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CBD exerts several actions in the brain that explain why it could be effective in treating anxiety. Before we dive in, it’s important to note that most research describing how CBD works is preclinical and based on animal studies. As the saying goes, “mice are not men” — and, results from animal studies don’t always neatly transfer to human therapies. However, preclinical studies provide insights that move us in the right direction:
Juliana Birnbaum is trained as a cultural anthropologist and skilled in four languages and has lived and worked in the U.S., Europe, Japan, Nepal, Costa Rica and Brazil. In 2005 she founded Voices in Solidarity, an initiative that partnered with Ashaninka indigenous tribal leaders from the Brazilian Amazon to support the development of the Yorenka Ãtame community-led environmental educational center featured in Sustainable [R]evolution. She was the first graduate of the Cornerstone Doula School, one of the most rigorous natural birth programs in the U.S., focusing on a holistic model of care. She is engaged variously as writer, editor, teacher, midwife assistant and mother when not attempting new yoga poses or learning how to garden.

A team of scientists, herbalists and nutritionists develops their formulas, and the hemp used to make them is grown organically in Denmark. The company maintains strict quality control through chemical-free processing and third party labs testing, with results available to consumers through the Endoca website. Of theirs many products, the best CBD for anxiety is Endoca’s CBD oil capsules or oral drops. Each is cold-extracted, containing terpenes, vitamins, ketones, amino acids, and co-nutrients, and is available in strengths of 5- 10 mg per dose
By eating healthy food and walking every day we both lost a needed 35 lbs. I never experienced the dreaded “munchies” that some get on this medicine.Smoking marijuana is reported to have an appetite stimulating effect. When I built up a tolerance to the THC, even though I was ingesting large amounts, I did not get an intense “high” like whatwould happen if a person were smoking it. For me, it produced a deep sense of well being.

Considering the complete non-addictiveness and safety of cannabis, Dr. James Hudson, PhD, Professor Emeritus, University of British Columbia Department of Pathology and Lab Medicine, has said that pharmaceutical companies have an enormous incentive to chemically recreate the natural compounds in marijuana and somehow sell a drug from it. You probably already know this, but pharmaceutical companies can’t patent a natural compound, but if they can make a synthetic compound that mimics ingredient from cannabis, they can formulate that as a drug and potentially make a lot more money off of it.


@parus i just got my certification for medical marijuana. Upon buying what was recommended I was given CBD oil, I’ve not been on it a week yet today will be my fourth day of using it. It takes about 1/2 hour to work but it seems to help. They also gave me a cannabinol patch to use at night fir the severe itch in my head from the shingles. Also a vape two puffs as needed for the itch break through which I have not tried yet. I’m a bit anxious about using it.


Because letting an anxiety disorder go untreated can deplete your quality of life and lead to physical health problems (such as digestive conditions), it’s crucial to consult a doctor rather than self-treating. If you’re thinking of using CBD oil to help manage your anxiety (and it is legal where you live), make sure to talk with your doctor about whether it's right for you.
Being legal globally, Cannabidiol is a controlled substance only in Canada. Its misunderstood status results largely from misinformation because there is too little known about CBD, and because of its resemblance to THC. The controlled status of CBD was largely due to the fact it was believed that Cannabidiol was a precursor to the formation of THC. Only as recently as the 1980’s did scientists discover that CDB is actually completely unrelated to the formation of THC. CBD has since been declared a legal cannabinoid and is safe to consume in any amount and concentration. 
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
Francesca Fusco, MD, a dermatologist based in New York City, recently told Health that CBD oil is a rich source of fatty acids and other skin-healthy nutrients, and that it may improve hydration and minimize moisture loss. A few studies have also suggested that CBD oil may inhibit the growth of acne, although this hypothesis has only been tested in laboratory cell cultures—not in actual humans.
Francesca Fusco, MD, a dermatologist based in New York City, recently told Health that CBD oil is a rich source of fatty acids and other skin-healthy nutrients, and that it may improve hydration and minimize moisture loss. A few studies have also suggested that CBD oil may inhibit the growth of acne, although this hypothesis has only been tested in laboratory cell cultures—not in actual humans.
Accordingly, CB1R activation has been suggested as a target for anxiolytic drug development [15, 43, 44]. Proposed agents for enhancing CB1R activation include THC, which is a potent and direct agonist; synthetic CB1R agonists; FAAH inhibitors and other agents that increase eCB availability, as well as nonpsychoactive cannabis phytocannabinoids, including CBD. While CBD has low affinity for the CB1R, it functions as an indirect agonist, potentially via augmentation of CB1R constitutional activity, or via increasing AEA through FAAH inhibition (reviewed in [21]).
1.)  A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD conducted by Department of Psychiatry & Behavioral Sciences, Duke University Medical Center: The results are as followed… “Twenty-five (25%) percent of individual posts indicated that cannabis is therapeutic for ADHD, as opposed to 8% that it is harmful, 5% that it is both therapeutic and harmful, and 2% that it has no effect on ADHD.”  This was the first type of study done of its kind.  View Source

