Multiple sclerosis (MS). A prescription-only nasal spray product (Sativex, GW Pharmaceuticals) containing both 9-delta-tetrahydrocannabinol (THC) and cannabidiol has been shown to be effective for improving pain, muscle-tightness, and urination frequency in people with MS. This product is used in over 25 countries outside of the United States. But there is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis when it is used alone. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness, but not muscle spasms, tiredness, bladder control, mobility, or well-being and quality of life in patients with MS.
While CBD is most commonly used to treat physiological symptoms, there’s a growing body of research that indicates it can also be used in the therapy of a range of mental health conditions, including anxiety. A study by the University of São Paulo found that CBD significantly reduces subjective anxiety, leading investigators to conclude that “These results suggest that CBD reduces anxiety in [social anxiety disorder] and that this is related to its effects on activity in limbic and paralimbic brain areas.”
For hemp-based CBD products, most folks have no problems with them getting into Canada. Canada that has specifically stated that they consider CBD whether it comes from hemp or medical marijuana to be a Scheduled II Drug, Class Scheduled II Drug, which means that it has reported medicinal benefits but they would like to control the regulation and the selling of those products. But I don't think they're regulating it too strictly.

The body of research on cannabidiol, CBD oil benefits, THC, and other cannabinoids has grown exponentially in the past decade. The following brings together the latest scientific studies and stories from patients and doctors with advice on treating specific symptoms. It also includes dosage suggestions and information on recommended types of cannabinoid-based medicines for the particular condition.
No, pure CBD oil does not contain THC, and therefore would not affect a drug test testing for THC. Most widely-used drug tests are comprised of an immunoassay that has antibodies for detecting metabolites that are produced from the oxidation of THC. These drug tests do not have cross-reactivity to CBD. Therefore, they give negative results when only pure CBD is used. One study of CBD oil users revealed that unlike THC, CBD does not show up on drug tests (source.)
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[25][26] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[27] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[28]
Individuals are continuously suffering varying degrees of anxiety about death. We did a study on “An overview of Death Anxiety”, https://goo.gl/PvKvMJ. Method of concept analyses and an extensive online literature have been used for this study. Overall data provided evidence that anxiety about death is rife within western culture. Its prevalence, particularly with women and significant number of cases elderly people experience less death anxiety than young people.
So am I to assume, due to no response/deleted comment that my simple question was too difficult to answer? With all the technical & correct information you have on you GREAT website, can someone (?) not simply correct or acknowledge the FACT the your NOT using nano-particle size product? I am truly interesting (for my wife) in CBD, have done my research, and I love working with numbers which is why if found this discrepancy. Comments welcome, but avoidance is disturbing.
I tried the CBD oil that comes from hemp cause that’s all that’s legal where I live and was really hoping it would help with my back pain but it does absolutely nothing. Might as well have bought a bottle of vegetable oil & saved $150. I think it’s the THC that’s in medical marijuana that offers true pain relief, looking forward to it being legal across the country not just in 30 states.
Despite the political and social controversy affiliated with it, the medical community must come to the realization that cannabinoids exist as a ubiquitous signaling system in many organ systems. Our understanding of cannabinoids and how they relate not only to homeostasis but also in disease states must be furthered through research, both clinically and in the laboratory.[174]

