she was still alive plus she also gets lows sometimes. Also, because of diabetes, she has neuropathy where she is losing feeling in her toes and does not feel the heat from hot products when she picks them up, will this product also help with the neuropathy and any remaining tumor?
Very interesting article. I have terrible anxiety and nausea and I have been working with a Functional Medicine Practitioner for my gut issues, plus I have Hashimoto’s, under active thyroid, post menopause and also a mycotoxin issue. I wake up with anxiety and nausea every day, some days not quite so bad as others. I have absolutely no idea what is driving my anxiety. I am on SSRI’s and have been for years but they arn’t working that well anymore but I am on Seroxat so not looking to wean off because it’s the worst one on the market.
Your pancreas secretes the hormones glucagon and insulin to regulate blood sugar by signaling your liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. While THC primarily increases glucagon and blood sugar, CBD lowers insulin levels, and it is this CBD action that helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and have lower rates of type II diabetes than non-users, and is also why some diabetics find that marijuana makes it easier to manage their blood sugar.
Its sad to know the history behind the weed, I hope the government stop sabotage the good things in order to profit, and this product could be more affordable to all people like paracetamol is. Stop hiding the true and making us puppets..how many will die from diseases and manipulation until they change? Is sad to know the true but makes me happy to know people like you, Helping people to awake and be cured by this cruel world ..
A 2013 study that measured data from 4,652 participants on the effect of cannabis on metabolic systems compared non-users to current and former users. It found that current users had higher blood levels of high-density lipoprotein (HDL-C) or “good cholesterol.” The same year, an analysis of over seven hundred members of Canada’s Inuit community found that, on average, regular cannabis users had increased levels of HDL-C and slightly lower levels of LDL-C (“bad cholesterol”).
CBD has also been shown to enhance extinction of contextually conditioned fear responses. Extinction training involves repeated CS exposure in the absence of the US, leading to the formation of a new memory that inhibits fear responses and a decline in freezing over subsequent training sessions. Systemic CBD administration immediately before training markedly enhanced extinction, and this effect depended on CB1R activation, without involvement of TRPV1 receptors [65]. Further studies showed CB1Rs in the infralimbic cortex may be involved in this effect [82].

Research shows that CBD benefits include producing antipsychotic effects. It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs as seen in using behavioral and neurochemical techniques in animal studies. Additionally, studies show that CBD prevents human experimental psychosis and is effective in open case reports and clinical trials in patients with schizophrenia, with a remarkable safety profile. (6)
One critical factor you can use as a gauge to the quality is price. Expect to pay in the neighborhood of $50+ for a bottle of high quality CBD oil, though that’s not the only marker. It’s also important to investigate the company’s website and/or talk with a distributor because reputable dealers conduct independent lab tests and are committed to the quality of their product.
The reason so many people are interested in cannabis products that don’t make them high, proponents say, is that CBD helps with everything from pain and nausea to rheumatoid arthritis, cancer, Crohn’s disease, and dementia. CBD is anti-inflammatory, anti-anxiety, antibacterial, immunosuppressive, and more, says Joseph Cohen, D.O., a cannabis doctor in Boulder, CO.
Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effects, and CBD, which lacks these psychoactive effects. Preclinical and clinical studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties (see [11, 12, 16–19] for reviews). A review of potential side effects in humans found that CBD was well tolerated across a wide dose range, up to 1500 mg/day (orally), with no reported psychomotor slowing, negative mood effects, or vital sign abnormalities noted [20].
But from joint pain to irritable bowel syndrome to diabetic retinopathy, CBD has been shown to modulate both acute and chronic inflammatory issues via several different mechanisms, and from the research I’ve seen and cited below, it’s even more powerful than many of the commonly recommend natural remedies for inflammation, such as curcumin, fish oil, resveratrol, anti-oxidants, proteolytic enzymes, Vitamin C, etc.