CBD oil refers to a natural botanical concentrate that is derived from the seeds and stalks of cannabis plants. This oil has a high concentration of cannabidiol, also known as CBD. Out of the identified cannabinoids in the cannabis plant, cannabidiol is the second most common after THC or tetrahydrocannabinol. However, unlike THC, cannabidiol is non-psychotropic. That means it’s use does not cause the euphoric high effect like traditional marijuana and THC products do.
Nora Volkow from the National Institute on Drug Abuse reiterated the decision of (then) two dozen states to allow medical marijuana to be used in one way or another in their jurisdictions. This should open everyone’s eyes to the sanctioning of a non-addictive, non-psychoactive substance which has been linked to benefits for patients suffering from seizure disorders, quite a few neurodegenerative disorders or pain resulting from cancer.

If you have fibromyalgia, then you’ve probably heard of the rave reviews people post online about CBD’s effect on it. For those of you who don’t know, fibromyalgia is a type of chronic disorder that causes widespread muscle pain, pain in the bones, and general fatigue. Since the measure of pain is subjective, it cannot be recorded or measured by tests.

Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. We at Plus CBD Oil™ are proud of our innovative selection of products.


But from joint pain to irritable bowel syndrome to diabetic retinopathy, CBD has been shown to modulate both acute and chronic inflammatory issues via several different mechanisms, and from the research I’ve seen and cited below, it’s even more powerful than many of the commonly recommend natural remedies for inflammation, such as curcumin, fish oil, resveratrol, anti-oxidants, proteolytic enzymes, Vitamin C, etc.
Various strains of "medical marijuana" are found to have a significant variation in the ratios of CBD-to-THC, and are known to contain other non-psychotropic cannabinoids.[60] Any psychoactive marijuana, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. Non-psychoactive hemp (also commonly-termed industrial hemp), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆-9 tetrahydrocannabinol concentration of no more than three-tenths of one percent (0.3%) on a dry weight basis.[61] Certain standards are required for legal growing, cultivating and producing the hemp plant. The Colorado Industrial Hemp Program registers growers of industrial hemp and samples crops to verify that the THC concentration does not exceed 0.3% on a dry weight basis.[61]
Evidence from human studies strongly supports the potential for CBD as a treatment for anxiety disorders: at oral doses ranging from 300 to 600 mg, CBD reduces experimentally induced anxiety in healthy controls, without affecting baseline anxiety levels, and reduces anxiety in patients with SAD. Limited results in healthy subjects also support the efficacy of CBD in acutely enhancing fear extinction, suggesting potential for the treatment of PTSD, or for enhancing cognitive behavioral therapy. Neuroimaging findings provide evidence of neurobiological targets that may underlie CBD’s anxiolytic effects, including reduced amygdala activation and altered medial prefrontal amygdala connectivity, although current findings are limited by small sample sizes, and a lack of independent replication. Further studies are also required to establish whether chronic, in addition to acute CBD dosing is anxiolytic in human. Also, clinical findings are currently limited to SAD, whereas preclinical evidence suggests CBD’s potential to treat multiple symptom domains relevant to GAD, PD, and, particularly, PTSD.
Well, apart from day to day anxiety that most of us suffer with, anxiety is actually a very complex disorder, which can be at times extremely paralyzing and debilitating. According to recent data published by the National Institute of Mental Health, Anxiety disorders affect 19.1% of adults in the United States in any given year. Furthermore, it is estimate that 31.1% of American adults experience any anxiety disorder at some time in their lives.

CBD behaves as a non-toxic compound and studies show that doses of 700 milligrams per day for 6 weeks did not show any overt toxicity in humans, suggesting that it can be used for prolonged treatment. Not only does the research show that CBD benefits including being effective in fighting breast cancer cells, data also suggests that it can be used to inhibit the invasion of lung and colon cancer, plus it possesses anti-tumor properties in gliomas and has been used to treat leukemia. (12)

More recently, 17 states have approved the use of low THC, high CBD products for medical reasons in limited situations. Each state has specific requirements and conditions that need to be followed in order to use CBD legally, such as patient registry requirements and definitions of products that are allowed. (23) The 17 states that allow limited access to marijuana products low in THC and high in CBD include:
Research shows that CBD benefits include producing antipsychotic effects. It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs as seen in using behavioral and neurochemical techniques in animal studies. Additionally, studies show that CBD prevents human experimental psychosis and is effective in open case reports and clinical trials in patients with schizophrenia, with a remarkable safety profile. (6)
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.