In general, indica varieties of THC appear to work best as a sleep aid for most people. However, a significant number of people find THC, even indica strains, will make the mind more active. For these people, CBD oil can benefit them and tends to work well, providing the relaxation and calm for the mental as well as the physical body. For these people, CBD taken at nighttime as part of a bedtime regime produces a restful sleep, not the alertness produced in the daytime. This bidirectional effect of CBD is the result of balancing the endocannabinoid system.
Cannabidiol (CBD) has NOT been proven to potentially relieve, relieve, nor cure any severe condition or medical condition listed on this site.  The medical studies, controlled tests, and health information offered on Cannabidiol Life of CBDOilsAndEdibles.com (or any variation of the URL) is an expressed summarization of our personal conducted research done by our team of professionals. The information provided on this site is designed to support, NEVER replace, the relationship that exists between a patient/site visitor and the patient's/site visitor's physician. Our products are not for use by or sale to persons under the age of 18. Our products should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are the property of their respective owners and are not affiliated with nor do they endorse this product.  These statements have not been evaluated by the FDA and products listed are not intended to diagnose, potentially relieve, cure or prevent any severe condition. Individual weight loss results will vary. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law.
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The immediate and powerful effects of THC are explained because of the special affinity it has with the CB1 type receptors, which mediate crucial processes in the brain. The less prominent (but no less important) action of CBD was explained, at least for a while, by hypothesizing that it binds to CB2 type receptors, hence its more diffuse manner of exercising changes in the body. Early on, the antipsychotic effects of cannabidiol were observed, an aspect which seemed to be in consonance with this initial hypothesis.
I have tried NatureCBD and believe in the product. I particularly noticed alleviation in joint pain and reduction in stress – although stress reduction may have been supported by pain reduction. However, since I live in Canada and it is expensive to ship, I have been using CBD from a licensed medical marijuana facility. The effect is not as powerful as from NatureCBD. I had not really considered the bioavailability issue; perhaps that is the reason for the weaker effect. Or possibly it could be the other herbs added, or the synergistic effect. In any case, I am going to bite the bullet (at least my visa card will) and go back to NatureCBD.
What do you think about CBD? Why offer those alternatives (which are good for everything, it is patently true not just “provable”, while it is probable). I have chronic pain and scoliosis as well as stiffness and fatigue from schizophrenia medication, and CBD is both antipsychotic and minimizes anxiety, as well as assists pain which allows me TO meditate or exercise. I can’t even do those half as effectively without medical marijuana products. Whatever they are proven to do, pot and pot components are thankfully getting proven and studied more rigorously and informatively.
CBD behaves as a non-toxic compound and studies show that doses of 700 milligrams per day for 6 weeks did not show any overt toxicity in humans, suggesting that it can be used for prolonged treatment. Not only does the research show that CBD benefits including being effective in fighting breast cancer cells, data also suggests that it can be used to inhibit the invasion of lung and colon cancer, plus it possesses anti-tumor properties in gliomas and has been used to treat leukemia. (12)

I have been sick with type 2 diebetic problems since 1997 and I just started to use cbd oil in a vape pen in 2018 I found that it really works well for controlling severe foot nerve pain and I can stop with the symbalta for nerve pain that has very bad side effects on me I also have hart problems with 2 stents put in I don’t know yet what will happen with the hart issues but waiting to see I do know I have been a calmer person not as aggressive like I used to be with less stress and pain and hyper aggressive violent attitude has went way down which was one of the symbalta side affects since I’m not depressed which what symbalta was made for but works also for nerve pain for diebetics but for me has reversed affects and makes me depressed and bad tude so all in all I’m sticking with the cbd oil I don’t know about future affects from use but like everything else theres al ways some kind of affect but I’m thinking this way is still better than hands full of pills every day that damage your liver and kidneys I’m not saying to stop your meds just the few that become not needed and replaced by the oil still have to take my shots to control sugar maybe one day big pharma will let the cure out but I will not hold my breath on that one haha so far so good have to see what the future brings take care all and do your research john
Best known for their role in beer brewing, the female flowers of hop are being increasingly used in supplements for insomnia, anxiety, and menopausal symptoms. In addition, research on their components has revealed new activities with promising clinical applications. Read below to learn more about hops’ components, health benefits, side effects, and interactions with drugs […]
– CBD Oil with THC; This kind of oil isn’t legitimate in all states and has an unexpected impact in comparison to unadulterated CBD oil. Numerous individuals take marijuana for THC, which aids them to fight distinctive restorative conditions. They trust that when the two are joined, they give a better experience that surpasses each other’s useful properties. Note that THC can counter the advantages of CBD and in this way, perfect dosing is fundamental.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
Very interesting article. I have terrible anxiety and nausea and I have been working with a Functional Medicine Practitioner for my gut issues, plus I have Hashimoto’s, under active thyroid, post menopause and also a mycotoxin issue. I wake up with anxiety and nausea every day, some days not quite so bad as others. I have absolutely no idea what is driving my anxiety. I am on SSRI’s and have been for years but they arn’t working that well anymore but I am on Seroxat so not looking to wean off because it’s the worst one on the market.
I am not a doctor and this is not to be taken, interpreted or construed as medical advice. Please talk with a licensed medical professional about this. These are just my own personal thoughts and not a prescription or a diagnosis or any form of health care whatsoever. HOWEVER, dosages of over 100mg have never been shown to be an issue, and I personally do 30-60mg per day (if you use the NatureCBD form you can take less because it's far more absorbable).
Your body is composed of over 60% water, and this means that you’re going to either A) need to take way, way more of a non water-soluble CBD product if you actually want to feel the effects or B) smoke or vape your CBD, which is logistically annoying and not something your kid or your pet can do (and yes, both kids and pets can enormously benefit from CBD usage).
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In summary: smaller doses of CBD provide you with a calm and relaxed focus that comes in handy during everything from writing to music to parties to workouts – very similar to what you would experience with THC, but without the psychoactive or paranoia properties. And if you combine these smaller doses of CBD with common natural sleep-inducing compounds like melatonin, magnesium, or lemon balm, then you can get yourself into an even more relaxed state. But larger doses of CBD (which are going to range based on the actual absorption of whichever CBD blend you are using) can be used all by themselves to enhance sleep or combat insomnia.