Could cannabidiol help prevent tumors and other cancers before they grow? A 2012 study showed that animals treated with CBD were significantly less likely to develop colon cancer after being induced with carcinogens in a laboratory.[187] Several studies had already shown that THC prevents tumors and reduces them, including one in 1996 on animal models that found that it decreased the incidence of both benign and hepatic adenoma tumors.[188] In 2015, scientists analyzed the medical records of over eighty-four thousand male patients in California and found that those who used cannabis, but not tobacco, had a rate of bladder cancer that was 45 percent below the norm.[189] Topical products can be used to treat and prevent skin cancers. Continuing research is focused on the best ratio of CBD to THC and the most effective dose level in cancer prevention and treatment.


All MRI reports remained stable until November 2013 when my quarterly MRI came back showing regrowth of the tumor. My brain surgeon in Los Angeles recommended 4-6 months of chemotherapy, and if that didn’t work, another brain surgery to go in and clean up the regrowth would be considered. He also gave me anti-seizure medication for auras that had started to manifest as strong unexplainable odors. My doctor described this experience as an olfactory seizure. While researching Christopher’s Web cannabis oil as an alternative to the prescribed seizure medicine I also found out that cannabis oil was also showing promise as a cancer treatment and could be an alternative to chemotherapy.
A team of scientists, herbalists and nutritionists develops their formulas, and the hemp used to make them is grown organically in Denmark. The company maintains strict quality control through chemical-free processing and third party labs testing, with results available to consumers through the Endoca website. Of theirs many products, the best CBD for anxiety is Endoca’s CBD oil capsules or oral drops. Each is cold-extracted, containing terpenes, vitamins, ketones, amino acids, and co-nutrients, and is available in strengths of 5- 10 mg per dose
CBD and THC interact with body cells by activating the cannabinoid receptors. By transmitting signals throughout our bodies, these receptors cause different physiological effects. Some cannabinoids are beneficial to us, while others cause undesirable psychotropic effects in our bodies such as “highs” or depression. Some of these substances cause both. There are as yet no studies that show undesirable effects from Cannabidiol, which is why it is legal worldwide. However, many studies show that CBD causes only desirable effects or no effects at all. Certain studies also show that CBD protects against the negative effects of THC. Note that a whole lot of research on Cannabidiol is still in the pipeline.
This turn is due to a comprehensive 2015 study aimed at two notoriously difficult manifestations of epilepsy – Dravet syndrome and Lennox-Gastaut syndrome – most often encountered in children. Seizure frequency was found to decrease between 54 percent and 67 percent for the six months cannabidiol medication was used, although a small part of individuals did not continue after three months, as their condition did not improve.

Have a high-stress job with an important pitch or presentation coming up? The fear of public speaking or intimidating social interactions is one of the most common forms of anxiety. For some, social anxiety simply makes parties, work gatherings, or a daily job uncomfortable and exhausting. For others with social anxiety, it is a crippling fear that keeps them locked indoors and in isolation.
Most people do not associate cognitive health issues like anxiety, depression, brain fog, ADD, ADHD, and autism with inflammation, but it turns out that is exactly what the research is finding. There is actually a whole field of research known as the cytokine model of cognitive function studying how inflammation messes with our brains and may cause anxiety disorders. One finding is that elevated levels of NF kappa B (NFkB), an inflammatory bad guy, is associated with anxiety while people with lower levels of NFkB often have lower rates of anxiety.
CBD is a safe, long-term aid which is why it has gained such momentum and why our customers are turning to it for relief. CBD, scientifically known as cannabidiol, is a non-psychoactive, natural compound found in the hemp plant. When it interacts with the body’s endocannabinoid system, CBD provides powerful health benefits without the side effects of conventional drugs.
Leonard Leinow has three decades of experience growing and studying medical cannabis and brings a unique spiritual perspective to his work. In 2009, he formed Synergy Wellness, a not-for-profit medical cannabis collective in California. Synergy Wellness has over 3,500 members in its collective and is an artisan organization making hand-crafted organic and natural whole plant-based products. They are specialists in CBD (cannabidiol), the non-psychoactive portion of cannabis, and are pioneers in this aspect of the industry. Leinow is known for his proprietary blends of tinctures and medicine used for cancer and epilepsy patients.
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