All this talk about THC lands us nicely in the whole “Full Spectrum vs. Pure Isolate” debate. Once you begin shopping for CBD products, you’ll notice a lot of jargon that gets thrown around without much explanation. Now that we’ve introduced THC into the conversation, we can talk about the difference between, and relative benefits of, Full Spectrum CBD and CBD Isolate (and the lesser-known contender: Broad Spectrum).

What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.


CBD is a naturally occurring substance, and it has recently experienced a surge in popularity among the wellness community after becoming more widely available on the high street. It is not legal for companies who produce CBD oil to make specific claims about exactly what health benefits the product can have, but scientific research into CBD has indicated it's got the potential to improve mental health issues including depression and anxiety, as well as providing relief from pain and other illnesses.
At first, some people who deal with anxiety are apprehensive about CBD oil because it comes from essentially the same plant as marijuana. Marijuana contains THC, which is the psychoactive compound that causes you to get ‘high’ during use, and can lead to increased anxiety or paranoia. CBD oil is nothing like marijuana, and it does not contain THC at all. CBD oil can actually treat some of the adverse effects of THC.
1.)  A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD conducted by Department of Psychiatry & Behavioral Sciences, Duke University Medical Center: The results are as followed… “Twenty-five (25%) percent of individual posts indicated that cannabis is therapeutic for ADHD, as opposed to 8% that it is harmful, 5% that it is both therapeutic and harmful, and 2% that it has no effect on ADHD.”  This was the first type of study done of its kind.  View Source
Evidence from human studies strongly supports the potential for CBD as a treatment for anxiety disorders: at oral doses ranging from 300 to 600 mg, CBD reduces experimentally induced anxiety in healthy controls, without affecting baseline anxiety levels, and reduces anxiety in patients with SAD. Limited results in healthy subjects also support the efficacy of CBD in acutely enhancing fear extinction, suggesting potential for the treatment of PTSD, or for enhancing cognitive behavioral therapy. Neuroimaging findings provide evidence of neurobiological targets that may underlie CBD’s anxiolytic effects, including reduced amygdala activation and altered medial prefrontal amygdala connectivity, although current findings are limited by small sample sizes, and a lack of independent replication. Further studies are also required to establish whether chronic, in addition to acute CBD dosing is anxiolytic in human. Also, clinical findings are currently limited to SAD, whereas preclinical evidence suggests CBD’s potential to treat multiple symptom domains relevant to GAD, PD, and, particularly, PTSD.

When we sleep, our brain rests and it grows new pathways. When we suffer from insomnia, we are unable to sleep properly, so the brain doesn’t get this benefit. That’s why hemp oil help anxiety is more than just helpful and it acts on several levels. First, you will notice that your sleep is improved. Then you will notice that you sleep longer and much better than usual.


Hi Cynthia, we use a Full Plant, Full Spectrum plant based CBD. We absolutely do NOT use an isolate or a synthetic. We add the herbs to create an enhanced experienced beyond that of just CBD. We believe that CBD is part of the solution, and when mixed with other herbs, we can create an experience that goes beyond CBD alone. Nature CBD is a proprietary blend made with unique herbs to create what we think is the perfect experience for our customers.

CBD Oil, derived from agricultural hemp, has been widely recognized for its many benefits on human health. It has grown in popularity amongst the medical community as a key supplement for maintaining homeostasis. Because CBD oil has the ability to talk to nearly every organ system in the body via the Endocannabinoid System (ECS) this plant-based nutrient plays a key role in optimizing balance and enhancing quality of life.

"Right now, any claims and dosing recommendations by any company making a CBD product for the medical marijuana market is purely anecdotal," he says. "Asking 100 people who use your product whether they feel better isn't real science. The products on the market are also different from what was used in the scientific studies that they are basing their claims upon. If a study found an anti-anxiety effect when dosing humans with synthetic CBD, that doesn't mean that your CBD oil that contains 18 percent CBD is going to reduce anxiety. It might even have the opposite effect."