Many of the folks I coach and do consults with have always struggled with a “sensitive gut”, irritable bowel syndrome, bloating, gas, constipation and other signs of gut inflammation, and being able to use CBD to reduce gut inflammation could be a game-changer for these people. But from the joints to neural tissue, CBD has a variety of other natural anti-inflammatory effects. Here is just a smattering of the studies done on cannabidiols and inflammation.
Low Blood Pressure and Lightheadedness – an effect of CBD that may seem somewhat counterintuitive, an almost immediate (though small) decrease in blood pressure has been reported at the exposure to high doses, causing the associated lightheadedness, albeit not for long periods. Nevertheless, it could be significant for individuals taking blood pressure medication.
Supercritical CO2 extraction. Subcritical/Supercritical CO2 oil extraction has several advantages over other extraction mediums, such as alcohol and hydrocarbons: CO2 is nontoxic and is Generally Regarded As Safe (GRAS) by the FDA for use in food products. Our bodies produce it when we breathe, and it is commonly used in carbonated beverages. With CO2 as a solvent for oil extraction, no toxins, heavy metals or hydrocarbon materials come in contact with the extracted oils. CO2 is “solvent free”. Other extraction solvents, such as hydrocarbon based propellants like propane and butane, hexane and pentane, or ethanol/alcohol mixtures require additional distillation or purging beyond the extraction process to separate the solvent from the extracted oil. CO2 has a very low boiling temperature and wants to be a gas a room temperature, thus it naturally separates from the extracted oil the same way a soda goes “flat”. The spent plant material is also free of residual solvents so it can be re-used as well. CO2 is non-flammable. Flammable solvents must be processed in a NEMA Class 1, Division 1, 2 or 3 (explosion proof) environment. CO2 is not flammable and does not require costly explosion proof facilities. CO2 is “cold” – Botanical oil extractions can be done at temperatures that are native to the botanical material, minimizing thermal degradation of the plant material and the extracted oil. CO2 is “tunable” – the solvency power of CO2 can be adjusted simply by increasing or decreasing pressures and/or temperatures. The ability of the CO2 to selectively extract affords the ability to create unique extractions that have varying levels of desirable oils and waxes (see below). Less desirable plant constituents, like chlorophyl, can also be “de-selected”. CO2 is inexpensive. CO2 is readily available and widely used throughout several industries. In addition, Apeks’ production CO2 oil extraction systems recirculate and subsequently recover 95% of the CO2 used in each extraction. CO2 is environmentally friendly. Industrial CO2 for extractions comes from byproducts – primarily hydrogen and ammonia manufacturing and fermentation for ethanol. CO2 used for extractions does not contribute to the overall atmospheric CO2 levels.
In addition to fighting inflammation in the body, CBD oil may reduce anxiety by directly affecting the brain. Studies have found that CBD actually lowers activity in the amygdala and increases prefrontal cortex activation, two parts of the brain involved in anxiety. There is also evidence that CBD is able to activate hippocampus neurogenesis, aka regenerate new neurons! This activates CB1 receptors, which has a positive balancing impact on GABA and glutamate levels, associated with reducing anxiety.
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When pain is localized, topical products can be applied. These can be made using CBD-dominant cannabis as well as THC strains. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive. These may be available as CBD oils, ointments, salves, or other forms, and with varying ratios of CBD and THC (a ratio of 1:1 is often recommended as ideal for skin application). The skin has the highest amount and concentration of CB2 receptors in the body.
CBD inhibited escape responses in the ETM and increased DPAG escape electrical threshold [68], both proposed models of panic attacks [95]. These effects partially depended on 5-HT1AR activation but were not affected by CB1R blockade. CBD was also panicolytic in the predator–prey model, which assesses explosive escape and defensive immobility in response to a boa constrictor snake, also partially via 5-HT1AR activation; however, more consistent with an anxiogenic effect, CBD was also noted to decrease time spent outside the burrow and increase defensive attention (not shown in Table ​Table1)1) [75, 86] . Finally, CBD, partially via CB1Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [89]. Anticompulsive effects of CBD were investigated in marble-burying behavior, conceptualized to model OCD [96]. Acute systemic CBD reduced marble-burying behavior for up to 7 days, with no attenuation in effect up to high (120 mg/kg) doses, and effect shown to depend on CB1Rs but not 5-HT1ARs [71, 74, 88].
My dad has severe advanced stage Dementia. Will CBD oil help him at this point? He is now refusing to eat any solid food, but will accept most drinks.In addition, he has lost a great deal of weight even though they're giving him Mega Shakes containing a full meals worth of proteins, etc. He gets at least 4 of these a day..some which he refuses. Is his Dementia too far gone for CBD oils to help him?
Our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia. In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism. (Source)
Always start with the micro dose to test sensitivity and go up as needed within the dosing range, before going to the next, until symptoms subside. The micro to standard dose is usually recommended to treat stress and anxiety with CBD. For relief of immediate symptoms, as in a panic or anxiety attack, vaporizing or smoking work well. The medication lasts one to three hours, whereas most ingested products, including CBD oil, take thirty to sixty minutes before taking effect and last six to eight hours. Vaporizers that use a cartridge filled with the CO2 concentrate are highly effective, and these are available in various ratios of CBD to THC. Herbal vaporizers that use the whole plant are also an effective delivery method. Sublingual sprays or tinctures taken as liquid drops take effect quickly and last longer than inhaled products.
A 2012 study published in the British Journal of Pharmacology found that CBD benefits including possessing anti-nausea and antiemetic effects when it was administered to rats. (13) Researchers found that CBD acts in a diphasic manner, meaning that in low doses it suppresses toxin-induced vomiting, but in high doses it increases nausea or has no effect.
Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports. Little research has focused on the safety and side effects of CBD in humans; however, clinical trials indicate that only a few, generally mild side effects have been observed after CBD administration and tolerance for CBD does not seem to occur.

1.)  In a study that was conducted in 2011, researchers compared the experiences of patients that used cannabis on regular basis with those of patients that didn’t use cannabis. The researchers established that there was a “statistically significant reduction of pain and stiffness, enhancement of relaxation, and increase in somnolence and feeling of well being”. View Source


According to the National Institute of Mental Health, approximately 15 million adults in the United States have social phobia and about 6.8 million have a generalized anxiety disorder. Traditional treatment usually involves counseling and medications. Treatment with CBD may be better than anti-depressants because it acts quickly and does not cause side effects or withdrawal symptoms.
CBD for insomnia is becoming a more popular choice as sufferers from sleeplessness struggle to find a cure. For many users of CBD, better sleep is a common benefit. This is due to CBD’s many positive influences on the central nervous system, including greater relaxation and mood. As CBD tends to calm anxiety and generally help with the ability to sleep soundly, this powerful, natural agent should be considered one of the best ways to sleep fully and restfully during the night.
It’s also nearly impossible to overdose on CBD. Kind of like water, dark chocolate, and steamed kale, it has an unusually low level of toxicity. In the last 6,000 years, CBD hasn’t killed anyone via overdose, which is particularly impressive when you compare it to non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, Advil and Tylenol, which can wreak havoc on your gut lining, liver and kidneys. Or aspirin (salicylic acid) which kills over 1,000 people every year. Or alcohol, which kills over 110,000 people a year. No one’s ever died from CBD.
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[25][26] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[27] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[28]
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”

Spanish scientists via their animal studies found that CBD improves the transmission of 5-HT1A, which is a sub-type of receptor of serotonin hormone. It is known that medicines which target the body’s serotonin system can help treat some cases of depression and dealing with anxiety. This is the reason why pharmaceuticals companies have made SSRIs or selective serotonin reuptake inhibitors such as Zoloft and Prozac.
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