Of all the reasons that people use CBD today, pain is the most common. The same can be said of cannabis in general. In the United States, over seventy million people suffer from chronic pain, which is defined as experiencing over one hundred days per year of pain. Physicians differentiate between neuropathic (usually chronic) and nociceptive pains (usually time-limited), and cannabis works on most neuropathic and many nociceptive types of pain. A number of studies have demonstrated that the endocannabinoid system is both centrally and peripherally involved in the processing of pain signals.[383] Most discussions of using CBD for pain treatment suggest that finding the right dosage is critical.


A research conducted by Ethan B Russo, GW Pharmaceuticals, WA, USA, suggests that CBD oil interacts with the protein cells in the body and sends chemical signals to your brain and immune system through a number of stimuli. This helps the cells positively respond to chronic pain. This oil is regularly suggested for people with inflammation and back pain because of its painkilling quality.
In a double-blind, placebo-controlled study, 24 smokers were randomly chosen to receive either an inhaler of CBD oil or a placebo. Participants were asked to take a puff every time they had an urge to puff a cigarette. Over the week, those with placebo inhalers saw no change in their total number of cigarettes consumed, while those who were taking CBD saw a nearly 40 percent drop in their intake. Using the inhaler decreased the number of cigarettes without increasing their craving for nicotine, pointing towards a purpose for Cannabidiol in the withdrawal process.
At Charlotte's Web, we stand behind our products 100%. We work hard to ensure that our quality is second to none, and thousands of our customers agree that this difference is something you will experience. We’re so convinced our products will make a difference you can actually feel, that if any product doesn’t meet your expectations, we want you to send it back within the first 30 days of delivery and we will happily give you the opportunity to exchange for another product or receive a full refund.
THC is a psychoactive substance, meaning it's the very thing that changes the chemistry in your brain to make you high when inhaling/consuming cannabis. That's why hemp is used to create CBD oil instead of cannabis, because it won't have the side effects of getting high (which, when being taken for medical purposes, is advisable to avoid due to risk of addiction).
Cannabinoids are neuroprotective, meaning that they help maintain and regulate brain health. The effects appear to be related to several actions they have on the brain, including the removal of damaged cells and the improved efficiency of mitochondria.[190] CBD and other antioxidant compounds in cannabis also work to reduce glutamate toxicity. Extra glutamate, which stimulates nerve cells in the brain to fire, causes cells to become over-stimulated, ultimately leading to cell damage or death. Thus, cannabinoids help protect brain cells from damage, keeping the organ healthy and functioning properly. CBD has also been shown to have an anti-inflammatory effect on the brain.[191]
Cannabidiol Oil, or CBD as it’s more commonly known, has recently moved to the forefront in the medical cannabis diaspora. It’s a rising star, boasting wide-ranging health benefits.Cannabidiol CBD is one of at least 85 known cannabinoids. These are compounds found in the cannabis plant. Unlike its infamous cousin THC (Tetrahydrocannabinol), however, CBD has no psychoactive properties whatsoever.
2.)  What a fantastic study with such positive results!  In a nation (United States) where 1 out of 3 people suffer from diabetes, WE NEED MORE STUDIES!  This was an animal study, but great results for CBD hemp oil to be a potential health benefit for humans.  Here’s what the study stated, “We now report that CBD potentially relievement significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-potentially relieveed control mice to an incidence of 30% in CBD-potentially relieveed mice.”  View Source
When pain is localized, topical products can be applied. These can be made using CBD-dominant cannabis as well as THC strains. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive. These may be available as CBD oils, ointments, salves, or other forms, and with varying ratios of CBD and THC (a ratio of 1:1 is often recommended as ideal for skin application). The skin has the highest amount and concentration of CB2 receptors in the body.

Your endocrine system consists of glands throughout your body which regulate everything from energy levels to metabolism to sex drive. One major function of this system is to produce excitation in response to stress, which is of course necessary for survival, but when it gets out of hand it can be a source of excess stress. One big effect of cannabidiol in the endocrine system seems to be to protect against excess stress by reducing susceptibility to stress-induced activation in the hypothalamus-pituitary-adrenal axis. CBD significantly decreases plasma cortisol levels, and this is actually why I started using CBD in the first place – to reduce my cortisol.


In September 2018, following its approval by the FDA for rare types of childhood epilepsy,[13] Epidiolex was rescheduled (by the Drug Enforcement Administration) as a Schedule V drug to allow for its prescription use.[14] This change applies only to FDA-approved products containing no more than 0.1 percent THC.[14] This allows GW Pharmaceuticals to sell Epidiolex, but it does not apply broadly and all other CBD-containing products remain Schedule I drugs.[14] Epidiolex still requires rescheduling in some states before it can be prescribed in those states.[65][66]
I have had RA for 21 yrs. This is the only product that I actually see, with my own eyes daily, my arthritic nodules shrinking big time. OMGosh, within 18 hours of taking the tendon nodules on my right wrist were GONE! o more need for wrist braces I have needed for years. I have friends that are experiencing great results to for fibromyalsia and chronic back pain!

In studying over 4,600 test subjects, researchers found that current cannabis users had fasting insulin levels that were up to 16 percent lower than their non-using counterparts, higher levels of HDL cholesterol that protects against diabetes, and 17 percent lower levels of insulin resistance. Respondents who had used cannabis in their lifetime but were not current users showed similar but less pronounced associations, indicating that the protective effect of cannabis fades with time.[180]
This is because hemp actually contains a whole host of other valuable properties - so it becomes a bit of a 'buy one, get a ton of other stuff free' type situation. In Celtic Wind Crops' CBD oil, powder and capsules, users will benefit from an intake of amino acids, omegas, flavonoids, vitamins, minerals and more along with the desired CBD. Essentially, it could be all your food supplements rolled into one.
Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
I’m considering this for my dog, a 50 pound border collie. She has muscle weakness in her back legs likely due to an injury several years ago and now those legs are also spasming at times when she walks. The vet put her on rimadyl (an anti-inflammatory nsaid specifically for dogs) and symptoms improved for several months but are now regressing. We’re guessing inflammation is at the root of it. She’s 13 and we’re willing to take on the risks of CBD although they seem to be low to none but wondering if there would be different considerations for her weight and species. Maybe a half capsule at morning and again at night? Or should we start with a whole one? Thank you!
2.)   Another great conclusion concerning the benefits of CBD hemp oil and Alzheimer’s, “In conclusion, we have found that prepotentially relievement with CBD prevented the expression of proteins potentially involved in tau phosphorylation and Aβ production in GMSCs. Therefore, we suggested that GMSCs preconditioned with CBD possess a molecular profile that might be more beneficial for the potentially relievement of AD.”
Just wanted to share with you that I have been ordering oil for my sister-in-law who had a Glioblastoma Multiform Brain Tumour. After surgery, 6 weeks of radiotherapy and 3 months of chemo (plus your amazing M10P treatments), my sister-in-law is tumour free as of today! Thank you so much for the service you provide. Feel free to share this story with other members who need a boost and some good news! Thanks again
Anyways, now we’re about to get to the good stuff, specifically things that I figured health-minded readers like you would actually find helpful, such as hormone balancing, de-stressing, enhanced sleep, fat loss, etc. But if you want to simply stop reading now, and take a side-track to go peruse the more than 20,000 articles published in peer reviewed journals that show the medical efficacy of CBD for a variety of other conditions in addition to what I’ve listed here, then knock yourself out.
Many people are tempted to believe that products that contain CBD only are the best, thinking that using just CBD alone is a more effective treatment. While products that contain single-molecule CBD, meaning that you won’t find any other compounds, are already provided as medicines, they are not exactly more efficient than whole plant extract CBD oil, when it comes to therapeutic effects.

Only recently, marijuana and chemically-related compounds have come back to being considered of therapeutic value. A prominent compound found in marijuana or cannabis, CBD, or cannabidiol, has been shown to treat numerous diseases. Researchers believe that in view of the very low toxicity and the generally benign side effects of CBD, neglecting or denying CBD benefits and its clinical potential is simply unacceptable.


To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases. But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
I'd recommend a full spectrum as you're getting all of the beneficial compounds from the plant, and they can work synergistically to enhance benefits. Isolate is only CBD, all the other compounds have been stripped away or filtered. Broad Spectrum still contains many of the beneficial effects of Full Spectrum but it still has some compounds (namely THC) stripped from it. You can find a lot of great info at ProjectCBD.org as well.

Scientific studies support ashwagandha’s ability not only to relieve stress, but also to protect brain cells against the deleterious effects of our modern lifestyles. For example, in validated models of anxiety and depression, ashwagandha has been demonstrated to be as effective as some tranquilizers and antidepressant drugs. Specifically, oral administration of ashwagandha for five days showed anxiety-relieving effects similar to those achieved by the anti-anxiety drug lorazepam (Ativan®), and antidepressant effects similar to those of the prescription antidepressant drug imipramine (Tofranil®).
Spanish scientists via their animal studies found that CBD improves the transmission of 5-HT1A, which is a sub-type of receptor of serotonin hormone. It is known that medicines which target the body’s serotonin system can help treat some cases of depression and dealing with anxiety. This is the reason why pharmaceuticals companies have made SSRIs or selective serotonin reuptake inhibitors such as Zoloft and Prozac. 
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